UBE2H


Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ubiquitin conjugating enzyme E2 HMIM:601082Ensembl:ENSG00000186591HGNC:HGNC:12484PA371337q32.2

GO terms in UBE2H


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005829cytosol
BPIBAGO:0006511ubiquitin-dependent protein catabolic process
BPTASGO:0006511ubiquitin-dependent protein catabolic process
BPTASGO:0016567protein ubiquitination
BPIEAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIDAGO:0070936protein K48-linked ubiquitination
BPIDAGO:0070979protein K11-linked ubiquitination
MFIDAGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0061631ubiquitin conjugating enzyme activity
MFIEAGO:0061631ubiquitin conjugating enzyme activity

Gene expression in normal tissue: UBE2H

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UBE2H


DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8852135Protein ubiquitination
reactomeR-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymes
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
humancycPWY-7511protein ubiquitylation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD134Sorafenib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UBE2H

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