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CDK12

Summary:

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
cyclin dependent kinase 12	MIM:615514	Ensembl:ENSG00000167258	HGNC:HGNC:24224	PA165431656	17q12

Gene Categories:

TUMOR SUPPRESSOR SERINE THREONINE KINASE TRANSCRIPTION FACTOR BINDING KINASE CLINICALLY ACTIONABLE DRUGGABLE GENOME

GO terms in CDK12

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
CC	IBA	GO:0000790	nuclear chromatin
CC	IDA	GO:0001650	fibrillar center
CC	IPI	GO:0002944	cyclin K-CDK12 complex
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IBA	GO:0005694	chromosome
CC	IBA	GO:0008024	cyclin/CDK positive transcription elongation factor complex
CC	IDA	GO:0016607	nuclear speck
CC	ISS	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex
BP	IBA	GO:0006368	transcription elongation from RNA polymerase II promoter
BP	IEA	GO:0006397	mRNA processing
BP	IBA	GO:0006468	protein phosphorylation
BP	ISS	GO:0008380	RNA splicing
BP	IBA	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
BP	IMP	GO:0043405	regulation of MAP kinase activity
BP	IEA	GO:0043484	regulation of RNA splicing
BP	IBA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IDA	GO:0046777	protein autophosphorylation
BP	IEA	GO:0051726	regulation of cell cycle
BP	IBA	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain
BP	IMP	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain
BP	IEA	GO:2000737	negative regulation of stem cell differentiation
MF	IDA	GO:0004672	protein kinase activity
MF	IBA	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0008134	transcription factor binding
MF	IBA	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
MF	IMP	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
MF	IEA	GO:0019901	protein kinase binding
MF	IBA	GO:0030332	cyclin binding
MF	IPI	GO:0030332	cyclin binding
MF	IBA	GO:0044212	transcription regulatory region DNA binding

Gene expression in normal tissue: CDK12

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDK12

Database	Pathway ID	Pathway Des.
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD74	Idarubicin	3
iGMDRD100	Zebularine	3
iGMDRD64	Parbendazole	2
iGMDRD451	Serdemetan	3
iGMDRD356	PNU-74654	2
iGMDRD474	Avrainvillamide	3
iGMDRD138	PX 12	3
iGMDRD513	BML-259	1
iGMDRD260	FQI-2	4
iGMDRD187	BRD9876	3
iGMDRD441	TW 37	2
iGMDRD326	Belinostat (PXD101)	1
iGMDRD446	LY 2183240	2
iGMDRD193	Fqi1	1
iGMDRD61	Kinetin riboside	1
iGMDRD466	Chaetocin	5
iGMDRD280	CYTOCHALASIN B	1
iGMDRD679	Bistramide A	2
iGMDRD433	Lexibulin	3
iGMDRD151	CHM-1	4
iGMDRD328	AR-42	1
iGMDRD971	PARP inhibitor	6
iGMDRD483	SCH-529074	3
iGMDRD871	BRD6368	1
iGMDRD329	Merck60	1
iGMDRD246	NPC26	3
iGMDRD137	Indisulam	5
iGMDRD121	GMX1778	3
iGMDRD202	Curcumin	2
iGMDRD103	SN-38	2
iGMDRD434	BMS-536924	1
iGMDRD289	Parthenolide	2
iGMDRD77	Itraconazole	3
iGMDRD351	GW843682X	2
iGMDRD123	Isoevodiamine	2
iGMDRD211	(1S,3R)-RSL3	3
iGMDRD945	ML214	3
iGMDRD512	nutlin 3	2
iGMDRD532	Olaparib	1
iGMDRD405	PIK-75	5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK12

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.