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iGMDRD405

Canonical SMILES: CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)N=CC2=CN=C3N2C=C(C=C3)Br

InChI: InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+

InChI Key: QTHCAAFKVUWAFI-DJKKODMXSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
PIK-75	10275800	Alone	Small Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	3
8999	CDKL2	6
8019	BRD3	2
5027	P2RX7	1
6491	STIL	3
11183	MAP4K5	6
4168	MCF2	2
150465	TTL	6
3708	ITPR1	2
10783	NEK6	3
1588	CYP19A1	2
1969	EPHA2	3
3845	KRAS	4
4750	NEK1	1
6351	CCL4	2
137994	LETM2	3
701	BUB1B	2
3939	LDHA	3
25778	DSTYK	3
4352	MPL	3
6597	SMARCA4	2
3551	IKBKB	1
5133	PDCD1	4
843	CASP10	3
3069	HDLBP	1
11116	FGFR1OP	3
6598	SMARCB1	3
3320	HSP90AA1	3
3066	HDAC2	1
23310	NCAPD3	2
57172	CAMK1G	6
6887	TAL2	3
2249	FGF4	2
51199	NIN	5
114783	LMTK3	4
26039	SS18L1	2
3727	JUND	3
5579	PRKCB	2
31	ACACA	5
1602	DACH1	4
51755	CDK12	5
9048	ARTN	1
5966	REL	3
29998	BICRA	3
8295	TRRAP	2
10438	C1D	2
51512	GTSE1	3
2033	EP300	2
9578	CDC42BPB	2
51776	MAP3K20	3
26353	HSPB8	3
80351	TNKS2	3
51343	FZR1	2
10188	TNK2	2
9636	ISG15	6
2908	NR3C1	2
51804	SIX4	2
5601	MAPK9	3
3688	ITGB1	2
6928	HNF1B	1
4194	MDM4	2
7088	TLE1	3
83931	STK40	2
23405	DICER1	1
1992	SERPINB1	1
6709	SPTAN1	3
158056	MAMDC4	1
5591	PRKDC	1
2778	GNAS	1
28996	HIPK2	2
575	ADGRB1	4
53942	CNTN5	1
2734	GLG1	3
9564	BCAR1	1
6792	CDKL5	2
1123	CHN1	2
5450	POU2AF1	3
91461	PKDCC	3
23152	CIC	3
5863	RGL2	2
10290	SPEG	2
9319	TRIP13	3
2201	FBN2	2
27436	EML4	2
58508	KMT2C	3
6092	ROBO2	2
57194	ATP10A	1
7869	SEMA3B	4
3791	KDR	6
2263	FGFR2	2
85481	PSKH2	5
4869	NPM1	2
863	CBFA2T3	2
1555	CYP2B6	3
5600	MAPK11	2
7038	TG	4
6197	RPS6KA3	3
65125	WNK1	2
4436	MSH2	1
676	BRDT	3
1656	DDX6	1
80205	CHD9	2
2000	ELF4	1
4026	LPP	4
4089	SMAD4	1
1616	DAXX	1
256536	TCERG1L	3
9252	RPS6KA5	3
9448	MAP4K4	1
546	ATRX	3
3417	IDH1	2
1978	EIF4EBP1	3
56997	COQ8A	1
3702	ITK	1
1198	CLK3	2
2931	GSK3A	4
4145	MATK	3
4293	MAP3K9	3
26524	LATS2	1
7043	TGFB3	3
10565	ARFGEF1	3
57154	SMURF1	3
675	BRCA2	2
1956	EGFR	1
5155	PDGFB	3
6776	STAT5A	2
27330	RPS6KA6	3
7189	TRAF6	3
3949	LDLR	2
6011	GRK1	1
3315	HSPB1	3
6095	RORA	5
29844	TFPT	5
5205	ATP8B1	2
7468	NSD2	3
9064	MAP3K6	1
7849	PAX8	3
9321	TRIP11	6
664	BNIP3	3
1230	CCR1	3
23396	PIP5K1C	4
8312	AXIN1	3
5595	MAPK3	2
1869	E2F1	3
115701	ALPK2	1
284086	NEK8	2
352909	DNAAF3	5
140803	TRPM6	1
6146	RPL22	2
890	CCNA2	3
2264	FGFR4	2
177	AGER	6
1676	DFFA	1
3899	AFF3	2
7465	WEE1	3
7454	WAS	3
85415	RHPN2	3
54904	NSD3	3
3161	HMMR	4
2046	EPHA8	2
8821	INPP4B	3
84930	MASTL	5
8805	TRIM24	2
2353	FOS	5
286151	FBXO43	2
57820	CCNB1IP1	1
57680	CHD8	1
2869	GRK5	2
100124696	TEC	3
5395	PMS2	2
171389	NLRP6	2
7094	TLN1	4
3181	HNRNPA2B1	1
1281	COL3A1	3
9201	DCLK1	3
63976	PRDM16	3
3557	IL1RN	3
6760	SS18	2
2194	FASN	2
5583	PRKCH	2
53335	BCL11A	3
3709	ITPR2	1
6778	STAT6	2
84254	CAMKK1	3
5932	RBBP8	3
3977	LIFR	2
4261	CIITA	2
84072	HORMAD1	2
170685	NUDT10	6
80781	COL18A1	1
2122	MECOM	3
51167	CYB5R4	3
5584	PRKCI	2
2065	ERBB3	2
862	RUNX1T1	1
112268437	LOC112268437	1
8841	HDAC3	3
4638	MYLK	2
7040	TGFB1	2
55959	SULF2	3
9878	TOX4	3
3488	IGFBP5	2
4915	NTRK2	3
55422	ZNF331	2
138474	TAF1L	2
4613	MYCN	3
1840	DTX1	3
440270	GOLGA8B	3
5288	PIK3C2G	5
2044	EPHA5	2
5287	PIK3C2B	1
1608	DGKG	1
7294	TXK	4
1499	CTNNB1	1
5602	MAPK10	2
167359	NIM1K	2
5970	RELA	3

Gene in drug-gene network: Network Plot

Models in PIK-75

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