ROBO2
Summary: The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| roundabout guidance receptor 2 | MIM:602431 | Ensembl:ENSG00000185008 | HGNC:HGNC:10250 | PA34621 | 3p12.3 |
Gene Categories:
CELL SURFACEGO terms in ROBO2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001656 | metanephros development |
| BP | IMP | GO:0001657 | ureteric bud development |
| BP | ISS | GO:0003148 | outflow tract septum morphogenesis |
| BP | ISS | GO:0003180 | aortic valve morphogenesis |
| BP | ISS | GO:0003184 | pulmonary valve morphogenesis |
| BP | ISS | GO:0003272 | endocardial cushion formation |
| BP | IDA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | ISS | GO:0007411 | axon guidance |
| BP | TAS | GO:0007411 | axon guidance |
| BP | NAS | GO:0007417 | central nervous system development |
| BP | IEP | GO:0007420 | brain development |
| BP | ISS | GO:0016199 | axon midline choice point recognition |
| BP | IEA | GO:0021510 | spinal cord development |
| BP | ISS | GO:0021891 | olfactory bulb interneuron development |
| BP | ISS | GO:0031290 | retinal ganglion cell axon guidance |
| BP | IEP | GO:0032870 | cellular response to hormone stimulus |
| BP | IEA | GO:0035385 | Roundabout signaling pathway |
| BP | ISS | GO:0035481 | positive regulation of Notch signaling pathway involved in heart induction |
| BP | ISS | GO:0035904 | aorta development |
| BP | IDA | GO:0050772 | positive regulation of axonogenesis |
| BP | IDA | GO:0050925 | negative regulation of negative chemotaxis |
| BP | ISS | GO:0051964 | negative regulation of synapse assembly |
| BP | ISS | GO:0060412 | ventricular septum morphogenesis |
| BP | IEP | GO:0061364 | apoptotic process involved in luteolysis |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0030673 | axolemma |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008046 | axon guidance receptor activity |
| MF | NAS | GO:0008046 | axon guidance receptor activity |
| MF | IDA | GO:0042802 | identical protein binding |
Gene expression in normal tissue: ROBO2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ROBO2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO |
| reactome | R-HSA-8985801 | Regulation of cortical dendrite branching |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-9010642 | ROBO receptors bind AKAP5 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD188 | Piperlongumine | 9 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD613 | CHEMBL258148 | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD47 | ZM336372 | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 6 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD410 | Ko-143 | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD552 | AZD-1775 | 4 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD322 | FK 866 | 4 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD289 | Parthenolide | 7 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD121 | GMX1778 | 9 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ROBO2
CLASSFICATION
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