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MYCN

Summary: This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameMYCN proto-oncogene, bHLH transcription factor OMIM IDMIM:164840 Ensembl IDEnsembl:ENSG00000134323 HGNC IDHGNC:HGNC:7559 PHARMGKB IDPA31359 Map Location2p24.3

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in MYCN

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF	TAS	GO:0003677	DNA binding

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Gene expression in normal tissue: MYCN

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYCN

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Database	Pathway ID	Pathway Des.
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP3651	Pathways Affected in Adenoid Cystic Carcinoma

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD352	PD-0325901	1
iGMDRD536	PLX-4720	1
iGMDRD178	MG-132	1
iGMDRD945	ML214	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYCN

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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