SCEL
Summary: The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sciellin | MIM:604112 | Ensembl:ENSG00000136155 | HGNC:HGNC:10573 | PA34986 | 13q22.3 |
GO terms in SCEL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | TAS | GO:0001533 | cornified envelope |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | ISS | GO:0008544 | epidermis development |
| BP | TAS | GO:0008544 | epidermis development |
| BP | IEP | GO:0009612 | response to mechanical stimulus |
| BP | ISS | GO:0009792 | embryo development ending in birth or egg hatching |
| BP | IDA | GO:0030216 | keratinocyte differentiation |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
Gene expression in normal tissue: SCEL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCEL
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD409 | Saracatinib | 2 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD134 | Sorafenib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCEL
CLASSFICATION
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