PTPN11
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:176876 Ensembl IDEnsembl:ENSG00000179295 HGNC IDHGNC:HGNC:9644 PHARMGKB IDPA33986 Map Location12q24.13 | |||||
GO terms in PTPN11
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0001784 | phosphotyrosine residue binding |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | IDA | GO:0004721 | phosphoprotein phosphatase activity |
| MF | EXP | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IMP | GO:0004725 | protein tyrosine phosphatase activity |
Gene expression in normal tissue: PTPN11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPN11
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPN11
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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