CLSPN
Summary: The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| claspin | MIM:605434 | Ensembl:ENSG00000092853 | HGNC:HGNC:19715 | PA134920757 | 1p34.3 |
GO terms in CLSPN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000077 | DNA damage checkpoint |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IDA | GO:0007095 | mitotic G2 DNA damage checkpoint |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0033314 | mitotic DNA replication checkpoint |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0010997 | anaphase-promoting complex binding |
Gene expression in normal tissue: CLSPN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CLSPN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atr_pathway | ATR signaling pathway |
| pid | plk1_pathway | PLK1 signaling events |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-75153 | Apoptotic execution phase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD326 | Belinostat (PXD101) | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD759 | PFI-1 | 1 |
| iGMDRD776 | QL-XI-92 | 1 |
| iGMDRD328 | AR-42 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLSPN
CLASSFICATION
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