ADAMTS20
Summary: The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase with thrombospondin type 1 motif 20 | MIM:611681 | Ensembl:ENSG00000173157 | HGNC:HGNC:17178 | PA134901626 | 12q12 |
GO terms in ADAMTS20
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006508 | proteolysis |
| BP | IEA | GO:0009967 | positive regulation of signal transduction |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0045636 | positive regulation of melanocyte differentiation |
| CC | IEA | GO:0005615 | extracellular space |
| CC | TAS | GO:0062023 | collagen-containing extracellular matrix |
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: ADAMTS20
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAMTS20
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5083635 | Defective B3GALTL causes Peters-plus syndrome (PpS) |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 7 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD367 | Ro 28-1675 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 6 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD541 | SNX-2112 (PF-04928473) | 1 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD226 | ML006 | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 6 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD866 | BRD1812 | 1 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD394 | BX-795 | 5 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD267 | Oligomycin A | 7 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD505 | Pevonedistat | 11 |
| iGMDRD300 | Tozasertib | 9 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD351 | GW843682X | 7 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD359 | OSW-1 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 10 |
| iGMDRD718 | Pyrvinium pamoate | 1 |
| iGMDRD446 | LY 2183240 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAMTS20
CLASSFICATION
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