MAP3K14

Summary: This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase kinase kinase 14
OMIM IDMIM:604655
Ensembl IDEnsembl:ENSG00000006062
HGNC IDHGNC:HGNC:6853
PHARMGKB IDPA30597
Map Location17q21.31

GO terms in MAP3K14


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004672 protein kinase activity
MF EXP GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004674 protein serine/threonine kinase activity
MF ISS GO:0004704 NF-kappaB-inducing kinase activity
MF IEA GO:0004709 MAP kinase kinase kinase activity
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: MAP3K14

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 17LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6

Gene-drug pathway distribution

undefined9Cell cycle2Apoptosis regulation1Longevity regulating pathway1DNA replication1Purine metabolism1

Pathways in MAP3K14


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Database
Pathway ID
Pathway Des.
wikipathways WP1434 Osteopontin Signaling
wikipathways WP1544 MicroRNAs in cardiomyocyte hypertrophy
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP195 IL-1 signaling pathway
wikipathways WP2036 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathways WP2112 IL17 signaling pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD103 SN-38 1
iGMDRD1008 SR-II-138A 1
iGMDRD772 BRD4770 3
iGMDRD781 Sirolimus 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K14

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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