IL1B


Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interleukin 1 betaMIM:147720Ensembl:ENSG00000125538HGNC:HGNC:5992PA298082q14.1

GO terms in IL1B


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005576extracellular region
CCNASGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIMPGO:0005615extracellular space
CCIEAGO:0005764lysosome
CCTASGO:0005829cytosol
CCIBAGO:0030141secretory granule
CCIEAGO:0030141secretory granule
CCIEAGO:0070062extracellular exosome
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0000165MAPK cascade
BPIMPGO:0000165MAPK cascade
BPIBAGO:0000187activation of MAPK activity
BPIDAGO:0000187activation of MAPK activity
BPIBAGO:0001660fever generation
BPIBAGO:0001666response to hypoxia
BPIDAGO:0001934positive regulation of protein phosphorylation
BPNASGO:0001934positive regulation of protein phosphorylation
BPIBAGO:0002437inflammatory response to antigenic stimulus
BPIBAGO:0002439chronic inflammatory response to antigenic stimulus
BPICGO:0002711positive regulation of T cell mediated immunity
BPTASGO:0006915apoptotic process
BPIDAGO:0006954inflammatory response
BPNASGO:0006954inflammatory response
BPIEAGO:0006955immune response
BPTASGO:0007165signal transduction
BPIBAGO:0007204positive regulation of cytosolic calcium ion concentration
BPTASGO:0007267cell-cell signaling
BPTASGO:0007566embryo implantation
BPIBAGO:0007613memory
BPIDAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008285negative regulation of cell proliferation
BPIBAGO:0009408response to heat
BPIEAGO:0009743response to carbohydrate
BPIBAGO:0010193response to ozone
BPIBAGO:0010332response to gamma radiation
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0010575positive regulation of vascular endothelial growth factor production
BPIDAGO:0010575positive regulation of vascular endothelial growth factor production
BPISSGO:0010575positive regulation of vascular endothelial growth factor production
BPIDAGO:0010628positive regulation of gene expression
BPIBAGO:0010718positive regulation of epithelial to mesenchymal transition
BPIDAGO:0010718positive regulation of epithelial to mesenchymal transition
BPIBAGO:0010829negative regulation of glucose transmembrane transport
BPISSGO:0010829negative regulation of glucose transmembrane transport
BPIBAGO:0014050negative regulation of glutamate secretion
BPIBAGO:0014070response to organic cyclic compound
BPNASGO:0014805smooth muscle adaptation
BPIBAGO:0019221cytokine-mediated signaling pathway
BPIDAGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0030213hyaluronan biosynthetic process
BPIDAGO:0030213hyaluronan biosynthetic process
BPIDAGO:0030335positive regulation of cell migration
BPIBAGO:0030593neutrophil chemotaxis
BPIEAGO:0030593neutrophil chemotaxis
BPIBAGO:0030728ovulation
BPIBAGO:0030730sequestering of triglyceride
BPIDAGO:0030730sequestering of triglyceride
BPICGO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway
BPIBAGO:0031622positive regulation of fever generation
BPISSGO:0031622positive regulation of fever generation
BPIBAGO:0031663lipopolysaccharide-mediated signaling pathway
BPIDAGO:0031663lipopolysaccharide-mediated signaling pathway
BPIBAGO:0032308positive regulation of prostaglandin secretion
BPISSGO:0032308positive regulation of prostaglandin secretion
BPIBAGO:0032355response to estradiol
BPIBAGO:0032611interleukin-1 beta production
BPIEAGO:0032611interleukin-1 beta production
BPIBAGO:0032635interleukin-6 production
BPIEAGO:0032635interleukin-6 production
BPIDAGO:0032725positive regulation of granulocyte macrophage colony-stimulating factor production
BPIBAGO:0032729positive regulation of interferon-gamma production
BPIDAGO:0032729positive regulation of interferon-gamma production
BPIBAGO:0032755positive regulation of interleukin-6 production
BPTASGO:0032755positive regulation of interleukin-6 production
BPIDAGO:0032757positive regulation of interleukin-8 production
BPIBAGO:0033092positive regulation of immature T cell proliferation in thymus
BPNASGO:0033129positive regulation of histone phosphorylation
BPIEAGO:0033198response to ATP
BPIBAGO:0033280response to vitamin D
BPIBAGO:0033591response to L-ascorbic acid
BPIBAGO:0034116positive regulation of heterotypic cell-cell adhesion
BPIDAGO:0034116positive regulation of heterotypic cell-cell adhesion
BPNASGO:0034116positive regulation of heterotypic cell-cell adhesion
BPNASGO:0035066positive regulation of histone acetylation
BPIBAGO:0035176social behavior
BPIBAGO:0035234ectopic germ cell programmed cell death
BPIEAGO:0035234ectopic germ cell programmed cell death
BPIBAGO:0035505positive regulation of myosin light chain kinase activity
BPIDAGO:0035505positive regulation of myosin light chain kinase activity
BPIBAGO:0035634response to stilbenoid
BPIBAGO:0035690cellular response to drug
BPIDAGO:0035690cellular response to drug
BPIBAGO:0035902response to immobilization stress
BPIBAGO:0042060wound healing
BPIDAGO:0042102positive regulation of T cell proliferation
BPIBAGO:0042493response to drug
BPIDAGO:0043122regulation of I-kappaB kinase/NF-kappaB signaling
BPIBAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIBAGO:0043278response to morphine
BPIBAGO:0043407negative regulation of MAP kinase activity
BPISSGO:0043407negative regulation of MAP kinase activity
BPIBAGO:0043434response to peptide hormone
BPIBAGO:0043491protein kinase B signaling
BPIMPGO:0043491protein kinase B signaling
BPIBAGO:0043507positive regulation of JUN kinase activity
BPIBAGO:0043525positive regulation of neuron apoptotic process
BPIBAGO:0045080positive regulation of chemokine biosynthetic process
BPIEAGO:0045080positive regulation of chemokine biosynthetic process
BPIBAGO:0045086positive regulation of interleukin-2 biosynthetic process
BPIMPGO:0045086positive regulation of interleukin-2 biosynthetic process
BPIBAGO:0045410positive regulation of interleukin-6 biosynthetic process
BPIEAGO:0045410positive regulation of interleukin-6 biosynthetic process
BPIBAGO:0045429positive regulation of nitric oxide biosynthetic process
BPIDAGO:0045429positive regulation of nitric oxide biosynthetic process
BPIBAGO:0045471response to ethanol
BPIBAGO:0045665negative regulation of neuron differentiation
BPIBAGO:0045687positive regulation of glial cell differentiation
BPIBAGO:0045766positive regulation of angiogenesis
BPIDAGO:0045766positive regulation of angiogenesis
BPISSGO:0045766positive regulation of angiogenesis
BPIBAGO:0045833negative regulation of lipid metabolic process
BPISSGO:0045833negative regulation of lipid metabolic process
BPIBAGO:0045840positive regulation of mitotic nuclear division
BPIMPGO:0045840positive regulation of mitotic nuclear division
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0046330positive regulation of JNK cascade
BPISSGO:0046330positive regulation of JNK cascade
BPIBAGO:0046627negative regulation of insulin receptor signaling pathway
BPISSGO:0046627negative regulation of insulin receptor signaling pathway
BPNASGO:0046827positive regulation of protein export from nucleus
BPIBAGO:0048711positive regulation of astrocyte differentiation
BPIBAGO:0050691regulation of defense response to virus by host
BPIEAGO:0050691regulation of defense response to virus by host
BPIBAGO:0050766positive regulation of phagocytosis
BPIMPGO:0050766positive regulation of phagocytosis
BPIBAGO:0050796regulation of insulin secretion
BPIDAGO:0050796regulation of insulin secretion
BPIBAGO:0050805negative regulation of synaptic transmission
BPISSGO:0050805negative regulation of synaptic transmission
BPIBAGO:0050995negative regulation of lipid catabolic process
BPIDAGO:0050995negative regulation of lipid catabolic process
BPIBAGO:0050996positive regulation of lipid catabolic process
BPISSGO:0050996positive regulation of lipid catabolic process
BPIBAGO:0050999regulation of nitric-oxide synthase activity
BPIDAGO:0050999regulation of nitric-oxide synthase activity
BPIBAGO:0051044positive regulation of membrane protein ectodomain proteolysis
BPIDAGO:0051044positive regulation of membrane protein ectodomain proteolysis
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIBAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIBAGO:0051384response to glucocorticoid
BPIEAGO:0051781positive regulation of cell division
BPNASGO:0060355positive regulation of cell adhesion molecule production
BPIBAGO:0060559positive regulation of calcidiol 1-monooxygenase activity
BPIDAGO:0060559positive regulation of calcidiol 1-monooxygenase activity
BPIBAGO:0070164negative regulation of adiponectin secretion
BPISSGO:0070164negative regulation of adiponectin secretion
BPIDAGO:0070372regulation of ERK1 and ERK2 cascade
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIBAGO:0070487monocyte aggregation
BPIDAGO:0070487monocyte aggregation
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIBAGO:0071222cellular response to lipopolysaccharide
BPIBAGO:0071236cellular response to antibiotic
BPIBAGO:0071260cellular response to mechanical stimulus
BPIEPGO:0071260cellular response to mechanical stimulus
BPIDAGO:0071310cellular response to organic substance
BPIBAGO:0071333cellular response to glucose stimulus
BPIBAGO:0071398cellular response to fatty acid
BPIBAGO:0071407cellular response to organic cyclic compound
BPIDAGO:0071407cellular response to organic cyclic compound
BPIBAGO:0071548response to dexamethasone
BPIBAGO:0071639positive regulation of monocyte chemotactic protein-1 production
BPIDAGO:0071639positive regulation of monocyte chemotactic protein-1 production
BPIBAGO:0090023positive regulation of neutrophil chemotaxis
BPIBAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIBAGO:1900745positive regulation of p38MAPK cascade
BPISSGO:1900745positive regulation of p38MAPK cascade
BPIDAGO:1901224positive regulation of NIK/NF-kappaB signaling
BPIBAGO:1903140regulation of establishment of endothelial barrier
BPIDAGO:1903140regulation of establishment of endothelial barrier
BPIBAGO:2000173negative regulation of branching morphogenesis of a nerve
BPIBAGO:2000178negative regulation of neural precursor cell proliferation
BPIDAGO:2000556positive regulation of T-helper 1 cell cytokine production
BPIBAGO:2000778positive regulation of interleukin-6 secretion
BPIEAGO:2000778positive regulation of interleukin-6 secretion
BPIBAGO:2000866positive regulation of estradiol secretion
BPIDAGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
MFIBAGO:0005125cytokine activity
MFIDAGO:0005125cytokine activity
MFIMPGO:0005125cytokine activity
MFIBAGO:0005149interleukin-1 receptor binding
MFNASGO:0005149interleukin-1 receptor binding
MFIDAGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFIPIGO:0019904protein domain specific binding

Gene expression in normal tissue: IL1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL1B


DatabasePathway IDPathway Des.
biocartail1rpathwaysignal transduction through il1r
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448706Interleukin-1 processing
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5660668CLEC7A/inflammasome pathway
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-9020702Interleukin-1 signaling
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1455Serotonin Transporter Activity
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP1533Vitamin B12 Metabolism
wikipathwaysWP176Folate Metabolism
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
wikipathwaysWP2865IL1 and megakaryocytes in obesity
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3354C-type lectin receptors (CLRs)
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3890Nanomaterial induced inflammasome activation
wikipathwaysWP3893Development and heterogeneity of the ILC family
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP530Cytokines and Inflammatory Response
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP619Type II interferon signaling (IFNG)
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
wikipathwaysWP727Monoamine Transport
wikipathwaysWP75Toll-like Receptor Signaling Pathway
netpathPathway_IL1IL1
pidanthraxpathwayCellular roles of Anthrax toxin
pidifngpathwayIFN-gamma pathway
pidil12_2pathwayIL12-mediated signaling events
pidil1pathwayIL1-mediated signaling events
pidil23pathwayIL23-mediated signaling events
pidil27pathwayIL27-mediated signaling events
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05134Legionellosis - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05332Graft-versus-host disease - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD551Ponatinib1
iGMDRD459RO-33061
iGMDRD655SCHEMBL6185941
iGMDRD660GSK-10709161
iGMDRD221Tamoxifen1
iGMDRD5Tyrphostin AG 14782
iGMDRD402AKT Inhibitor VIII1
iGMDRD202Curcumin6
iGMDRD293Bleomycin1
iGMDRD353PD03259012
iGMDRD264Bryostatin 11
iGMDRD556Quizartinib1
iGMDRD935JQ121
iGMDRD552AZD-17755
iGMDRD886Compound 1541A1
iGMDRD505Pevonedistat4
iGMDRD755XMD13-21
iGMDRD662JQ-11
iGMDRD594AZD-80551
iGMDRD116CD4372
iGMDRD324CI-10401
iGMDRD435BI-25365
iGMDRD1002rTRAIL1
iGMDRD123Isoevodiamine3
iGMDRD237ABT-7511
iGMDRD292NSC878771
iGMDRD689EX-86781
iGMDRD376Tivozanib1
iGMDRD593CX-54611
iGMDRD759PFI-11
iGMDRD758JW-7-24-11
iGMDRD507GSK6906931
iGMDRD255SB2250023
iGMDRD491TAE-6841
iGMDRD138PX 122
iGMDRD451Serdemetan2
iGMDRD60Quinoclamine2
iGMDRD332A-7700411
iGMDRD399Selumetinib2
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD546BMS-7548071
iGMDRD654SL 0101-11
iGMDRD749ZINC67184531
iGMDRD659Avagacestat (BMS-708163)3
iGMDRD387CHIR-990211
iGMDRD443Linifanib1
iGMDRD313Axitinib1
iGMDRD112Methotrexate1
iGMDRD130Enzastaurin1
iGMDRD776QL-XI-921
iGMDRD280CYTOCHALASIN B2
iGMDRD673LSM-12151
iGMDRD348BMS-3455411
iGMDRD193Fqi12
iGMDRD608Refametinib3
iGMDRD446LY 21832406

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL1B

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