CDKN2C


Summary: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].

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GO terms in CDKN2C


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
BP IDA GO:0000082 G1/S transition of mitotic cell cycle
BP IDA GO:0007050 cell cycle arrest
BP IDA GO:0008285 negative regulation of cell proliferation
BP IDA GO:0030308 negative regulation of cell growth
BP TAS GO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
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Gene expression in normal tissue: CDKN2C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDKN2C


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Database
Pathway ID
Pathway Des.
biocarta cellcyclepathway cyclins and cell cycle regulation
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-2262752 Cellular responses to stress
reactome R-HSA-2559580 Oxidative Stress Induced Senescence
reactome R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
reactome R-HSA-2559583 Cellular Senescence
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD352 PD-0325901 1
iGMDRD536 PLX-4720 1
iGMDRD748 PHA-665752 1
iGMDRD875 CDK2 inhibitor 14
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDKN2C

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Level
Reference ID
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Cancer
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