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iGMDRD133

Canonical SMILES: CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

InChI: InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

InChI Key: BCFGMOOMADDAQU-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Lapatinib	CHEMBL1201179 CHEMBL554 CHEMBL3526325	208908	D08108	DB01259	Alone	DCL000344	Small Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Kinase Inhibitor P-glycoprotein/ABCB1 Inhibitors Potential QTc-Prolonging Agents Protein Kinase Inhibitors QTc Prolonging Agents

Drug Targets:

EGFR (P00533)ERBB2 (P04626)

Drug Pathways:

EGFR signaling MAPK signaling pathway ErbB signaling pathway Pathways in cancer Breast cancer

Drug Synonyms:

Lapatinib (INN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
123036	TC2N	1
55964	SEPT3	1
3845	KRAS	4
250	ALPP	1
377007	KLHL30	1
23221	RHOBTB2	1
100130265	ARL2BPP4	1
6597	SMARCA4	1
83481	EPPK1	1
2134	EXTL1	1
4771	NF2	11
23671	TMEFF2	1
3195	TLX1	1
4070	TACSTD2	2
29943	PADI1	1
2520	GAST	1
7158	TP53BP1	1
55294	FBXW7	1
4610	MYCL	1
25937	WWTR1	1
3084	NRG1	1
2707	GJB3	1
4300	MLLT3	1
51343	FZR1	1
23217	ZFR2	1
2064	ERBB2	82
6850	SYK	1
472	ATM	1
22941	SHANK2	1
642587	MIR205HG	1
2066	ERBB4	15
94025	MUC16	1
1029	CDKN2A	2
7157	TP53	1
6794	STK11	1
4292	MLH1	1
100422595	PCMTD1P3	2
8796	SCEL	1
106481809	RN7SKP90	1
121506	ERP27	1
81607	NECTIN4	1
57111	RAB25	1
4089	SMAD4	2
8731	RNMT	3
5290	PIK3CA	2
105375355	UPK3B	1
1956	EGFR	2
4609	MYC	1
51321	AMZ2	1
1031	CDKN2C	1
374286	CDRT1	1
673	BRAF	1
7301	TYRO3	1
2113	ETS1	1
5122	PCSK1	1
5728	PTEN	2
92949	ADAMTSL1	1
5539	PPY	1
1974	EIF4A2	1
53836	GPR87	1
374918	IGFL1	2
55785	FGD6	1
6707	SPRR3	2
54558	SPATA6	1
1912	PHC2	1
26525	IL36RN	1
1027	CDKN1B	1
9635	CLCA2	2
101928337	PTCSC2	2
84951	TNS4	1
3872	KRT17	1
5111	PCNA	1
10848	PPP1R13L	1
26287	ANKRD2	1
3598	IL13RA2	1
1825	DSC3	1
5925	RB1	1
4893	NRAS	1
2065	ERBB3	4
7403	KDM6A	1
287	ANK2	1
595	CCND1	2
4763	NF1	1
7022	TFAP2C	1
4613	MYCN	1
1499	CTNNB1	1
106480676	KRT8P51	2
5624	PROC	2
92747	BPIFB1	1

Gene in drug-gene network: Network Plot

Models in Lapatinib

SITE

DATATYPES

CLASSFICATION

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