SMARCA4


Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4MIM:603254Ensembl:ENSG00000127616HGNC:HGNC:11100PA3595019p13.2

GO terms in SMARCA4


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFHDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFIDAGO:0001164RNA polymerase I CORE element sequence-specific DNA binding
MFIPIGO:0002039p53 binding
MFIDAGO:0003713transcription coactivator activity
MFIMPGO:0003713transcription coactivator activity
MFNASGO:0003713transcription coactivator activity
MFIDAGO:0003714transcription corepressor activity
MFIEAGO:0003723RNA binding
MFIEAGO:0004386helicase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIGIGO:0008094DNA-dependent ATPase activity
MFIPIGO:0008134transcription factor binding
MFIPIGO:0030957Tat protein binding
MFHDAGO:0031492nucleosomal DNA binding
MFIPIGO:0047485protein N-terminus binding
MFIPIGO:0050681androgen receptor binding
MFIPIGO:0070182DNA polymerase binding
MFIDAGO:0070577lysine-acetylated histone binding
CCHDAGO:0000790nuclear chromatin
CCIDAGO:0000790nuclear chromatin
CCHDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCHDAGO:0016020membrane
CCIDAGO:0016514SWI/SNF complex
CCHDAGO:0032991protein-containing complex
CCIDAGO:0071564npBAF complex
CCISSGO:0071564npBAF complex
CCISSGO:0071565nBAF complex
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001188RNA polymerase I transcriptional preinitiation complex assembly
BPIEPGO:0003407neural retina development
BPTASGO:0006325chromatin organization
BPIDAGO:0006337nucleosome disassembly
BPICGO:0006338chromatin remodeling
BPIDAGO:0006338chromatin remodeling
BPIMPGO:0006338chromatin remodeling
BPNASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0007399nervous system development
BPIMPGO:0030177positive regulation of Wnt signaling pathway
BPIMPGO:0030308negative regulation of cell growth
BPTASGO:0038111interleukin-7-mediated signaling pathway
BPHDAGO:0043044ATP-dependent chromatin remodeling
BPIMPGO:0043923positive regulation by host of viral transcription
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIMPGO:0060766negative regulation of androgen receptor signaling pathway
BPIMPGO:1901838positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
BPIDAGO:1902661positive regulation of glucose mediated signaling pathway
BPIMPGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPTASGO:1904837beta-catenin-TCF complex assembly

Gene expression in normal tissue: SMARCA4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SMARCA4


DatabasePathway IDPathway Des.
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP3527Preimplantation Embryo
wikipathwaysWP3657Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathwaysWP4204Tumor suppressor activity of SMARCB1
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
piderb_genomic_pathwayValidated nuclear estrogen receptor beta network
pidp53downstreampathwayDirect p53 effectors
pidrb_1pathwayRegulation of retinoblastoma protein
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
netpathPathway_TNFalphaTNFalpha
biocartahswisnfpathwaychromatin remodeling by hswi/snf atp-dependent complexes
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3214858RMTs methylate histone arginines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD356PNU-746541
iGMDRD190Nilotinib1
iGMDRD146Elesclomol1
iGMDRD888Compound 443
iGMDRD399Selumetinib1
iGMDRD188Piperlongumine3
iGMDRD133Lapatinib1
iGMDRD593CX-54611
iGMDRD187BRD98761
iGMDRD52Rotenone2
iGMDRD294Batimastat1
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD1019TL-2-1051
iGMDRD284Palbociclib1
iGMDRD474Avrainvillamide3
iGMDRD1593-Chloro-L-alanine2
iGMDRD394BX-7952
iGMDRD152179324-69-75
iGMDRD748PHA-6657521
iGMDRD61Kinetin riboside8
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD670ML 2101
iGMDRD546BMS-7548071
iGMDRD476WH-4-0231
iGMDRD427ABT7378
iGMDRD749ZINC67184531
iGMDRD420Leucascandrolide A1
iGMDRD889Compound 7d-cis2
iGMDRD409Saracatinib1
iGMDRD126Tipifarnib3
iGMDRD662JQ-12
iGMDRD286Nsc 6328393
iGMDRD871BRD63686
iGMDRD705Nakiterpiosin4
iGMDRD402AKT Inhibitor VIII1
iGMDRD293Bleomycin3
iGMDRD121GMX17783
iGMDRD137Indisulam2
iGMDRD883CIL55A2
iGMDRD605AZD64821
iGMDRD123Isoevodiamine1
iGMDRD698Neratinib2
iGMDRD352PD-03259011
iGMDRD775NCGC00346967-011
iGMDRD49Mitomycin1
iGMDRD341Triacsin c6
iGMDRD79Gemcitabine2
iGMDRD405PIK-752
iGMDRD560MK-22062
iGMDRD584VER 1550083
iGMDRD719IOX21
iGMDRD330BRD41321
iGMDRD451Serdemetan3
iGMDRD131Erlotinib1
iGMDRD364CP-7247141
iGMDRD562Navitoclax2
iGMDRD577BIX012945
iGMDRD185DMOG1
iGMDRD100Zebularine2
iGMDRD870BRD636101
iGMDRD30917AAG2
iGMDRD574Ruxolitinib1
iGMDRD441TW 371
iGMDRD440Nutlin-3A1
iGMDRD885Compound 1101
iGMDRD782DC-45-A21
iGMDRD134Sorafenib1
iGMDRD33Entinostat1
iGMDRD907EZH2 inhibitor3
iGMDRD491TAE-6841
iGMDRD298L-6854581
iGMDRD130Enzastaurin1
iGMDRD634SCHEMBL26080412
iGMDRD280CYTOCHALASIN B5
iGMDRD297Austocystin D6
iGMDRD686PF47086711
iGMDRD281Vinorelbine base1
iGMDRD498GW441756X1
iGMDRD494Neopeltolide1
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD144NSC953978
iGMDRD772BRD47701
iGMDRD599Salermide1
iGMDRD313Axitinib1
iGMDRD210AC556493
iGMDRD136Nutlin-31
iGMDRD695FR-1802041
iGMDRD384EHT-18641
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat5
iGMDRD269Purmorphamine2
iGMDRD872BRD71374
iGMDRD414MST-3126
iGMDRD68Paclitaxel1
iGMDRD481Dactolisib2
iGMDRD192CIL561
iGMDRD434BMS-5369244
iGMDRD139Fumagillol1
iGMDRD132(-)-gallocatechin-3-O-gallate5
iGMDRD901ELCPK2
iGMDRD536PLX-47201
iGMDRD57Chloropentafluorobenzene6
iGMDRD85Ursolic acid2
iGMDRD701NVP-AUY9221
iGMDRD160Cis-Platin1
iGMDRD424Tamatinib2
iGMDRD456Crizotinib1
iGMDRD148Pifithrin-mu1
iGMDRD512nutlin 35
iGMDRD347Y-399831
iGMDRD792Cetuximab1
iGMDRD486Tosedostat1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMARCA4

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