CDKN2C
Summary: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase inhibitor 2C | MIM:603369 | Ensembl:ENSG00000123080 | HGNC:HGNC:1789 | PA26322 | 1p32.3 |
GO terms in CDKN2C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IDA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0030308 | negative regulation of cell growth |
| BP | TAS | GO:0031658 | negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0042326 | negative regulation of phosphorylation |
| BP | IEA | GO:0048709 | oligodendrocyte differentiation |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| MF | IDA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: CDKN2C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKN2C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| pid | e2f_pathway | E2F transcription factor network |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD875 | CDK2 inhibitor | 14 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD456 | Crizotinib | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD264 | Bryostatin 1 | 1 |
| iGMDRD183 | CDK4/6 inhibitor | 1 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD478 | ABT-888 | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD284 | Palbociclib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKN2C
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