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iGMDRD326

Canonical SMILES: C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO

InChI: InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+

InChI Key: NCNRHFGMJRPRSK-MDZDMXLPSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Belinostat (PXD101)	CHEMBL408513	6918640	DB05015	Alone	Small Molecule

Drug Class:

Amides Amines Antineoplastic Agents Antineoplastic and Immunomodulating Agents Carboxylic Acids Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (weak)Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Histone Deacetylase Inhibitors Hydroxy Acids Hydroxylamines Immunosuppressive Agents Myelosuppressive Agents P-glycoprotein/ABCB1 Substrates Sulfones Sulfur Compounds

Drug Targets:

Drug Pathways:

Chromatin histone acetylation

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
8289	ARID1A	1
9757	KMT2B	1
55252	ASXL2	2
51755	CDK12	1
23019	CNOT1	1
5728	PTEN	1
171023	ASXL1	1
63967	CLSPN	2
54790	TET2	1

Gene in drug-gene network: Network Plot

Models in Belinostat (PXD101)

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