BRAF
Summary: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:164757 Ensembl IDEnsembl:ENSG00000157764 HGNC IDHGNC:HGNC:1097 PHARMGKB IDPA25408 Map Location7q34 | |||||
GO terms in BRAF
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0009887 | animal organ morphogenesis |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
Gene expression in normal tissue: BRAF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BRAF
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | mtor_4pathway | mTOR signaling pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRAF
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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