CDKN2B
Summary: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase inhibitor 2B | MIM:600431 | Ensembl:ENSG00000147883 | HGNC:HGNC:1788 | PA26321 | 9p21.3 |
GO terms in CDKN2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IDA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | NAS | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | IDA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IMP | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IMP | GO:0007050 | cell cycle arrest |
| BP | IMP | GO:0007093 | mitotic cell cycle checkpoint |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | IEP | GO:0030219 | megakaryocyte differentiation |
| BP | IMP | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0031658 | negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle |
| BP | IMP | GO:0031668 | cellular response to extracellular stimulus |
| BP | IMP | GO:0031670 | cellular response to nutrient |
| BP | IDA | GO:0042326 | negative regulation of phosphorylation |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048536 | spleen development |
| BP | IMP | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IEA | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
Gene expression in normal tissue: CDKN2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKN2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | g1pathway | cell cycle: g1/s check point |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| wikipathways | WP1971 | Integrated Cancer Pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2755 | Transcriptional activity of SMAD2-SMAD3-SMAD4 heterotrimer |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3391 | Senescence-Associated Secretory Phenotype (SASP) |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD379 | BIBR-1532 | 1 |
| iGMDRD213 | SMR000068650 | 5 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD47 | ZM336372 | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD284 | Palbociclib | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 6 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD399 | Selumetinib | 6 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD183 | CDK4/6 inhibitor | 10 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD630 | ML203 | 1 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD554 | CHEMBL1434137 | 4 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKN2B
CLASSFICATION
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