SEARCH

HOME / SEARCH / Sorafenib

iGMDRD134

Canonical SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

InChI: InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

InChI Key: MLDQJTXFUGDVEO-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Sorafenib	CHEMBL1760433 CHEMBL1200485 CHEMBL1336	216239	D08524	DB00398	Alone	DAP000006	Small Molecule

Drug Class:

Acids, Heterocyclic Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Benzene Derivatives Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (weak)Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Hydrocarbons Hydrocarbons, Aromatic Hydrocarbons, Cyclic Immunosuppressive Agents Kinase Inhibitor Miscellaneous Therapeutic Agents Myelosuppressive Agents Nicotinic Acids P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Potential QTc-Prolonging Agents Protein Kinase Inhibitors Pyridines QTc Prolonging Agents raf Kinases Receptors, Vascular Endothelial Growth Factor UGT1A1 Inhibitors Urea Vascular Endothelial Growth Factor Receptor 2 Antagonist

Drug Targets:

BRAF (P15056)RAF1 (P04049)VEGFR FLT4 (P35916)KDR (P35968)FLT3 (P36888)PDGFRB (P09619)KIT (P10721)FGFR1 (P11362)RET (P07949)FLT1 (P17948)

Drug Pathways:

RTK signaling MAPK signaling pathway ErbB signaling pathway VEGF signaling pathway Pathways in cancer Renal cell carcinoma Thyroid cancer Hepatocellular carcinoma

Drug Synonyms:

Sorafenib (USAN/INN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
259173	ALS2CL	2
8690	JRKL	1
4646	MYO6	1
64761	PARP12	1
9791	PTDSS1	1
6189	RPS3A	1
3845	KRAS	5
80017	DGLUCY	1
8573	CASK	1
6597	SMARCA4	1
11160	ERLIN2	2
57169	ZNFX1	1
285489	DOK7	1
4771	NF2	1
858	CAV2	2
56937	PMEPA1	1
25960	ADGRA2	1
3934	LCN2	1
642799	NPIPA2	2
647024	C6orf132	2
5159	PDGFRB	1
4851	NOTCH1	1
55294	FBXW7	1
7307	U2AF1	1
3437	IFIT3	2
6282	S100A11	1
4610	MYCL	1
4300	MLLT3	1
6156	RPL30	1
9052	GPRC5A	2
7428	VHL	1
2064	ERBB2	1
54467	ANKIB1	1
6037	RNASE3	3
1523	CUX1	1
23401	FRAT2	2
148327	CREB3L4	1
80301	PLEKHO2	1
54809	SAMD9	2
1029	CDKN2A	2
7157	TP53	2
6794	STK11	1
2322	FLT3	22
3791	KDR	3
4292	MLH1	1
64129	TINAGL1	2
4086	SMAD1	1
7422	VEGFA	1
369	ARAF	8
8796	SCEL	1
3433	IFIT2	2
116447	TOP1MT	1
4089	SMAD4	1
56997	COQ8A	1
8731	RNMT	2
5290	PIK3CA	1
2202	EFEMP1	1
6277	S100A6	1
11212	PLPBP	2
4609	MYC	1
7328	UBE2H	1
6122	RPL3	1
283358	B4GALNT3	1
1031	CDKN2C	1
5156	PDGFRA	1
673	BRAF	9
6129	RPL7	1
406956	MIR181B2	1
170463	SSBP4	1
5979	RET	1
9367	RAB9A	1
7286	TUFT1	1
55290	BRF2	1
5728	PTEN	1
3675	ITGA3	2
4736	RPL10A	1
359845	RFLNB	2
79571	GCC1	2
440021	KRTAP5-2	1
57707	TLDC1	1
7057	THBS1	1
78991	PCYOX1L	1
140680	C20orf96	1
6083	SNORD21	1
3096	HIVEP1	1
90102	PHLDB2	1
8842	PROM1	1
330	BIRC3	2
3815	KIT	51
132299	OCIAD2	2
5925	RB1	1
4893	NRAS	4
3691	ITGB4	1
7403	KDM6A	1
100873312	RNA5SP78	1
59277	NTN4	2
57153	SLC44A2	2
595	CCND1	2
4763	NF1	3
4613	MYCN	1
5493	PPL	1
83871	RAB34	1
2178	FANCE	2
1499	CTNNB1	1
3162	HMOX1	1
257397	TAB3	1
5624	PROC	1
79872	CBLL1	1

Gene in drug-gene network: Network Plot

Models in Sorafenib

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.