iGMDRD689

Canonical SMILES: COC1=NC=CC(=C1NS(=O)(=O)C2=C(C=C(C=C2)F)F)C3=CC4=C(C=CN=C4C=C3)C5=CN=NC=C5

InChI: InChI=1S/C25H17F2N5O3S/c1-35-25-24(32-36(33,34)23-5-3-17(26)13-21(23)27)19(8-10-29-25)15-2-4-22-20(12-15)18(7-9-28-22)16-6-11-30-31-14-16/h2-14,32H,1H3

InChI Key: NPPBBAURRJGWEH-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameEX-8678
Pubchem CID52914900
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

PI3KMTOR

Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophageal Adenocarcinoma (ESCA) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1

Drug-gene pathway enrichments

10reactome: Signal Transduction6reactome: Signaling by Receptor Tyrosine Kinases6reactome: Developmental Biology5reactome: Disease5reactome: Immune System4reactome: Axon guidance4reactome: Diseases of signal transduction4reactome: Gene expression (Transcription)4reactome: Innate Immune System4reactome: Signaling by ERBB2

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7514 XPO1 1
55252 ASXL2 1
2033 EP300 1
2064 ERBB2 1
Showing 1 to 4 of 7 rows

Gene in drug-gene network: Network Plot

Models in EX-8678

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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