SEARCH

HOME / SEARCH / SN-38

iGMDRD103

Canonical SMILES: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O

InChI: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1

InChI Key: FJHBVJOVLFPMQE-QFIPXVFZSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
SN-38	CHEMBL837	104842	DB05482	Alone	Small Molecule

Drug Targets:

TOP1 (P11387)

Drug Pathways:

DNA replication Drug metabolism - other enzymes

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
1105	CHD1	2
27125	AFF4	3
4854	NOTCH3	5
7514	XPO1	1
10903	MTMR11	2
471	ATIC	3
1464	CSPG4	3
10641	NPRL2	3
8444	DYRK3	3
10987	COPS5	6
7750	ZMYM2	1
11183	MAP4K5	3
5546	PRCC	2
23513	SCRIB	2
2956	MSH6	1
57679	ALS2	3
3708	ITPR1	2
57554	LRRC7	2
1969	EPHA2	2
7272	TTK	6
3845	KRAS	3
51347	TAOK3	3
23097	CDK19	3
2335	FN1	1
5593	PRKG2	3
53616	ADAM22	1
83942	TSSK1B	3
4036	LRP2	2
11160	ERLIN2	6
353345	GPR141	2
5133	PDCD1	2
843	CASP10	3
3069	HDLBP	3
7942	TFEB	3
51684	SUFU	3
6598	SMARCB1	3
10142	AKAP9	1
7253	TSHR	2
23310	NCAPD3	6
1404	HAPLN1	2
22821	RASA3	6
9757	KMT2B	1
1545	CYP1B1	3
79934	COQ8B	4
28231	SLCO4A1	2
1387	CREBBP	6
8106	PABPN1	3
10454	TAB1	3
2043	EPHA4	2
3727	JUND	3
55023	PHIP	3
2313	FLI1	3
4881	NPR1	8
5579	PRKCB	2
31	ACACA	1
1602	DACH1	3
51755	CDK12	2
5966	REL	3
3604	TNFRSF9	2
8295	TRRAP	3
10438	C1D	5
11122	PTPRT	1
23617	TSSK2	2
6722	SRF	3
2033	EP300	6
6927	HNF1A	4
54567	DLL4	2
9578	CDC42BPB	4
83439	TCF7L1	3
3227	HOXC11	3
6390	SDHB	6
10818	FRS2	5
54477	PLEKHA5	3
57670	KIAA1549	5
22861	NLRP1	3
440279	UNC13C	5
4301	AFDN	4
84033	OBSCN	6
5607	MAP2K5	2
342977	NANOS3	3
152137	CCDC50	2
57787	MARK4	6
169436	STKLD1	3
1586	CYP17A1	3
6256	RXRA	3
1591	CYP24A1	3
9175	MAP3K13	3
8313	AXIN2	3
6091	ROBO1	2
2260	FGFR1	6
5330	PLCB2	4
23255	MTCL1	2
730249	ACOD1	1
80129	CCDC170	3
10188	TNK2	5
83990	BRIP1	6
5601	MAPK9	3
6928	HNF1B	1
2045	EPHA7	2
23405	DICER1	3
171019	ADAMTS19	3
375449	MAST4	3
22858	ICK	3
287015	TRIM42	2
8643	PTCH2	3
65217	PCDH15	2
3916	LAMP1	3
8395	PIP5K1B	3
9020	MAP3K14	1
29775	CARD10	3
23191	CYFIP1	3
440730	TRIM67	3
6416	MAP2K4	6
9759	HDAC4	2
7525	YES1	3
6709	SPTAN1	3
50488	MINK1	2
2068	ERCC2	5
5591	PRKDC	1
7166	TPH1	8
3667	IRS1	2
2580	GAK	3
1009	CDH11	3
139285	AMER1	6
575	ADGRB1	2
53942	CNTN5	3
2734	GLG1	3
6792	CDKL5	2
7010	TEK	2
5450	POU2AF1	4
898	CCNE1	1
2272	FHIT	8
2066	ERBB4	2
10290	SPEG	5
2201	FBN2	2
1029	CDKN2A	1
10062	NR1H3	2
9794	MAML1	3
83694	RPS6KL1	3
58508	KMT2C	6
7157	TP53	3
4088	SMAD3	3
27086	FOXP1	8
79058	ASPSCR1	2
57194	ATP10A	4
4857	NOVA1	3
25836	NIPBL	3
4292	MLH1	4
93210	PGAP3	6
114788	CSMD3	2
5585	PKN1	3
9639	ARHGEF10	6
7249	TSC2	3
1019	CDK4	3
7409	VAV1	3
11213	IRAK3	3
9967	THRAP3	3
55034	MOCOS	3
9088	PKMYT1	3
5077	PAX3	5
6197	RPS6KA3	3
136332	LRGUK	2
652	BMP4	3
57578	UNC79	2
4026	LPP	6
8997	KALRN	4
57551	TAOK1	3
2175	FANCA	2
23469	PHF3	6
4089	SMAD4	2
170692	ADAMTS18	3
6654	SOS1	3
7204	TRIO	6
23373	CRTC1	2
285220	EPHA6	4
5606	MAP2K3	3
2047	EPHB1	6
30827	CXXC1	3
340533	NEXMIF	2
3702	ITK	1
440275	EIF2AK4	5
3239	HOXD13	1
3720	JARID2	3
5034	P4HB	8
1000	CDH2	2
10565	ARFGEF1	6
57154	SMURF1	3
675	BRCA2	4
607	BCL9	1
7075	TIE1	2
744	MPPED2	5
1956	EGFR	4
640	BLK	4
3065	HDAC1	3
4609	MYC	3
4684	NCAM1	5
26278	SACS	2
283629	TSSK4	3
5462	POU5F1B	3
1440	CSF3	3
6776	STAT5A	2
6446	SGK1	3
5592	PRKG1	2
7917	BAG6	3
375056	MIA3	3
137872	ADHFE1	3
56924	PAK6	3
57082	KNL1	3
84630	TTBK1	5
1981	EIF4G1	2
1213	CLTC	3
22976	PAXIP1	2
3315	HSPB1	6
23532	PRAME	1
780	DDR1	3
83452	RAB33B	5
8986	RPS6KA4	3
867	CBL	3
29844	TFPT	2
5205	ATP8B1	4
8626	TP63	2
460	ASTN1	3
8178	ELL	3
9064	MAP3K6	3
7849	PAX8	6
9509	ADAMTS2	1
23396	PIP5K1C	5
8312	AXIN1	2
10752	CHL1	5
208	AKT2	3
51330	TNFRSF12A	6
5595	MAPK3	2
1869	E2F1	6
667	DST	5
23281	MTUS2	6
6770	STAR	3
2188	FANCF	3
2324	FLT4	2
4055	LTBR	2
7273	TTN	1
8522	GAS7	2
23332	CLASP1	3
7059	THBS3	2
85415	RHPN2	2
6787	NEK4	3
8667	EIF3H	6
29941	PKN3	3
79012	CAMKV	2
2046	EPHA8	4
23305	ACSL6	3
344905	ATP13A5	2
51151	SLC45A2	5
10076	PTPRU	2
57680	CHD8	5
5923	RASGRF1	3
2690	GHR	3
2317	FLNB	6
100124696	TEC	3
9659	PDE4DIP	6
131890	GRK7	3
3624	INHBA	3
2194	FASN	3
5927	KDM5A	3
5587	PRKD1	3
5589	PRKCSH	3
57448	BIRC6	4
8317	CDC7	3
3717	JAK2	3
7227	TRPS1	3
1627	DBN1	4
6778	STAT6	3
8428	STK24	2
182	JAG1	3
7046	TGFBR1	3
2122	MECOM	3
1760	DMPK	2
5087	PBX1	1
4974	OMG	4
5925	RB1	2
4217	MAP3K5	3
4893	NRAS	1
5324	PLAG1	3
10420	TESK2	2
7403	KDM6A	4
2534	FYN	3
4638	MYLK	6
9878	TOX4	3
4915	NTRK2	4
91607	SLFN11	1
11086	ADAM29	1
142	PARP1	2
2261	FGFR3	6
23072	HECW1	3
55422	ZNF331	3
57697	FANCM	2
63893	UBE2O	4
1840	DTX1	3
2044	EPHA5	2
5287	PIK3C2B	2
4629	MYH11	4
30811	HUNK	4
4193	MDM2	2
23112	TNRC6B	2
2178	FANCE	2
27255	CNTN6	4
1803	DPP4	1
1499	CTNNB1	4
2444	FRK	3
3440	IFNA2	3
2892	GRIA3	7
1436	CSF1R	3
1795	DOCK3	5
167359	NIM1K	3
11035	RIPK3	3
5970	RELA	2
1488	CTBP2	4

Gene in drug-gene network: Network Plot

Models in SN-38

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.