GO terms in CNOT1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000932P-body
CCIDAGO:0000932P-body
CCISSGO:0000932P-body
CCHDAGO:0005615extracellular space
CCIEAGO:0005634nucleus
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCHDAGO:0016020membrane
CCIDAGO:0030014CCR4-NOT complex
CCIBAGO:0030015CCR4-NOT core complex
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
BPTASGO:0000289nuclear-transcribed mRNA poly(A) tail shortening
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIEAGO:0007275multicellular organism development
BPIDAGO:0010606positive regulation of cytoplasmic mRNA processing body assembly
BPIBAGO:0017148negative regulation of translation
BPIDAGO:0017148negative regulation of translation
BPIDAGO:0033147negative regulation of intracellular estrogen receptor signaling pathway
BPIDAGO:0035195gene silencing by miRNA
BPIDAGO:0048387negative regulation of retinoic acid receptor signaling pathway
BPIDAGO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
BPIMPGO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
BPIMPGO:0061014positive regulation of mRNA catabolic process
BPIEAGO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic
BPIMPGO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
BPIBAGO:2000036regulation of stem cell population maintenance
BPIMPGO:2000036regulation of stem cell population maintenance
MFHDAGO:0003723RNA binding
MFIDAGO:0004535poly(A)-specific ribonuclease activity
MFIPIGO:0005515protein binding
MFIPIGO:0019904protein domain specific binding
MFIDAGO:0030331estrogen receptor binding
MFIBAGO:0032947protein-containing complex scaffold activity
MFIDAGO:0032947protein-containing complex scaffold activity
MFIDAGO:0042974retinoic acid receptor binding
MFIPIGO:0070016armadillo repeat domain binding

Gene expression in normal tissue: CNOT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CNOT1


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-429914Deadenylation-dependent mRNA decay
reactomeR-HSA-429947Deadenylation of mRNA
reactomeR-HSA-6791312TP53 Regulates Transcription of Cell Cycle Genes
reactomeR-HSA-6804115TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA
kegghsa03018RNA degradation - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD328AR-421
iGMDRD507GSK6906932
iGMDRD326Belinostat (PXD101)1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CNOT1

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