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iGMDRD307

Canonical SMILES: CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC(=O)NC3=C(CCC3=O)O)O

InChI: InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1

InChI Key: TWWQHCKLTXDWBD-MVTGTTCWSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
Manumycin A	CHEMBL285848	6438330	Alone	Small Molecule

Drug Targets:

FNTA FNTB

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	4
7514	XPO1	1
6664	SOX11	3
6491	STIL	1
132	ADK	3
7750	ZMYM2	2
5546	PRCC	2
10806	SDCCAG8	7
51765	STK26	6
1520	CTSS	4
9706	ULK2	6
3845	KRAS	3
4750	NEK1	3
8266	UBL4A	2
25778	DSTYK	4
65061	CDK15	1
79092	CARD14	3
9475	ROCK2	2
10395	DLC1	2
353345	GPR141	3
3069	HDLBP	3
6657	SOX2	5
390502	SERPINA2	3
5079	PAX5	3
6598	SMARCB1	1
5218	CDK14	1
5298	PI4KB	3
55534	MAML3	3
9816	URB2	3
2249	FGF4	1
1387	CREBBP	8
2043	EPHA4	3
5788	PTPRC	3
2313	FLI1	3
4881	NPR1	3
5579	PRKCB	3
31	ACACA	5
8295	TRRAP	3
7373	COL14A1	3
54567	DLL4	3
10746	MAP3K2	3
23522	KAT6B	2
55728	N4BP2	2
22861	NLRP1	3
440279	UNC13C	5
4610	MYCL	8
5900	RALGDS	3
51776	MAP3K20	1
256646	NUTM1	6
9693	RAPGEF2	1
169436	STKLD1	3
8549	LGR5	1
329	BIRC2	6
22806	IKZF3	3
4005	LMO2	1
9175	MAP3K13	2
80351	TNKS2	3
8313	AXIN2	3
2042	EPHA3	2
730249	ACOD1	3
9636	ISG15	3
2908	NR3C1	1
4739	NEDD9	3
4194	MDM4	1
1984	EIF5A	6
284217	LAMA1	3
83931	STK40	3
6850	SYK	2
287015	TRIM42	2
83983	TSSK6	2
65217	PCDH15	2
23191	CYFIP1	1
783	CACNB2	2
1452	CSNK1A1	5
57510	XPO5	2
6709	SPTAN1	3
8215	DVL1P1	3
50488	MINK1	6
6098	ROS1	4
130497	OSR1	3
3685	ITGAV	2
6917	TCEA1	6
472	ATM	3
139285	AMER1	1
8148	TAF15	2
53942	CNTN5	3
4087	SMAD2	2
1496	CTNNA2	3
5450	POU2AF1	2
2066	ERBB4	2
1029	CDKN2A	5
7184	HSP90B1	2
9794	MAML1	3
5129	CDK18	3
157753	TMEM74	8
3932	LCK	1
7157	TP53	2
6794	STK11	5
2322	FLT3	2
8218	CLTCL1	3
130399	ACVR1C	3
65243	ZFP69B	3
1045	CDX2	2
863	CBFA2T3	6
8874	ARHGEF7	3
5600	MAPK11	1
2309	FOXO3	1
3572	IL6ST	3
57591	MRTFA	2
50945	TBX22	5
676	BRDT	3
9401	RECQL4	3
80205	CHD9	2
3718	JAK3	3
8997	KALRN	7
4437	MSH3	6
170692	ADAMTS18	2
54658	UGT1A1	1
672	BRCA1	2
4139	MARK1	1
546	ATRX	2
5297	PI4KA	1
10926	DBF4	2
30827	CXXC1	3
5578	PRKCA	3
3562	IL3	3
92335	STRADA	3
1000	CDH2	3
1687	GSDME	5
4293	MAP3K9	4
90	ACVR1	2
5366	PMAIP1	1
57154	SMURF1	2
5530	PPP3CA	1
1956	EGFR	1
640	BLK	3
4609	MYC	1
11064	CNTRL	3
90956	ADCK2	3
5789	PTPRD	1
5155	PDGFB	3
4684	NCAM1	1
26278	SACS	2
894	CCND2	5
5156	PDGFRA	2
10000	AKT3	6
93627	TBCK	2
673	BRAF	2
84879	MFSD2A	9
1769	DNAH8	3
23532	PRAME	1
780	DDR1	2
57538	ALPK3	3
8924	HERC2	2
339345	NANOS2	3
100272147	CMC4	6
79184	BRCC3	3
867	CBL	1
6095	RORA	2
29844	TFPT	1
7301	TYRO3	1
93273	LEMD1	3
9113	LATS1	2
460	ASTN1	3
5979	RET	6
8491	MAP4K3	3
55290	BRF2	3
1230	CCR1	3
9509	ADAMTS2	2
8621	CDK13	2
5563	PRKAA2	3
10010	TANK	2
55521	TRIM36	3
1487	CTBP1	4
51592	TRIM33	3
7030	TFE3	2
667	DST	2
3554	IL1R1	5
5305	PIP4K2A	3
1950	EGF	3
8301	PICALM	3
79834	PEAK1	2
5582	PRKCG	2
7465	WEE1	3
55356	SLC22A15	3
85415	RHPN2	4
2277	VEGFD	3
387	RHOA	1
79012	CAMKV	3
9372	ZFYVE9	3
128869	PIGU	1
22843	PPM1E	1
2353	FOS	1
344905	ATP13A5	2
51151	SLC45A2	5
5291	PIK3CB	4
558	AXL	3
53353	LRP1B	1
55289	ACOXL	3
283455	KSR2	2
6093	ROCK1	3
1719	DHFR	3
2131	EXT1	6
57007	ACKR3	6
3717	JAK2	2
22982	DIP2C	2
2157	F8	2
1030	CDKN2B	3
65267	WNK3	3
3552	IL1A	2
80216	ALPK1	4
3656	IRAK2	3
80781	COL18A1	2
2122	MECOM	1
5087	PBX1	6
4217	MAP3K5	3
5584	PRKCI	1
862	RUNX1T1	2
3691	ITGB4	3
5586	PKN2	3
9878	TOX4	3
142	PARP1	2
4040	LRP6	3
3092	HIP1	1
595	CCND1	1
138474	TAF1L	1
6886	TAL1	3
10891	PPARGC1A	7
4629	MYH11	3
7294	TXK	3
6868	ADAM17	1
23112	TNRC6B	2
56155	TEX14	3
5624	PROC	3
5685	PSMA4	3

Gene in drug-gene network: Network Plot

Models in Manumycin A

SITE

DATATYPES

CLASSFICATION

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