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iGMDRD435

Canonical SMILES: CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C

InChI: InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1

InChI Key: XQVVPGYIWAGRNI-JOCHJYFZSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
BI-2536	CHEMBL513909	11364400	Alone	Small Molecule

Drug Targets:

PLK1 PLK2 PLK3

Drug Pathways:

Cell cycle

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
4854	NOTCH3	1
7514	XPO1	2
7837	PXDN	6
11183	MAP4K5	7
4627	MYH9	7
2956	MSH6	1
3757	KCNH2	6
6351	CCL4	4
84700	MYO18B	4
150209	AIFM3	2
81035	COLEC12	2
8780	RIOK3	6
10395	DLC1	3
4170	MCL1	2
10142	AKAP9	2
7080	NKX2-1	5
51199	NIN	3
577	ADGRB3	2
10454	TAB1	3
8844	KSR1	2
10178	TENM1	3
2625	GATA3	1
10438	C1D	5
5159	PDGFRB	1
7158	TP53BP1	1
83439	TCF7L1	3
84033	OBSCN	3
342667	STAC2	4
8852	AKAP4	2
2242	FES	3
2042	EPHA3	3
4792	NFKBIA	5
116986	AGAP2	4
3688	ITGB1	6
1992	SERPINB1	6
1277	COL1A1	3
85443	DCLK3	2
65266	WNK4	4
9020	MAP3K14	1
23387	SIK3	6
9759	HDAC4	4
8714	ABCC3	3
9472	AKAP6	2
80243	PREX2	5
139285	AMER1	2
7010	TEK	5
898	CCNE1	5
5327	PLAT	6
5834	PYGB	1
7157	TP53	1
6092	ROBO2	3
4857	NOVA1	4
8218	CLTCL1	3
5910	RAP1GDS1	6
3791	KDR	1
10114	HIPK3	4
84513	PLPP5	6
4086	SMAD1	1
1019	CDK4	1
84075	FSCB	3
55034	MOCOS	3
57591	MRTFA	3
7175	TPR	3
5871	MAP4K2	6
3643	INSR	3
4089	SMAD4	1
10733	PLK4	3
5290	PIK3CA	1
1000	CDH2	3
2318	FLNC	6
675	BRCA2	2
3308	HSPA4	6
26278	SACS	4
6446	SGK1	3
3553	IL1B	5
8900	CCNA1	4
93627	TBCK	3
7153	TOP2A	8
6095	RORA	2
84441	MAML2	3
1024	CDK8	3
8312	AXIN1	3
51592	TRIM33	2
23281	MTUS2	4
4004	LMO1	6
5305	PIP4K2A	3
2188	FANCF	3
2648	KAT2A	1
1950	EGF	3
6789	STK4	3
2119	ETV5	6
23332	CLASP1	6
7385	UQCRC2	1
4619	MYH1	3
2067	ERCC1	1
9223	MAGI1	1
10735	STAG2	1
54101	RIPK4	3
283455	KSR2	2
598	BCL2L1	1
5587	PRKD1	2
3717	JAK2	3
2157	F8	2
5506	PPP1R3A	3
8428	STK24	3
51562	MBIP	5
1515	CTSV	6
4893	NRAS	5
2065	ERBB3	1
2074	ERCC6	1
8661	EIF3A	3
3488	IGFBP5	1
2073	ERCC5	3
4593	MUSK	3
10048	RANBP9	6
55193	PBRM1	1
83732	RIOK1	3
56155	TEX14	3
2892	GRIA3	3
4916	NTRK3	6

Gene in drug-gene network: Network Plot

Models in BI-2536

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.