iGMDRD183

Canonical SMILES: CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C

InChI: InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3

InChI Key: HFPLHASLIOXVGS-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameCDK4/6 inhibitor
CHEMBLCHEMBL290904
Pubchem CID481747
Drug StatusFamily
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 8SKINtissue: SKIN cancer: Melanoma (MEL) model num: 3OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 18BRAItissue: BRAI cancer: BRAIN model num: 0BRAINtissue: BRAIN cancer: Glioma model num: 14BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 1BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1

Drug-gene pathway enrichments

8reactome: Signal Transduction7kegg: Pathways in cancer - Homo sapiens (human)7kegg: HTLV-I infection - Homo sapiens (human)7wikipathways: Signaling Pathways in Glioblastoma7reactome: Cell Cycle, Mitotic7reactome: Cell Cycle6biocarta: cyclins and cell cycle regulation6kegg: Viral carcinogenesis - Homo sapiens (human)6wikipathways: G1 to S cell cycle control6kegg: Cellular senescence - Homo sapiens (human)

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2064 ERBB2 2
1029 CDKN2A 18
1031 CDKN2C 1
894 CCND2 2
Showing 1 to 4 of 8 rows

Gene in drug-gene network: Network Plot

Models in CDK4/6 inhibitor

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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