CCND3
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin D3 | MIM:123834 | Ensembl:ENSG00000112576 | HGNC:HGNC:1585 | PA26152 | 6p21.1 |
GO terms in CCND3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0042098 | T cell proliferation |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IDA | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0046626 | regulation of insulin receptor signaling pathway |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IDA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016020 | membrane |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: CCND3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCND3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8934593 | Regulation of RUNX1 Expression and Activity |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1545 | miRNAs involved in DNA damage response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3287 | Overview of nanoparticle effects |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP707 | DNA Damage Response |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | e2f_pathway | E2F transcription factor network |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD183 | CDK4/6 inhibitor | 2 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD394 | BX-795 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCND3
CLASSFICATION
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