PLPBP
Summary: This gene encodes a pyridoxal 5'-phosphate binding protein involved in the homeostatic regulation of intracellular pyridoxal 5'-phosphate. This gene has a tumor suppressive effect on hepatocellular carcinoma and other solid tumors of epithelial origin. Naturally occurring mutations in this gene are associated with a pyridoxine-dependent epilepsy. [provided by RefSeq, Mar 2017].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604436 Ensembl IDEnsembl:ENSG00000147471 HGNC IDHGNC:HGNC:9457 PHARMGKB IDPA33810 Map Location8p11.23 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in PLPBP
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005622 | intracellular |
| CC | IDA | GO:0005622 | intracellular |
| CC | NAS | GO:0005737 | cytoplasm |
| BP | ND | GO:0008150 | biological_process |
| MF | IBA | GO:0030170 | pyridoxal phosphate binding |
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Gene expression in normal tissue: PLPBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLPBP
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD134 | Sorafenib | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLPBP
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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