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iGMDRD571

Canonical SMILES: COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F

InChI: InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)

InChI Key: ONIQOQHATWINJY-UHFFFAOYSA-N

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Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Standard NameCabozantinib CHEMBLCHEMBL2105717 CHEMBL2103868 Pubchem CID25102800 DRUGBANK IDDB08875 Drug StatusAlone Drug TypeSmall Molecule

Drug Class:

Amides Antineoplastic Agents Antineoplastic and Immunomodulating Agents Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Kinase Inhibitor Protein Kinase Inhibitors Receptor Protein-Tyrosine Kinases, antagonists & inhibitors Vascular Endothelial Growth Factor Receptor 2 Antagonist

Drug Targets:

VEGFR MET (P08581)KDR (P35968)RET (P07949)KIT FLT1 FLT3 FLT4 Tie2 AXL

Drug Pathways:

Other, kinases

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

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Gene ID	Gene Name	Model Num.
55252	ASXL2	1
7158	TP53BP1	1
7307	U2AF1	2
6098	ROS1	5

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Gene in drug-gene network: Network Plot

Models in Cabozantinib

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.