BRAF


Summary: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
B-Raf proto-oncogene, serine/threonine kinaseMIM:164757Ensembl:ENSG00000157764HGNC:HGNC:1097PA254087q34

GO terms in BRAF


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000165MAPK cascade
BPTASGO:0000165MAPK cascade
BPIEAGO:0000186activation of MAPKK activity
BPIDAGO:0006468protein phosphorylation
BPTASGO:0009887animal organ morphogenesis
BPIMPGO:0010628positive regulation of gene expression
BPIDAGO:0010828positive regulation of glucose transmembrane transport
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIDAGO:0043066negative regulation of apoptotic process
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070413trehalose metabolism in response to stress
BPIDAGO:0071277cellular response to calcium ion
BPIDAGO:0090150establishment of protein localization to membrane
CCIEAGO:0005634nucleus
CCIBAGO:0005739mitochondrion
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0043231intracellular membrane-bounded organelle
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0031267small GTPase binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: BRAF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BRAF


DatabasePathway IDPathway Des.
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcdc42_pathwayCDC42 signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidmtor_4pathwaymTOR signaling pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidtcrraspathwayRas signaling in the CD4+ TCR pathway
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pharmgkbPA165959425Pathway_PA165959425
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
netpathPathway_EGFR1EGFR1
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP2571Polycystic Kidney Disease Pathway
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3676BDNF-TrkB Signaling
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP422MAPK Cascade
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP712Estrogen signaling pathway
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP734Serotonin Receptor 4-6-7 and NR3C Signaling
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1295596Spry regulation of FGF signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-169893Prolonged ERK activation events
reactomeR-HSA-170968Frs2-mediated activation
reactomeR-HSA-170984ARMS-mediated activation
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187706Signalling to p38 via RIT and RIN
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654727Negative regulation of FGFR2 signaling
reactomeR-HSA-5654732Negative regulation of FGFR3 signaling
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5674499Negative feedback regulation of MAPK pathway
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832404
iGMDRD498GW441756X1
iGMDRD3615Z-7-Oxozeaenol3
iGMDRD599Salermide6
iGMDRD559TAK-7331
iGMDRD494Neopeltolide1
iGMDRD354Midostaurin1
iGMDRD100Zebularine2
iGMDRD692SB5908856
iGMDRD291AC1NS4S01
iGMDRD640CAY106181
iGMDRD268Cerulenin2
iGMDRD480KU00606482
iGMDRD138PX 121
iGMDRD852BRD-K356044181
iGMDRD862BRD-K949913781
iGMDRD134Sorafenib9
iGMDRD440Nutlin-3A1
iGMDRD30917AAG2
iGMDRD727Alpelisib1
iGMDRD85Ursolic acid3
iGMDRD536PLX-472018
iGMDRD57Chloropentafluorobenzene3
iGMDRD307Manumycin A2
iGMDRD512nutlin 35
iGMDRD410Ko-1432
iGMDRD792Cetuximab15
iGMDRD424Tamatinib5
iGMDRD32Metformin1
iGMDRD500Cobimetinib91
iGMDRD652UNC06381
iGMDRD837Bevacizumab1
iGMDRD882CIL414
iGMDRD3PD-1730741
iGMDRD967Panitumumab21
iGMDRD544Vismodegib (GDC-0449)1
iGMDRD269Purmorphamine2
iGMDRD695FR-1802042
iGMDRD1016THZ-2-491
iGMDRD785XMD15-271
iGMDRD514ERK inhibitor4
iGMDRD6AM-5804
iGMDRD88AICA ribonucleotide1
iGMDRD434BMS-5369242
iGMDRD481Dactolisib2
iGMDRD333MEK Inhibitor17
iGMDRD231Importazole4
iGMDRD61Kinetin riboside3
iGMDRD748PHA-6657521
iGMDRD470Trametinib247
iGMDRD409Saracatinib1
iGMDRD12Bicalutamide1
iGMDRD670ML 2104
iGMDRD483SCH-5290746
iGMDRD133Lapatinib1
iGMDRD888Compound 447
iGMDRD851BRD-K342228891
iGMDRD838BGB6592
iGMDRD23Gossypol2
iGMDRD247Blebbistatin4
iGMDRD920HSP90 inhibitor2
iGMDRD207Capsaicin3
iGMDRD816anti-EGFR mAbs3
iGMDRD226ML0064
iGMDRD468AZ6284
iGMDRD187BRD98761
iGMDRD698Neratinib4
iGMDRD352PD-03259013
iGMDRD237ABT-7513
iGMDRD154NSC237665
iGMDRD719IOX22
iGMDRD276AS 6052401
iGMDRD871BRD63681
iGMDRD367Ro 28-16751
iGMDRD147Prima-15
iGMDRD534BRD14294
iGMDRD264Bryostatin 11
iGMDRD293Bleomycin1
iGMDRD137Indisulam3
iGMDRD265Dacarbazine1
iGMDRD311Dacinostat2
iGMDRD213SMR0000686504
iGMDRD608Refametinib9
iGMDRD201SKI II2
iGMDRD163all trans Retinoic Acid1
iGMDRD401Afatinib4
iGMDRD235SNS-0321
iGMDRD83Capecitabine1
iGMDRD136Nutlin-31
iGMDRD554CHEMBL14341376
iGMDRD313Axitinib1
iGMDRD229B024
iGMDRD387CHIR-990213
iGMDRD659Avagacestat (BMS-708163)1
iGMDRD239Dasatinib4
iGMDRD180CDK2/4 inhibitor2
iGMDRD596Vemurafenib346
iGMDRD332A-7700411
iGMDRD577BIX012944
iGMDRD570MLS0060110511
iGMDRD131Erlotinib1
iGMDRD509NVP-BHG7121
iGMDRD491TAE-6841
iGMDRD613CHEMBL2581483
iGMDRD109Gefitinib1
iGMDRD573GSK-1904529A1
iGMDRD782DC-45-A26
iGMDRD318PAC-11
iGMDRD870BRD636102
iGMDRD178MG-1321
iGMDRD486Tosedostat1
iGMDRD858BRD-K719354681
iGMDRD614Dabrafenib371
iGMDRD456Crizotinib2
iGMDRD299ICL 6704
iGMDRD701NVP-AUY9222
iGMDRD232FTI-2772
iGMDRD80Irinotecan1
iGMDRD472PF-5622712
iGMDRD505Pevonedistat6
iGMDRD300Tozasertib2
iGMDRD935JQ121
iGMDRD353PD03259015
iGMDRD990PL.DI1
iGMDRD271Brefeldin A4
iGMDRD68Paclitaxel1
iGMDRD389SB5253341
iGMDRD415LE-1354
iGMDRD504Obatoclax2
iGMDRD381Rucaparib1
iGMDRD107Valdecoxib1
iGMDRD2PK-111952
iGMDRD152179324-69-71
iGMDRD860BRD-K903700281
iGMDRD394BX-7951
iGMDRD443Linifanib1
iGMDRD420Leucascandrolide A4
iGMDRD779PRL-3 Inhibitor I4
iGMDRD781Sirolimus5
iGMDRD899EGFR TK inhibitor6
iGMDRD188Piperlongumine1
iGMDRD338MEK Inhibitor in EGFR mutant1
iGMDRD399Selumetinib13
iGMDRD190Nilotinib1
iGMDRD41Imatinib1
iGMDRD874BRD89584
iGMDRD513BML-2594
iGMDRD449RO49876552
iGMDRD983PI3K pathway inhibitor5
iGMDRD117Docetaxel1
iGMDRD284Palbociclib1
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD44Temozolomide1
iGMDRD461VX-11e2
iGMDRD341Triacsin c3
iGMDRD605AZD64821
iGMDRD511CHEMBL3993794
iGMDRD248BRD43544
iGMDRD324CI-10405
iGMDRD532Olaparib4
iGMDRD520Pictilisib1
iGMDRD150RITA1
iGMDRD1036X17AAG1
iGMDRD327LBH-5891
iGMDRD339MEK Inhibitor enhanced radioiodine uptake1
iGMDRD839BRAF inhibitor29
iGMDRD286Nsc 6328391
iGMDRD968Pan-RAF inhibitor10
iGMDRD329Merck601
iGMDRD561ABT-2631
iGMDRD245FH5352
iGMDRD766LY30091201
iGMDRD705Nakiterpiosin1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BRAF

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