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iGMDRD283

Canonical SMILES: CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC

InChI: InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

InChI Key: UBPYILGKFZZVDX-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Bosutinib	CHEMBL288441 CHEMBL2131134	5328940	DB06616	Alone	Small Molecule

Drug Class:

Amines Antineoplastic Agents Antineoplastic and Immunomodulating Agents Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Immunosuppressive Agents Kinase Inhibitor Myelosuppressive Agents P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Protein Kinase Inhibitors

Drug Targets:

BCR (P11274)ABL1 (P00519)LYN (P07948)HCK (P08631)SRC (P12931)CDK2 (P24941)MAP2K1 (Q02750)MAP2K2 (P36507)MAP3K2 (Q9Y2U5)CAMK2G (Q13555)TEC

Drug Pathways:

Other, kinases

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
7514	XPO1	1
4627	MYH9	1
2956	MSH6	1
3852	KRT5	1
103	ADAR	1
3845	KRAS	1
9757	KMT2B	2
84337	ELOF1	1
2033	EP300	1
7428	VHL	1
58508	KMT2C	1
7157	TP53	1
4436	MSH2	1
4089	SMAD4	1
1956	EGFR	2
7301	TYRO3	1
5728	PTEN	2
1869	E2F1	1
3429	IFI27	1
171023	ASXL1	2
29994	BAZ2B	1
100124696	TEC	1
5054	SERPINE1	1
25	ABL1	17

Gene in drug-gene network: Network Plot

Models in Bosutinib

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.