TET2

Summary: The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametet methylcytosine dioxygenase 2
OMIM IDMIM:612839
Ensembl IDEnsembl:ENSG00000168769
HGNC IDHGNC:HGNC:25941
PHARMGKB IDPA162405634
Map Location4q24

GO terms in TET2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
BP IBA GO:0006211 5-methylcytosine catabolic process
BP IDA GO:0006211 5-methylcytosine catabolic process
BP IDA GO:0006493 protein O-linked glycosylation
BP IMP GO:0006493 protein O-linked glycosylation
BP IEA GO:0007049 cell cycle
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Gene expression in normal tissue: TET2

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 47undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 43BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 13

Gene-drug pathway distribution

undefined23PI3K/MTOR signaling4RTK signaling3Genome integrity3Mitosis2Other, kinases2Chromatin histone acetylation2Cell cycle2Protein stability and degradation1Chromatin other1

Pathways in TET2


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Database
Pathway ID
Pathway Des.
wikipathways WP3584 MECP2 and Associated Rett Syndrome
reactome R-HSA-212165 Epigenetic regulation of gene expression
reactome R-HSA-5221030 TET1,2,3 and TDG demethylate DNA
reactome R-HSA-74160 Gene expression (Transcription)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD61 Kinetin riboside 2
iGMDRD163 all trans Retinoic Acid 1
iGMDRD107 Valdecoxib 3
iGMDRD326 Belinostat (PXD101) 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TET2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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