iGMDRD356
| Standard Name | CHEMBL | Pubchem CID | Drug Status | Drug Type |
|---|---|---|---|---|
| PNU-74654 | CHEMBL254381 | 9836740 | Alone | Small Molecule |
Drug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 4854 | NOTCH3 | 1 |
| 8999 | CDKL2 | 1 |
| 8019 | BRD3 | 2 |
| 10221 | TRIB1 | 3 |
| 6491 | STIL | 2 |
| 8444 | DYRK3 | 2 |
| 9261 | MAPKAPK2 | 3 |
| 132 | ADK | 3 |
| 6774 | STAT3 | 3 |
| 11183 | MAP4K5 | 2 |
| 114801 | TMEM200A | 2 |
| 2339 | FNTA | 1 |
| 3845 | KRAS | 1 |
| 4750 | NEK1 | 2 |
| 5295 | PIK3R1 | 2 |
| 6351 | CCL4 | 1 |
| 80070 | ADAMTS20 | 1 |
| 8573 | CASK | 2 |
| 6938 | TCF12 | 2 |
| 1263 | PLK3 | 2 |
| 9475 | ROCK2 | 3 |
| 6597 | SMARCA4 | 1 |
| 9869 | SETDB1 | 2 |
| 5133 | PDCD1 | 1 |
| 843 | CASP10 | 3 |
| 3069 | HDLBP | 2 |
| 11116 | FGFR1OP | 1 |
| 7444 | VRK2 | 2 |
| 5754 | PTK7 | 2 |
| 64783 | RBM15 | 3 |
| 23235 | SIK2 | 5 |
| 10863 | ADAM28 | 3 |
| 4170 | MCL1 | 3 |
| 1136 | CHRNA3 | 3 |
| 1607 | DGKB | 1 |
| 7253 | TSHR | 3 |
| 27 | ABL2 | 3 |
| 2241 | FER | 1 |
| 1404 | HAPLN1 | 2 |
| 84299 | MIEN1 | 2 |
| 80122 | MAP3K19 | 1 |
| 55023 | PHIP | 3 |
| 1859 | DYRK1A | 3 |
| 5788 | PTPRC | 1 |
| 51755 | CDK12 | 2 |
| 5596 | MAPK4 | 2 |
| 5966 | REL | 3 |
| 3604 | TNFRSF9 | 2 |
| 29998 | BICRA | 2 |
| 5159 | PDGFRB | 3 |
| 7173 | TPO | 2 |
| 5465 | PPARA | 3 |
| 55294 | FBXW7 | 1 |
| 2033 | EP300 | 2 |
| 641 | BLM | 2 |
| 10006 | ABI1 | 3 |
| 54477 | PLEKHA5 | 1 |
| 57396 | CLK4 | 1 |
| 5900 | RALGDS | 3 |
| 342977 | NANOS3 | 1 |
| 7025 | NR2F1 | 1 |
| 3556 | IL1RAP | 3 |
| 22806 | IKZF3 | 1 |
| 10342 | TFG | 3 |
| 166614 | DCLK2 | 1 |
| 22984 | PDCD11 | 2 |
| 9175 | MAP3K13 | 1 |
| 8313 | AXIN2 | 4 |
| 6733 | SRPK2 | 3 |
| 6091 | ROBO1 | 2 |
| 2260 | FGFR1 | 3 |
| 199699 | DAND5 | 1 |
| 23255 | MTCL1 | 2 |
| 80129 | CCDC170 | 3 |
| 10188 | TNK2 | 2 |
| 2736 | GLI2 | 2 |
| 83990 | BRIP1 | 1 |
| 51804 | SIX4 | 2 |
| 3688 | ITGB1 | 3 |
| 269 | AMHR2 | 1 |
| 55681 | SCYL2 | 1 |
| 4982 | TNFRSF11B | 2 |
| 238 | ALK | 2 |
| 375449 | MAST4 | 5 |
| 22858 | ICK | 2 |
| 65266 | WNK4 | 2 |
| 57476 | GRAMD1B | 2 |
| 8395 | PIP5K1B | 2 |
| 54899 | PXK | 1 |
| 29775 | CARD10 | 3 |
| 23191 | CYFIP1 | 2 |
| 783 | CACNB2 | 1 |
| 9759 | HDAC4 | 2 |
| 8714 | ABCC3 | 3 |
| 6709 | SPTAN1 | 2 |
| 6464 | SHC1 | 3 |
| 659 | BMPR2 | 3 |
| 3667 | IRS1 | 2 |
| 139285 | AMER1 | 2 |
| 83903 | HASPIN | 2 |
| 8148 | TAF15 | 3 |
| 28996 | HIPK2 | 3 |
| 575 | ADGRB1 | 3 |
| 5924 | RASGRF2 | 1 |
| 7010 | TEK | 4 |
| 5450 | POU2AF1 | 4 |
| 898 | CCNE1 | 3 |
| 23152 | CIC | 3 |
| 7184 | HSP90B1 | 3 |
| 9794 | MAML1 | 3 |
| 27436 | EML4 | 1 |
| 3236 | HOXD10 | 1 |
| 9874 | TLK1 | 3 |
| 28514 | DLL1 | 3 |
| 7157 | TP53 | 1 |
| 6092 | ROBO2 | 2 |
| 6794 | STK11 | 1 |
| 4857 | NOVA1 | 3 |
| 8218 | CLTCL1 | 2 |
| 397 | ARHGDIB | 1 |
| 5910 | RAP1GDS1 | 3 |
| 4292 | MLH1 | 2 |
| 2263 | FGFR2 | 1 |
| 1019 | CDK4 | 3 |
| 4869 | NPM1 | 2 |
| 863 | CBFA2T3 | 1 |
| 9088 | PKMYT1 | 1 |
| 55589 | BMP2K | 3 |
| 136332 | LRGUK | 2 |
| 652 | BMP4 | 3 |
| 5650 | KLK7 | 2 |
| 7175 | TPR | 1 |
| 80205 | CHD9 | 2 |
| 2081 | ERN1 | 3 |
| 23269 | MGA | 1 |
| 6280 | S100A9 | 3 |
| 2175 | FANCA | 1 |
| 4089 | SMAD4 | 1 |
| 51284 | TLR7 | 3 |
| 672 | BRCA1 | 3 |
| 7204 | TRIO | 2 |
| 78989 | COLEC11 | 2 |
| 23373 | CRTC1 | 3 |
| 285220 | EPHA6 | 2 |
| 3417 | IDH1 | 1 |
| 23678 | SGK3 | 3 |
| 5297 | PI4KA | 3 |
| 5069 | PAPPA | 3 |
| 5578 | PRKCA | 2 |
| 286133 | SCARA5 | 3 |
| 3702 | ITK | 4 |
| 9972 | NUP153 | 2 |
| 3562 | IL3 | 1 |
| 3720 | JARID2 | 2 |
| 1514 | CTSL | 2 |
| 2931 | GSK3A | 1 |
| 5034 | P4HB | 3 |
| 26524 | LATS2 | 1 |
| 7043 | TGFB3 | 3 |
| 2318 | FLNC | 2 |
| 64919 | BCL11B | 1 |
| 2030 | SLC29A1 | 3 |
| 7075 | TIE1 | 2 |
| 1956 | EGFR | 6 |
| 11064 | CNTRL | 2 |
| 4684 | NCAM1 | 2 |
| 26278 | SACS | 5 |
| 6776 | STAT5A | 2 |
| 51265 | CDKL3 | 2 |
| 6446 | SGK1 | 3 |
| 5156 | PDGFRA | 2 |
| 204851 | HIPK1 | 3 |
| 203102 | ADAM32 | 4 |
| 7153 | TOP2A | 3 |
| 57082 | KNL1 | 1 |
| 1769 | DNAH8 | 1 |
| 4863 | NPAT | 2 |
| 83452 | RAB33B | 3 |
| 120892 | LRRK2 | 2 |
| 84441 | MAML2 | 2 |
| 9113 | LATS1 | 1 |
| 8178 | ELL | 3 |
| 9321 | TRIP11 | 2 |
| 664 | BNIP3 | 1 |
| 4853 | NOTCH2 | 4 |
| 9509 | ADAMTS2 | 3 |
| 23049 | SMG1 | 1 |
| 8312 | AXIN1 | 3 |
| 10752 | CHL1 | 3 |
| 23476 | BRD4 | 3 |
| 1487 | CTBP1 | 3 |
| 8888 | MCM3AP | 2 |
| 4914 | NTRK1 | 2 |
| 667 | DST | 2 |
| 115701 | ALPK2 | 2 |
| 352909 | DNAAF3 | 1 |
| 6146 | RPL22 | 1 |
| 658 | BMPR1B | 3 |
| 7273 | TTN | 1 |
| 1445 | CSK | 3 |
| 7454 | WAS | 3 |
| 85415 | RHPN2 | 2 |
| 23389 | MED13L | 2 |
| 29959 | NRBP1 | 2 |
| 54904 | NSD3 | 3 |
| 387 | RHOA | 2 |
| 29941 | PKN3 | 3 |
| 55561 | CDC42BPG | 3 |
| 10249 | GLYAT | 2 |
| 8821 | INPP4B | 3 |
| 221895 | JAZF1 | 2 |
| 5532 | PPP3CB | 2 |
| 22843 | PPM1E | 3 |
| 286151 | FBXO43 | 2 |
| 1662 | DDX10 | 1 |
| 1643 | DDB2 | 1 |
| 54738 | FEV | 1 |
| 57680 | CHD8 | 2 |
| 10111 | RAD50 | 1 |
| 5395 | PMS2 | 2 |
| 55289 | ACOXL | 2 |
| 3181 | HNRNPA2B1 | 1 |
| 9659 | PDE4DIP | 3 |
| 4000 | LMNA | 2 |
| 54101 | RIPK4 | 2 |
| 5927 | KDM5A | 3 |
| 5587 | PRKD1 | 1 |
| 5583 | PRKCH | 1 |
| 900 | CCNG1 | 3 |
| 6778 | STAT6 | 2 |
| 4067 | LYN | 2 |
| 8428 | STK24 | 3 |
| 3552 | IL1A | 3 |
| 80216 | ALPK1 | 3 |
| 5932 | RBBP8 | 2 |
| 3977 | LIFR | 1 |
| 4330 | MN1 | 1 |
| 2122 | MECOM | 2 |
| 2903 | GRIN2A | 1 |
| 5925 | RB1 | 2 |
| 4217 | MAP3K5 | 1 |
| 862 | RUNX1T1 | 2 |
| 7403 | KDM6A | 1 |
| 54790 | TET2 | 3 |
| 7508 | XPC | 2 |
| 4638 | MYLK | 2 |
| 4205 | MEF2A | 2 |
| 30849 | PIK3R4 | 1 |
| 3480 | IGF1R | 1 |
| 11086 | ADAM29 | 1 |
| 2261 | FGFR3 | 2 |
| 4040 | LRP6 | 3 |
| 55746 | NUP133 | 1 |
| 8321 | FZD1 | 3 |
| 4763 | NF1 | 3 |
| 57697 | FANCM | 2 |
| 1612 | DAPK1 | 2 |
| 55791 | LRIF1 | 3 |
| 1840 | DTX1 | 3 |
| 4286 | MITF | 3 |
| 4593 | MUSK | 2 |
| 4629 | MYH11 | 1 |
| 23683 | PRKD3 | 3 |
| 1608 | DGKG | 2 |
| 4193 | MDM2 | 1 |
| 1795 | DOCK3 | 3 |
| 5970 | RELA | 2 |
| 1488 | CTBP2 | 2 |
Gene in drug-gene network: Network Plot
Models in PNU-74654
CLASSFICATION
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