CIITA


Summary: This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
class II major histocompatibility complex transactivatorMIM:600005Ensembl:ENSG00000179583HGNC:HGNC:7067PA3079516p13.13

GO terms in CIITA


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0006955immune response
BPIEAGO:0016310phosphorylation
BPICGO:0032966negative regulation of collagen biosynthetic process
BPIDAGO:0034341response to interferon-gamma
BPIDAGO:0045345positive regulation of MHC class I biosynthetic process
BPICGO:0045348positive regulation of MHC class II biosynthetic process
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046677response to antibiotic
BPTASGO:0060333interferon-gamma-mediated signaling pathway
CCTASGO:0005654nucleoplasm
CCIDAGO:0016605PML body
MFTASGO:0003677DNA binding
MFTASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0005525GTP binding
MFIPIGO:0008022protein C-terminus binding
MFIEAGO:0016301kinase activity
MFIEAGO:0016746transferase activity, transferring acyl groups
MFIPIGO:0033613activating transcription factor binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0044877protein-containing complex binding

Gene expression in normal tissue: CIITA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CIITA


DatabasePathway IDPathway Des.
wikipathwaysWP619Type II interferon signaling (IFNG)
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05340Primary immunodeficiency - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-913531Interferon Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD781Sirolimus4
iGMDRD546BMS-7548076
iGMDRD427ABT7372
iGMDRD670ML 2103
iGMDRD1008SR-II-138A3
iGMDRD772BRD47703
iGMDRD375GW-4058333
iGMDRD280CYTOCHALASIN B5
iGMDRD466Chaetocin2
iGMDRD187BRD98761
iGMDRD294Batimastat2
iGMDRD226ML0063
iGMDRD885Compound 1103
iGMDRD318PAC-16
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD8024-methylfasudil2
iGMDRD451Serdemetan4
iGMDRD524ISX-93
iGMDRD60Quinoclamine3
iGMDRD369TGX-1152
iGMDRD690PRIMA-1MET3
iGMDRD780PP-303
iGMDRD562Navitoclax6
iGMDRD506Fedratinib3
iGMDRD730Kahalalide F3
iGMDRD887Compound 23 citrate2
iGMDRD74Idarubicin3
iGMDRD399Selumetinib4
iGMDRD405PIK-752
iGMDRD523Cyanoquinoline, 113
iGMDRD560MK-22061
iGMDRD512nutlin 33
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD945ML2142
iGMDRD154NSC237664
iGMDRD211(1S,3R)-RSL33
iGMDRD57Chloropentafluorobenzene2
iGMDRD314Tanespimycin3
iGMDRD461VX-11e1
iGMDRD341Triacsin c1
iGMDRD376Tivozanib1
iGMDRD267Oligomycin A3
iGMDRD481Dactolisib3
iGMDRD434BMS-5369246
iGMDRD289Parthenolide1
iGMDRD221Tamoxifen1
iGMDRD158NSC1415404
iGMDRD137Indisulam2
iGMDRD179Shikonin1
iGMDRD300Tozasertib3
iGMDRD366PI-1031
iGMDRD329Merck609
iGMDRD872BRD71376
iGMDRD414MST-3123
iGMDRD871BRD63686

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CIITA

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