iGMDRD376

Canonical SMILES: CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl

InChI: InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)

InChI Key: SPMVMDHWKHCIDT-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameTivozanib
CHEMBLCHEMBL3426917 CHEMBL2105756 CHEMBL1289494
Pubchem CID9911830
DRUGBANK IDDB11800
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

VEGFRFLT1FLT3KDR

Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BRAItissue: BRAI cancer: BRAIN model num: 0BRAINtissue: BRAIN cancer: Glioblastoma Multiforme (GBM) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
55252 ASXL2 1
4609 MYC 1
3553 IL1B 1
Showing 1 to 4 of 7 rows

Gene in drug-gene network: Network Plot

selumetinib in BRAF mutant tumorsselumetinib in BRAF mutant tumorsPX 12PX 12quinoclaminequinoclaminecytochalasin.Bcytochalasin.BserdemetanserdemetanBI-2536BI-2536isoevodiamineisoevodiamineAZD-1775AZD-1775SB225002SB225002PD0325901PD0325901LY 2183240LY 2183240Tyrphostin AG 1478Tyrphostin AG 1478pevonedistatpevonedistatAvagacestat (BMS-708163)Avagacestat (BMS-708163)RefametinibRefametinibcurcumincurcuminFqi1Fqi1CD437CD437IL1BIL1BBMS-754807BMS-754807BMS-536924BMS-536924navitoclaxnavitoclaxMerck60Merck60BRD6368BRD6368NSC141540NSC141540NSC23766NSC23766BRD7137BRD7137PAC-1PAC-1SirolimusSirolimusCIITACIITAPI-103PI-103Compound 44Compound 44ciclosporinciclosporintipifarnib-P2tipifarnib-P2itraconazoleitraconazoleCompound 110Compound 110bistramide Abistramide AnakiterpiosinnakiterpiosinYK.4.279YK.4.279VX-680VX-680(-)-gallocatechin-3-O-gallate(-)-gallocatechin-3-O-gallateBET inhibitorsBET inhibitorserastinerastinkahalalide Fkahalalide FMYCMYCkinetin ribosidekinetin ribosideMST-312MST-312neopeltolideneopeltolideFK 866FK 866GW-405833GW-405833PD-0332991PD-0332991GW-843682XGW-843682XML162ML162ABT737ABT737SR-II-138ASR-II-138AGMX1778GMX1778Nsc 632839Nsc 632839piperlonguminepiperlongumineteniposideteniposideMDM2/MDMX inhibitorsMDM2/MDMX inhibitors4-methylfasudil4-methylfasudilRB1RB1PP-30PP-30MEK inhibitorsMEK inhibitorsGefitnibGefitnibCHEMBL399379CHEMBL399379cetuximabcetuximabErlotinibErlotinibPanitumumabPanitumumabPI3K pathway inhibitorsPI3K pathway inhibitorsSarcolysinSarcolysinRegorafenibRegorafenibTrametinibTrametinibKRASKRASCDK4/6 inhibitorsCDK4/6 inhibitorsVER 155008VER 155008ubistatin Bubistatin BFedratinibFedratinibPLX-4720PLX-4720DabrafenibDabrafenibVemurafenibVemurafenibChloropentafluorobenzeneChloropentafluorobenzeneBinimetinib (MEK162)Binimetinib (MEK162)NRASNRASBelinostat (PXD101)Belinostat (PXD101)ASXL2ASXL2TivozanibTivozanib

Models in Tivozanib

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
AMP(MYC) gene GDSC BOWEL Colorectal Adenocarcinoma (COADREAD) AV-951 sensitivity in vitro
DEL(CIITA) gene GDSC undefined PANCAN AV-951 sensitivity in vitro
DEL(RB1) gene GDSC BREAST Breast Carcinoma AV-951 sensitivity in vitro
FUS(BCR-ABL) gene GDSC undefined PANCAN AV-951 sensitivity in vitro
¬DEL(3p14.2)&DEL(Xq28) mix GDSC undefined PANCAN AV-951 sensitivity in vitro
MUT(ASXL2) mix GDSC LYMPH Diffuse Large B-Cell Lymphoma (DLBCL) AV-951 sensitivity in vitro
¬AMP(1q32.2)&(7q11.23)|DEL(6q26)&PWU(H2O2) mix GDSC BRAIN Glioblastoma Multiforme (GBM) AV-951 sensitivity in vitro
¬MUT(KRAS)&¬MUT(NRAS)&¬PWU(IL-1)&¬PWU(TLR) mix GDSC BONE Acute Myeloid Leukemia (AML) AV-951 sensitivity in vitro
Showing 1 to 8 of 8 rows

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