MAP3K14
Summary: This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 14 | MIM:604655 | Ensembl:ENSG00000006062 | HGNC:HGNC:6853 | PA30597 | 17q21.31 |
GO terms in MAP3K14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004704 | NF-kappaB-inducing kinase activity |
| MF | IEA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | ISS | GO:0006955 | immune response |
| BP | ISS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0038061 | NIK/NF-kappaB signaling |
| BP | IBA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0051607 | defense response to virus |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
Gene expression in normal tissue: MAP3K14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K14
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1434 | Osteopontin Signaling |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2112 | IL17 signaling pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP262 | EBV LMP1 signaling |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | nfkappabalternativepathway | Alternative NF-kappaB pathway |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_TNFalpha | TNFalpha |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | tnfr2pathway | tnfr2 signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5676590 | NIK-->noncanonical NF-kB signaling |
| reactome | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD103 | SN-38 | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD435 | BI-2536 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K14
CLASSFICATION
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