PTPN11
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, non-receptor type 11 | MIM:176876 | Ensembl:ENSG00000179295 | HGNC:HGNC:9644 | PA33986 | 12q24.13 |
GO terms in PTPN11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0001784 | phosphotyrosine residue binding |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | IDA | GO:0004721 | phosphoprotein phosphatase activity |
| MF | EXP | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IMP | GO:0004725 | protein tyrosine phosphatase activity |
| MF | TAS | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IMP | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| MF | TAS | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| MF | IPI | GO:0005070 | SH3/SH2 adaptor activity |
| MF | IPI | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0030971 | receptor tyrosine kinase binding |
| MF | IEA | GO:0031748 | D1 dopamine receptor binding |
| MF | IEA | GO:0043274 | phospholipase binding |
| MF | IEA | GO:0043560 | insulin receptor substrate binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IEA | GO:0050839 | cell adhesion molecule binding |
| MF | IEA | GO:0051428 | peptide hormone receptor binding |
| BP | IEA | GO:0000077 | DNA damage checkpoint |
| BP | IEA | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0006641 | triglyceride metabolic process |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IMP | GO:0007420 | brain development |
| BP | IMP | GO:0007507 | heart development |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0009755 | hormone-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0021697 | cerebellar cortex formation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0030220 | platelet formation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IEA | GO:0032528 | microvillus organization |
| BP | IEA | GO:0033277 | abortive mitotic cell cycle |
| BP | IMP | GO:0033628 | regulation of cell adhesion mediated by integrin |
| BP | IEA | GO:0033629 | negative regulation of cell adhesion mediated by integrin |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0035265 | organ growth |
| BP | IDA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IMP | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IEA | GO:0035855 | megakaryocyte development |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IMP | GO:0036302 | atrioventricular canal development |
| BP | IDA | GO:0038127 | ERBB signaling pathway |
| BP | IEA | GO:0040014 | regulation of multicellular organism growth |
| BP | IEA | GO:0042445 | hormone metabolic process |
| BP | IEA | GO:0042593 | glucose homeostasis |
| BP | IDA | GO:0043254 | regulation of protein complex assembly |
| BP | IEA | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IEA | GO:0046676 | negative regulation of insulin secretion |
| BP | IEA | GO:0046825 | regulation of protein export from nucleus |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0046887 | positive regulation of hormone secretion |
| BP | IEA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IEA | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | IDA | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0048609 | multicellular organismal reproductive process |
| BP | IMP | GO:0048806 | genitalia development |
| BP | IMP | GO:0048839 | inner ear development |
| BP | IEA | GO:0048873 | homeostasis of number of cells within a tissue |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0051463 | negative regulation of cortisol secretion |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0060020 | Bergmann glial cell differentiation |
| BP | IEA | GO:0060125 | negative regulation of growth hormone secretion |
| BP | IMP | GO:0060325 | face morphogenesis |
| BP | TAS | GO:0060338 | regulation of type I interferon-mediated signaling pathway |
| BP | IEA | GO:0061582 | intestinal epithelial cell migration |
| BP | TAS | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071260 | cellular response to mechanical stimulus |
| BP | TAS | GO:0071345 | cellular response to cytokine stimulus |
| BP | IMP | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IDA | GO:2001275 | positive regulation of glucose import in response to insulin stimulus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | IMP | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: PTPN11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPN11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-112411 | MAPK1 (ERK2) activation |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1170546 | Prolactin receptor signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1295596 | Spry regulation of FGF signaling |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-180292 | GAB1 signalosome |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210990 | PECAM1 interactions |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2586552 | Signaling by Leptin |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389513 | CTLA4 inhibitory signaling |
| reactome | R-HSA-389948 | PD-1 signaling |
| reactome | R-HSA-391160 | Signal regulatory protein family interactions |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418886 | Netrin mediated repulsion signals |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-432142 | Platelet sensitization by LDL |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654689 | PI-3K cascade:FGFR1 |
| reactome | R-HSA-5654693 | FRS-mediated FGFR1 signaling |
| reactome | R-HSA-5654695 | PI-3K cascade:FGFR2 |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654700 | FRS-mediated FGFR2 signaling |
| reactome | R-HSA-5654706 | FRS-mediated FGFR3 signaling |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654710 | PI-3K cascade:FGFR3 |
| reactome | R-HSA-5654712 | FRS-mediated FGFR4 signaling |
| reactome | R-HSA-5654716 | Downstream signaling of activated FGFR4 |
| reactome | R-HSA-5654720 | PI-3K cascade:FGFR4 |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-8854691 | Interleukin-20 family signaling |
| reactome | R-HSA-8865999 | MET activates PTPN11 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8934593 | Regulation of RUNX1 Expression and Activity |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9008059 | Interleukin-37 signaling |
| reactome | R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-936964 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| biocarta | cell2cellpathway | cell to cell adhesion signaling |
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | il6pathway | il 6 signaling pathway |
| biocarta | insulinpathway | insulin signaling pathway |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epopathway | EPO signaling pathway |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | ifngpathway | IFN-gamma pathway |
| pid | igf1_pathway | IGF1 pathway |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | il5_pathway | IL5-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | insulin_pathway | Insulin Pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2253 | Pilocytic astrocytoma |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD1002 | rTRAIL | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD689 | EX-8678 | 1 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD150 | RITA | 4 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD571 | Cabozantinib | 1 |
| iGMDRD646 | PHA-793887 | 1 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD505 | Pevonedistat | 7 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD780 | PP-30 | 8 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD44 | Temozolomide | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD491 | TAE-684 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPN11
CLASSFICATION
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