KMT2C
Summary: This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysine methyltransferase 2C | MIM:606833 | Ensembl:ENSG00000055609 | HGNC:HGNC:13726 | PA30847 | 7q36.1 |
GO terms in KMT2C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003713 | transcription coactivator activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016746 | transferase activity, transferring acyl groups |
| MF | TAS | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IBA | GO:0042393 | histone binding |
| MF | IBA | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| MF | IDA | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0035097 | histone methyltransferase complex |
| CC | IBA | GO:0044666 | MLL3/4 complex |
| CC | IDA | GO:0044666 | MLL3/4 complex |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051568 | histone H3-K4 methylation |
Gene expression in normal tissue: KMT2C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KMT2C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
| wikipathways | WP2369 | Histone Modifications |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD389 | SB525334 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD505 | Pevonedistat | 7 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD351 | GW843682X | 8 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 5 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 8 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 6 |
| iGMDRD552 | AZD-1775 | 5 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD583 | LDN 193189 | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD605 | AZD6482 | 1 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD260 | FQI-2 | 6 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD780 | PP-30 | 5 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD433 | Lexibulin | 6 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD670 | ML 210 | 4 |
| iGMDRD283 | Bosutinib | 1 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD466 | Chaetocin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KMT2C
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.