GO terms in CDK12


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIBAGO:0000790nuclear chromatin
CCIDAGO:0001650fibrillar center
CCIPIGO:0002944cyclin K-CDK12 complex
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005694chromosome
CCIBAGO:0008024cyclin/CDK positive transcription elongation factor complex
CCIDAGO:0016607nuclear speck
CCISSGO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex
BPIBAGO:0006368transcription elongation from RNA polymerase II promoter
BPIEAGO:0006397mRNA processing
BPIBAGO:0006468protein phosphorylation
BPISSGO:0008380RNA splicing
BPIBAGO:0032968positive regulation of transcription elongation from RNA polymerase II promoter
BPIMPGO:0043405regulation of MAP kinase activity
BPIEAGO:0043484regulation of RNA splicing
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0051726regulation of cell cycle
BPIBAGO:0070816phosphorylation of RNA polymerase II C-terminal domain
BPIMPGO:0070816phosphorylation of RNA polymerase II C-terminal domain
BPIEAGO:2000737negative regulation of stem cell differentiation
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008134transcription factor binding
MFIBAGO:0008353RNA polymerase II carboxy-terminal domain kinase activity
MFIMPGO:0008353RNA polymerase II carboxy-terminal domain kinase activity
MFIEAGO:0019901protein kinase binding
MFIBAGO:0030332cyclin binding
MFIPIGO:0030332cyclin binding
MFIBAGO:0044212transcription regulatory region DNA binding

Gene expression in normal tissue: CDK12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDK12


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair Genes
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD74Idarubicin3
iGMDRD100Zebularine3
iGMDRD64Parbendazole2
iGMDRD451Serdemetan3
iGMDRD356PNU-746542
iGMDRD474Avrainvillamide3
iGMDRD138PX 123
iGMDRD513BML-2591
iGMDRD260FQI-24
iGMDRD187BRD98763
iGMDRD441TW 372
iGMDRD326Belinostat (PXD101)1
iGMDRD446LY 21832402
iGMDRD193Fqi11
iGMDRD61Kinetin riboside1
iGMDRD466Chaetocin5
iGMDRD280CYTOCHALASIN B1
iGMDRD679Bistramide A2
iGMDRD433Lexibulin3
iGMDRD151CHM-14
iGMDRD328AR-421
iGMDRD971PARP inhibitor6
iGMDRD483SCH-5290743
iGMDRD871BRD63681
iGMDRD329Merck601
iGMDRD246NPC263
iGMDRD137Indisulam5
iGMDRD121GMX17783
iGMDRD202Curcumin2
iGMDRD103SN-382
iGMDRD434BMS-5369241
iGMDRD289Parthenolide2
iGMDRD77Itraconazole3
iGMDRD351GW843682X2
iGMDRD123Isoevodiamine2
iGMDRD211(1S,3R)-RSL33
iGMDRD945ML2143
iGMDRD512nutlin 32
iGMDRD532Olaparib1
iGMDRD405PIK-755

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK12

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