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iGMDRD313

Canonical SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4

InChI: InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

InChI Key: RITAVMQDGBJQJZ-FMIVXFBMSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Axitinib	CHEMBL1289926	6450550	DB06626	Alone	Small Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents Azoles Cytochrome P-450 CYP1A2 Substrates Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Kinase Inhibitor OATP1B1/SLCO1B1 Substrates P-glycoprotein/ABCB1 Substrates Protein Kinase Inhibitors Pyrazoles UGT1A1 Substrates

Drug Targets:

FLT1 (P17948)KDR (P35968)FLT4 (P35916)PDGFR KIT VEGFR

Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
7514	XPO1	1
2956	MSH6	1
103	ADAR	2
3845	KRAS	1
6597	SMARCA4	1
6598	SMARCB1	1
29126	CD274	1
11200	CHEK2	1
5159	PDGFRB	1
7158	TP53BP1	1
238	ALK	1
7428	VHL	1
54464	XRN1	1
92	ACVR2A	1
10413	YAP1	1
3791	KDR	1
57111	RAB25	1
4089	SMAD4	1
3553	IL1B	1
5156	PDGFRA	1
673	BRAF	1
171023	ASXL1	2
8821	INPP4B	2
5894	RAF1	1
3815	KIT	1
2065	ERBB3	1
25	ABL1	2
94	ACVRL1	1

Gene in drug-gene network: Network Plot

Models in Axitinib

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.