UBE2H
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin conjugating enzyme E2 H | MIM:601082 | Ensembl:ENSG00000186591 | HGNC:HGNC:12484 | PA37133 | 7q32.2 |
GO terms in UBE2H
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0070936 | protein K48-linked ubiquitination |
| BP | IDA | GO:0070979 | protein K11-linked ubiquitination |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0061631 | ubiquitin conjugating enzyme activity |
| MF | IEA | GO:0061631 | ubiquitin conjugating enzyme activity |
Gene expression in normal tissue: UBE2H
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBE2H
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| humancyc | PWY-7511 | protein ubiquitylation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UBE2H
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