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iGMDRD134

Canonical SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

InChI: InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

InChI Key: MLDQJTXFUGDVEO-UHFFFAOYSA-N

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Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Standard NameSorafenib CHEMBLCHEMBL1760433 CHEMBL1200485 CHEMBL1336 Pubchem CID216239 KEGG Drug IDD08524 DRUGBANK IDDB00398 Drug StatusAlone Drug targets (TTD)DAP000006 Drug TypeSmall Molecule

Drug Class:

Acids, Heterocyclic Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Benzene Derivatives Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak)Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Hydrocarbons Hydrocarbons, Aromatic Hydrocarbons, Cyclic Immunosuppressive Agents Kinase Inhibitor Miscellaneous Therapeutic Agents Myelosuppressive Agents Nicotinic Acids P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Potential QTc-Prolonging Agents Protein Kinase Inhibitors Pyridines QTc Prolonging Agents raf Kinases Receptors, Vascular Endothelial Growth Factor UGT1A1 Inhibitors Urea Vascular Endothelial Growth Factor Receptor 2 Antagonist

Drug Targets:

BRAF (P15056)RAF1 (P04049)VEGFR FLT4 (P35916)KDR (P35968)FLT3 (P36888)PDGFRB (P09619)KIT (P10721)FGFR1 (P11362)RET (P07949)FLT1 (P17948)

Drug Pathways:

RTK signaling MAPK signaling pathway ErbB signaling pathway VEGF signaling pathway Pathways in cancer Renal cell carcinoma Thyroid cancer Hepatocellular carcinoma

Drug Synonyms:

Sorafenib (USAN/INN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

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Gene ID	Gene Name	Model Num.
259173	ALS2CL	2
8690	JRKL	1
4646	MYO6	1
64761	PARP12	1

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Gene in drug-gene network: Network Plot

Models in Sorafenib

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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