CCND3
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecyclin D3 OMIM IDMIM:123834 Ensembl IDEnsembl:ENSG00000112576 HGNC IDHGNC:HGNC:1585 PHARMGKB IDPA26152 Map Location6p21.1 | |||||
GO terms in CCND3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
Gene expression in normal tissue: CCND3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCND3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCND3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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