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iGMDRD133

Canonical SMILES: CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

InChI: InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

InChI Key: BCFGMOOMADDAQU-UHFFFAOYSA-N

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Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Standard NameLapatinib CHEMBLCHEMBL1201179 CHEMBL554 CHEMBL3526325 Pubchem CID208908 KEGG Drug IDD08108 DRUGBANK IDDB01259 Drug StatusAlone Drug targets (TTD)DCL000344 Drug TypeSmall Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Kinase Inhibitor P-glycoprotein/ABCB1 Inhibitors Potential QTc-Prolonging Agents Protein Kinase Inhibitors QTc Prolonging Agents

Drug Targets:

EGFR (P00533)ERBB2 (P04626)

Drug Pathways:

EGFR signaling MAPK signaling pathway ErbB signaling pathway Pathways in cancer Breast cancer

Drug Synonyms:

Lapatinib (INN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

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Gene ID	Gene Name	Model Num.
123036	TC2N	1
55964	SEPT3	1
3845	KRAS	4
250	ALPP	1

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Gene in drug-gene network: Network Plot

Models in Lapatinib

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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