IL1B
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 beta | MIM:147720 | Ensembl:ENSG00000125538 | HGNC:HGNC:5992 | PA29808 | 2q14.1 |
GO terms in IL1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005576 | extracellular region |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IMP | GO:0005615 | extracellular space |
| CC | IEA | GO:0005764 | lysosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0030141 | secretory granule |
| CC | IEA | GO:0030141 | secretory granule |
| CC | IEA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IMP | GO:0000165 | MAPK cascade |
| BP | IBA | GO:0000187 | activation of MAPK activity |
| BP | IDA | GO:0000187 | activation of MAPK activity |
| BP | IBA | GO:0001660 | fever generation |
| BP | IBA | GO:0001666 | response to hypoxia |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | NAS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IBA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | IBA | GO:0002439 | chronic inflammatory response to antigenic stimulus |
| BP | IC | GO:0002711 | positive regulation of T cell mediated immunity |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006954 | inflammatory response |
| BP | NAS | GO:0006954 | inflammatory response |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007566 | embryo implantation |
| BP | IBA | GO:0007613 | memory |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0009408 | response to heat |
| BP | IEA | GO:0009743 | response to carbohydrate |
| BP | IBA | GO:0010193 | response to ozone |
| BP | IBA | GO:0010332 | response to gamma radiation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IBA | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | IDA | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | ISS | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IBA | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IDA | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IBA | GO:0010829 | negative regulation of glucose transmembrane transport |
| BP | ISS | GO:0010829 | negative regulation of glucose transmembrane transport |
| BP | IBA | GO:0014050 | negative regulation of glutamate secretion |
| BP | IBA | GO:0014070 | response to organic cyclic compound |
| BP | NAS | GO:0014805 | smooth muscle adaptation |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IDA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0030213 | hyaluronan biosynthetic process |
| BP | IDA | GO:0030213 | hyaluronan biosynthetic process |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | IEA | GO:0030593 | neutrophil chemotaxis |
| BP | IBA | GO:0030728 | ovulation |
| BP | IBA | GO:0030730 | sequestering of triglyceride |
| BP | IDA | GO:0030730 | sequestering of triglyceride |
| BP | IC | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | IBA | GO:0031622 | positive regulation of fever generation |
| BP | ISS | GO:0031622 | positive regulation of fever generation |
| BP | IBA | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IDA | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IBA | GO:0032308 | positive regulation of prostaglandin secretion |
| BP | ISS | GO:0032308 | positive regulation of prostaglandin secretion |
| BP | IBA | GO:0032355 | response to estradiol |
| BP | IBA | GO:0032611 | interleukin-1 beta production |
| BP | IEA | GO:0032611 | interleukin-1 beta production |
| BP | IBA | GO:0032635 | interleukin-6 production |
| BP | IEA | GO:0032635 | interleukin-6 production |
| BP | IDA | GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production |
| BP | IBA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | IDA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | IBA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | TAS | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IDA | GO:0032757 | positive regulation of interleukin-8 production |
| BP | IBA | GO:0033092 | positive regulation of immature T cell proliferation in thymus |
| BP | NAS | GO:0033129 | positive regulation of histone phosphorylation |
| BP | IEA | GO:0033198 | response to ATP |
| BP | IBA | GO:0033280 | response to vitamin D |
| BP | IBA | GO:0033591 | response to L-ascorbic acid |
| BP | IBA | GO:0034116 | positive regulation of heterotypic cell-cell adhesion |
| BP | IDA | GO:0034116 | positive regulation of heterotypic cell-cell adhesion |
| BP | NAS | GO:0034116 | positive regulation of heterotypic cell-cell adhesion |
| BP | NAS | GO:0035066 | positive regulation of histone acetylation |
| BP | IBA | GO:0035176 | social behavior |
| BP | IBA | GO:0035234 | ectopic germ cell programmed cell death |
| BP | IEA | GO:0035234 | ectopic germ cell programmed cell death |
| BP | IBA | GO:0035505 | positive regulation of myosin light chain kinase activity |
| BP | IDA | GO:0035505 | positive regulation of myosin light chain kinase activity |
| BP | IBA | GO:0035634 | response to stilbenoid |
| BP | IBA | GO:0035690 | cellular response to drug |
| BP | IDA | GO:0035690 | cellular response to drug |
| BP | IBA | GO:0035902 | response to immobilization stress |
| BP | IBA | GO:0042060 | wound healing |
| BP | IDA | GO:0042102 | positive regulation of T cell proliferation |
| BP | IBA | GO:0042493 | response to drug |
| BP | IDA | GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0043278 | response to morphine |
| BP | IBA | GO:0043407 | negative regulation of MAP kinase activity |
| BP | ISS | GO:0043407 | negative regulation of MAP kinase activity |
| BP | IBA | GO:0043434 | response to peptide hormone |
| BP | IBA | GO:0043491 | protein kinase B signaling |
| BP | IMP | GO:0043491 | protein kinase B signaling |
| BP | IBA | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IBA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IBA | GO:0045080 | positive regulation of chemokine biosynthetic process |
| BP | IEA | GO:0045080 | positive regulation of chemokine biosynthetic process |
| BP | IBA | GO:0045086 | positive regulation of interleukin-2 biosynthetic process |
| BP | IMP | GO:0045086 | positive regulation of interleukin-2 biosynthetic process |
| BP | IBA | GO:0045410 | positive regulation of interleukin-6 biosynthetic process |
| BP | IEA | GO:0045410 | positive regulation of interleukin-6 biosynthetic process |
| BP | IBA | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | IDA | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | IBA | GO:0045471 | response to ethanol |
| BP | IBA | GO:0045665 | negative regulation of neuron differentiation |
| BP | IBA | GO:0045687 | positive regulation of glial cell differentiation |
| BP | IBA | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | ISS | GO:0045766 | positive regulation of angiogenesis |
| BP | IBA | GO:0045833 | negative regulation of lipid metabolic process |
| BP | ISS | GO:0045833 | negative regulation of lipid metabolic process |
| BP | IBA | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IMP | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0046330 | positive regulation of JNK cascade |
| BP | ISS | GO:0046330 | positive regulation of JNK cascade |
| BP | IBA | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | ISS | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | NAS | GO:0046827 | positive regulation of protein export from nucleus |
| BP | IBA | GO:0048711 | positive regulation of astrocyte differentiation |
| BP | IBA | GO:0050691 | regulation of defense response to virus by host |
| BP | IEA | GO:0050691 | regulation of defense response to virus by host |
| BP | IBA | GO:0050766 | positive regulation of phagocytosis |
| BP | IMP | GO:0050766 | positive regulation of phagocytosis |
| BP | IBA | GO:0050796 | regulation of insulin secretion |
| BP | IDA | GO:0050796 | regulation of insulin secretion |
| BP | IBA | GO:0050805 | negative regulation of synaptic transmission |
| BP | ISS | GO:0050805 | negative regulation of synaptic transmission |
| BP | IBA | GO:0050995 | negative regulation of lipid catabolic process |
| BP | IDA | GO:0050995 | negative regulation of lipid catabolic process |
| BP | IBA | GO:0050996 | positive regulation of lipid catabolic process |
| BP | ISS | GO:0050996 | positive regulation of lipid catabolic process |
| BP | IBA | GO:0050999 | regulation of nitric-oxide synthase activity |
| BP | IDA | GO:0050999 | regulation of nitric-oxide synthase activity |
| BP | IBA | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| BP | IDA | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IBA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IBA | GO:0051384 | response to glucocorticoid |
| BP | IEA | GO:0051781 | positive regulation of cell division |
| BP | NAS | GO:0060355 | positive regulation of cell adhesion molecule production |
| BP | IBA | GO:0060559 | positive regulation of calcidiol 1-monooxygenase activity |
| BP | IDA | GO:0060559 | positive regulation of calcidiol 1-monooxygenase activity |
| BP | IBA | GO:0070164 | negative regulation of adiponectin secretion |
| BP | ISS | GO:0070164 | negative regulation of adiponectin secretion |
| BP | IDA | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0070487 | monocyte aggregation |
| BP | IDA | GO:0070487 | monocyte aggregation |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IBA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IBA | GO:0071236 | cellular response to antibiotic |
| BP | IBA | GO:0071260 | cellular response to mechanical stimulus |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IDA | GO:0071310 | cellular response to organic substance |
| BP | IBA | GO:0071333 | cellular response to glucose stimulus |
| BP | IBA | GO:0071398 | cellular response to fatty acid |
| BP | IBA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IDA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IBA | GO:0071548 | response to dexamethasone |
| BP | IBA | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production |
| BP | IDA | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production |
| BP | IBA | GO:0090023 | positive regulation of neutrophil chemotaxis |
| BP | IBA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IBA | GO:1900745 | positive regulation of p38MAPK cascade |
| BP | ISS | GO:1900745 | positive regulation of p38MAPK cascade |
| BP | IDA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IBA | GO:1903140 | regulation of establishment of endothelial barrier |
| BP | IDA | GO:1903140 | regulation of establishment of endothelial barrier |
| BP | IBA | GO:2000173 | negative regulation of branching morphogenesis of a nerve |
| BP | IBA | GO:2000178 | negative regulation of neural precursor cell proliferation |
| BP | IDA | GO:2000556 | positive regulation of T-helper 1 cell cytokine production |
| BP | IBA | GO:2000778 | positive regulation of interleukin-6 secretion |
| BP | IEA | GO:2000778 | positive regulation of interleukin-6 secretion |
| BP | IBA | GO:2000866 | positive regulation of estradiol secretion |
| BP | IDA | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | IMP | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005149 | interleukin-1 receptor binding |
| MF | NAS | GO:0005149 | interleukin-1 receptor binding |
| MF | IDA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
Gene expression in normal tissue: IL1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448706 | Interleukin-1 processing |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5660668 | CLEC7A/inflammasome pathway |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1455 | Serotonin Transporter Activity |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3354 | C-type lectin receptors (CLRs) |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3890 | Nanomaterial induced inflammasome activation |
| wikipathways | WP3893 | Development and heterogeneity of the ILC family |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP530 | Cytokines and Inflammatory Response |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP727 | Monoamine Transport |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| netpath | Pathway_IL1 | IL1 |
| pid | anthraxpathway | Cellular roles of Anthrax toxin |
| pid | ifngpathway | IFN-gamma pathway |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il1pathway | IL1-mediated signaling events |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il27pathway | IL27-mediated signaling events |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| kegg | hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD655 | SCHEMBL618594 | 1 |
| iGMDRD660 | GSK-1070916 | 1 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD402 | AKT Inhibitor VIII | 1 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD264 | Bryostatin 1 | 1 |
| iGMDRD556 | Quizartinib | 1 |
| iGMDRD935 | JQ12 | 1 |
| iGMDRD552 | AZD-1775 | 5 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD755 | XMD13-2 | 1 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD435 | BI-2536 | 5 |
| iGMDRD1002 | rTRAIL | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD292 | NSC87877 | 1 |
| iGMDRD689 | EX-8678 | 1 |
| iGMDRD376 | Tivozanib | 1 |
| iGMDRD593 | CX-5461 | 1 |
| iGMDRD759 | PFI-1 | 1 |
| iGMDRD758 | JW-7-24-1 | 1 |
| iGMDRD507 | GSK690693 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD332 | A-770041 | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD654 | SL 0101-1 | 1 |
| iGMDRD749 | ZINC6718453 | 1 |
| iGMDRD659 | Avagacestat (BMS-708163) | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD443 | Linifanib | 1 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD130 | Enzastaurin | 1 |
| iGMDRD776 | QL-XI-92 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD673 | LSM-1215 | 1 |
| iGMDRD348 | BMS-345541 | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD608 | Refametinib | 3 |
| iGMDRD446 | LY 2183240 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL1B
CLASSFICATION
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