PCDH15


Summary: This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protocadherin related 15MIM:605514Ensembl:ENSG00000150275HGNC:HGNC:14674PA3299910q21.1

Gene Categories:

DRUGGABLE GENOME

GO terms in PCDH15


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005509calcium ion binding
BPIBAGO:0007155cell adhesion
BPIEAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIBAGO:0007267cell-cell signaling
BPIMPGO:0007605sensory perception of sound
BPIMPGO:0045494photoreceptor cell maintenance
BPIEAGO:0048839inner ear development
BPIMPGO:0050953sensory perception of light stimulus
BPIMPGO:0050957equilibrioception
CCIDAGO:0001750photoreceptor outer segment
CCIEAGO:0005576extracellular region
CCIBAGO:0005887integral component of plasma membrane
CCISSGO:0032420stereocilium
CCIDAGO:0045202synapse

Gene expression in normal tissue: PCDH15

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PCDH15


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 125
iGMDRD260FQI-21
iGMDRD52Rotenone1
iGMDRD399Selumetinib6
iGMDRD188Piperlongumine7
iGMDRD780PP-303
iGMDRD562Navitoclax5
iGMDRD64Parbendazole5
iGMDRD444Tivantinib1
iGMDRD23Gossypol7
iGMDRD151CHM-11
iGMDRD126Tipifarnib3
iGMDRD420Leucascandrolide A2
iGMDRD1008SR-II-138A3
iGMDRD772BRD47701
iGMDRD889Compound 7d-cis3
iGMDRD670ML 2107
iGMDRD546BMS-7548073
iGMDRD494Neopeltolide3
iGMDRD446LY 21832402
iGMDRD193Fqi14
iGMDRD679Bistramide A1
iGMDRD466Chaetocin5
iGMDRD297Austocystin D6
iGMDRD137Indisulam4
iGMDRD158NSC1415407
iGMDRD103SN-382
iGMDRD434BMS-5369243
iGMDRD705Nakiterpiosin6
iGMDRD289Parthenolide6
iGMDRD267Oligomycin A8
iGMDRD872BRD71376
iGMDRD286Nsc 63283910
iGMDRD871BRD63681
iGMDRD414MST-3123
iGMDRD366PI-1032
iGMDRD263AACOCF33
iGMDRD552AZD-17751
iGMDRD246NPC263
iGMDRD505Pevonedistat6
iGMDRD300Tozasertib3
iGMDRD307Manumycin A2
iGMDRD299ICL 6701
iGMDRD522ML-0303
iGMDRD116CD4373
iGMDRD532Olaparib2
iGMDRD150RITA3
iGMDRD583LDN 1931891
iGMDRD85Ursolic acid1
iGMDRD237ABT-7513
iGMDRD351GW843682X6
iGMDRD123Isoevodiamine2
iGMDRD177Teniposide7
iGMDRD154NSC237667
iGMDRD883CIL55A5
iGMDRD945ML2143

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PCDH15

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