ADAMTS20


Summary: The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADAM metallopeptidase with thrombospondin type 1 motif 20MIM:611681Ensembl:ENSG00000173157HGNC:HGNC:17178PA13490162612q12

GO terms in ADAMTS20


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006508proteolysis
BPIEAGO:0009967positive regulation of signal transduction
BPIEAGO:0030198extracellular matrix organization
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0045636positive regulation of melanocyte differentiation
CCIEAGO:0005615extracellular space
CCTASGO:0062023collagen-containing extracellular matrix
MFIEAGO:0004222metalloendopeptidase activity
MFIEAGO:0008270zinc ion binding

Gene expression in normal tissue: ADAMTS20

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAMTS20


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-5173214O-glycosylation of TSR domain-containing proteins
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide7
iGMDRD705Nakiterpiosin1
iGMDRD121GMX17782
iGMDRD158NSC1415402
iGMDRD202Curcumin3
iGMDRD147Prima-11
iGMDRD329Merck602
iGMDRD367Ro 28-16754
iGMDRD871BRD63683
iGMDRD523Cyanoquinoline, 116
iGMDRD584VER 1550081
iGMDRD330BRD41323
iGMDRD945ML2144
iGMDRD541SNX-2112 (PF-04928473)1
iGMDRD341Triacsin c2
iGMDRD52Rotenone1
iGMDRD226ML0061
iGMDRD513BML-2591
iGMDRD524ISX-91
iGMDRD356PNU-746541
iGMDRD369TGX-1152
iGMDRD888Compound 442
iGMDRD74Idarubicin2
iGMDRD399Selumetinib6
iGMDRD188Piperlongumine3
iGMDRD483SCH-5290741
iGMDRD779PRL-3 Inhibitor I2
iGMDRD670ML 2101
iGMDRD546BMS-7548071
iGMDRD420Leucascandrolide A2
iGMDRD866BRD18121
iGMDRD126Tipifarnib4
iGMDRD394BX-7955
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside4
iGMDRD107Valdecoxib3
iGMDRD267Oligomycin A7
iGMDRD481Dactolisib2
iGMDRD82Quiflapon2
iGMDRD505Pevonedistat11
iGMDRD300Tozasertib9
iGMDRD269Purmorphamine1
iGMDRD872BRD71374
iGMDRD414MST-3122
iGMDRD345Compound 10b [PMID: 11504634]5
iGMDRD424Tamatinib4
iGMDRD116CD4372
iGMDRD607Ubistatin B3
iGMDRD512nutlin 33
iGMDRD84Lovastatin acid3
iGMDRD211(1S,3R)-RSL31
iGMDRD499PDMP3
iGMDRD57Chloropentafluorobenzene3
iGMDRD351GW843682X7
iGMDRD885Compound 1103
iGMDRD318PAC-13
iGMDRD782DC-45-A21
iGMDRD255SB2250023
iGMDRD8024-methylfasudil2
iGMDRD138PX 125
iGMDRD60Quinoclamine1
iGMDRD690PRIMA-1MET3
iGMDRD562Navitoclax2
iGMDRD144NSC953971
iGMDRD1008SR-II-138A1
iGMDRD359OSW-12
iGMDRD280CYTOCHALASIN B10
iGMDRD718Pyrvinium pamoate1
iGMDRD446LY 21832401

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAMTS20

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