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iGMDRD376

Canonical SMILES: CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl

InChI: InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)

InChI Key: SPMVMDHWKHCIDT-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Tivozanib	CHEMBL3426917 CHEMBL2105756 CHEMBL1289494	9911830	DB11800	Alone	Small Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents Benzene Derivatives Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Hydrocarbons Hydrocarbons, Aromatic Hydrocarbons, Cyclic Protein Kinase Inhibitors Receptors, Vascular Endothelial Growth Factor, antagonists & inhibitors Urea

Drug Targets:

VEGFR FLT1 FLT3 KDR

Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3845	KRAS	1
55252	ASXL2	1
4609	MYC	1
3553	IL1B	1
4261	CIITA	1
5925	RB1	1
4893	NRAS	1

Gene in drug-gene network: Network Plot

Models in Tivozanib

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DATATYPES

CLASSFICATION

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