TOP1MT

Summary: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameDNA topoisomerase I mitochondrial
OMIM IDMIM:606387
Ensembl IDEnsembl:ENSG00000184428
HGNC IDHGNC:HGNC:29787
PHARMGKB IDPA134922772
Map Location8q24.3

Gene Categories:

DRUGGABLE GENOME

GO terms in TOP1MT


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC IBA GO:0005730 nucleolus
CC IDA GO:0005739 mitochondrion
CC IBA GO:0031298 replication fork protection complex
CC IBA GO:0042645 mitochondrial nucleoid
CC IDA GO:0042645 mitochondrial nucleoid
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Gene expression in normal tissue: TOP1MT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOP1MT


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
iGMDRD190 Nilotinib 1
iGMDRD134 Sorafenib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOP1MT

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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