SEARCH

HOME / SEARCH / TOP1MT

TOP1MT

Summary: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
DNA topoisomerase I mitochondrial	MIM:606387	Ensembl:ENSG00000184428	HGNC:HGNC:29787	PA134922772	8q24.3

Gene Categories:

DRUGGABLE GENOME

GO terms in TOP1MT

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005634	nucleus
CC	IBA	GO:0005730	nucleolus
CC	IDA	GO:0005739	mitochondrion
CC	IBA	GO:0031298	replication fork protection complex
CC	IBA	GO:0042645	mitochondrial nucleoid
CC	IDA	GO:0042645	mitochondrial nucleoid
BP	IBA	GO:0006260	DNA replication
BP	IBA	GO:0006265	DNA topological change
BP	IBA	GO:0006338	chromatin remodeling
BP	IBA	GO:0007059	chromosome segregation
MF	IEA	GO:0003677	DNA binding
MF	IBA	GO:0003917	DNA topoisomerase type I activity

Gene expression in normal tissue: TOP1MT

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOP1MT

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	1
iGMDRD190	Nilotinib	1
iGMDRD134	Sorafenib	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOP1MT

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.