CDK12

Summary:

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecyclin dependent kinase 12
OMIM IDMIM:615514
Ensembl IDEnsembl:ENSG00000167258
HGNC IDHGNC:HGNC:24224
PHARMGKB IDPA165431656
Map Location17q12

GO terms in CDK12


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0000307 cyclin-dependent protein kinase holoenzyme complex
CC IBA GO:0000790 nuclear chromatin
CC IDA GO:0001650 fibrillar center
CC IPI GO:0002944 cyclin K-CDK12 complex
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
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Gene expression in normal tissue: CDK12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30Chromatin histone acetylation3Ferroptosis1Genome integrity1Cell cycle1Stilbenoid, diarylheptanoid and gingerol biosynthesis1p53 pathway1Apoptosis regulation1DNA replication1

Pathways in CDK12


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Database
Pathway ID
Pathway Des.
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-3700989 Transcriptional Regulation by TP53
reactome R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
reactome R-HSA-73857 RNA Polymerase II Transcription
reactome R-HSA-74160 Gene expression (Transcription)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD74 Idarubicin 3
iGMDRD100 Zebularine 3
iGMDRD64 Parbendazole 2
iGMDRD451 Serdemetan 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK12

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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