TET2
Summary: The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tet methylcytosine dioxygenase 2 | MIM:612839 | Ensembl:ENSG00000168769 | HGNC:HGNC:25941 | PA162405634 | 4q24 |
GO terms in TET2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| BP | IBA | GO:0006211 | 5-methylcytosine catabolic process |
| BP | IDA | GO:0006211 | 5-methylcytosine catabolic process |
| BP | IDA | GO:0006493 | protein O-linked glycosylation |
| BP | IMP | GO:0006493 | protein O-linked glycosylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IBA | GO:0030099 | myeloid cell differentiation |
| BP | IMP | GO:0030099 | myeloid cell differentiation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IBA | GO:0070989 | oxidative demethylation |
| BP | IBA | GO:0080111 | DNA demethylation |
| BP | IDA | GO:0080111 | DNA demethylation |
| BP | IMP | GO:0080182 | histone H3-K4 trimethylation |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0005506 | iron ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008198 | ferrous iron binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0070579 | methylcytosine dioxygenase activity |
| MF | IDA | GO:0070579 | methylcytosine dioxygenase activity |
| MF | IMP | GO:0070579 | methylcytosine dioxygenase activity |
| MF | ISS | GO:0070579 | methylcytosine dioxygenase activity |
Gene expression in normal tissue: TET2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TET2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD163 | all trans Retinoic Acid | 1 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD326 | Belinostat (PXD101) | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD1032 | VNLG/124 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD198 | AC1LE7KD | 1 |
| iGMDRD348 | BMS-345541 | 1 |
| iGMDRD654 | SL 0101-1 | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD571 | Cabozantinib | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD1034 | WZ3105 | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD97 | Bexarotene | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD632 | CP466722 | 1 |
| iGMDRD781 | Sirolimus | 8 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD453 | GW2580 | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD369 | TGX-115 | 6 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD585 | MPS1-IN-1 | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD870 | BRD63610 | 6 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD463 | ZSTK 474 | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD276 | AS 605240 | 1 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD300 | Tozasertib | 8 |
| iGMDRD1016 | THZ-2-49 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD6 | AM-580 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TET2
CLASSFICATION
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