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iGMDRD427

Canonical SMILES: CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]

InChI: InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1

InChI Key: HPLNQCPCUACXLM-PGUFJCEWSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
ABT737	CHEMBL376408	11228200	Alone	Small Molecule

Drug Targets:

BCL2 BCL2L1 BCL2L2

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	6
6664	SOX11	3
7074	TIAM1	2
3159	HMGA1	3
471	ATIC	3
79848	CSPP1	2
7535	ZAP70	3
7837	PXDN	6
79054	TRPM8	2
1464	CSPG4	3
7128	TNFAIP3	1
21	ABCA3	4
132	ADK	2
8476	CDC42BPA	6
26191	PTPN22	3
7161	TP73	3
4066	LYL1	3
79947	DHDDS	6
4627	MYH9	5
5546	PRCC	1
8929	PHOX2B	3
2956	MSH6	2
3708	ITPR1	2
1520	CTSS	1
57554	LRRC7	7
1969	EPHA2	2
9706	ULK2	2
9149	DYRK1B	1
7272	TTK	3
347365	ITIH6	5
51347	TAOK3	3
23552	CDK20	1
23097	CDK19	6
2100	ESR2	9
8289	ARID1A	2
8573	CASK	1
51231	VRK3	1
57143	ADCK1	2
4928	NUP98	4
65061	CDK15	3
53616	ADAM22	2
4312	MMP1	3
6597	SMARCA4	8
81035	COLEC12	2
10395	DLC1	5
5133	PDCD1	2
79820	CATSPERB	2
7942	TFEB	3
6657	SOX2	2
390502	SERPINA2	3
23495	TNFRSF13B	3
56776	FMN2	3
4313	MMP2	4
6598	SMARCB1	3
4170	MCL1	3
3694	ITGB6	8
1272	CNTN1	3
9641	IKBKE	3
10142	AKAP9	2
7253	TSHR	3
8749	ADAM18	4
3841	KPNA5	9
340371	NRBP2	3
22821	RASA3	3
6318	SERPINB4	2
604	BCL6	5
202374	STK32A	5
1813	DRD2	3
1387	CREBBP	3
1893	ECM1	1
11329	STK38	3
26039	SS18L1	2
8844	KSR1	6
5788	PTPRC	1
56164	STK31	1
10013	HDAC6	5
5579	PRKCB	5
31	ACACA	2
10178	TENM1	5
9048	ARTN	2
9411	ARHGAP29	2
29998	BICRA	3
8295	TRRAP	6
11122	PTPRT	2
5899	RALB	3
5159	PDGFRB	6
55351	STK32B	3
55300	PI4K2B	3
2120	ETV6	3
51512	GTSE1	2
7158	TP53BP1	7
89910	UBE3B	3
55294	FBXW7	3
6927	HNF1A	2
9578	CDC42BPB	5
4361	MRE11	3
1021	CDK6	3
23522	KAT6B	2
6390	SDHB	1
7852	CXCR4	6
57670	KIAA1549	7
837	CASP4	2
440279	UNC13C	6
340156	MYLK4	5
4610	MYCL	8
4301	AFDN	3
55819	RNF130	6
84033	OBSCN	2
11011	TLK2	3
5900	RALGDS	5
342977	NANOS3	8
256646	NUTM1	3
8767	RIPK2	3
122011	CSNK1A1L	5
3621	ING1	3
2051	EPHB6	6
1586	CYP17A1	1
1591	CYP24A1	3
32	ACACB	1
8852	AKAP4	4
3091	HIF1A	1
6041	RNASEL	4
5468	PPARG	3
200576	PIKFYVE	10
6733	SRPK2	1
6091	ROBO1	2
5330	PLCB2	6
23255	MTCL1	4
114548	NLRP3	2
5984	RFC4	2
9636	ISG15	6
10217	CTDSPL	4
11169	WDHD1	2
10298	PAK4	1
2736	GLI2	3
695	BTK	5
51804	SIX4	3
9098	USP6	2
284217	LAMA1	2
269	AMHR2	2
83931	STK40	1
7037	TFRC	3
1143	CHRNB4	3
2045	EPHA7	3
1992	SERPINB1	7
238	ALK	1
7078	TIMP3	1
22858	ICK	2
2064	ERBB2	6
85443	DCLK3	4
6850	SYK	2
287015	TRIM42	3
83983	TSSK6	3
834	CASP1	4
54899	PXK	1
29775	CARD10	3
4294	MAP3K10	3
1456	CSNK1G3	3
6416	MAP2K4	6
9759	HDAC4	6
1452	CSNK1A1	9
65987	KCTD14	3
158056	MAMDC4	4
50488	MINK1	6
80312	TET1	2
6098	ROS1	3
9472	AKAP6	3
157285	PRAG1	3
9590	AKAP12	3
6917	TCEA1	2
51433	ANAPC5	3
472	ATM	3
28996	HIPK2	5
5924	RASGRF2	3
9096	TBX18	3
9564	BCAR1	2
8038	ADAM12	3
4058	LTK	2
1123	CHN1	8
1496	CTNNA2	7
7010	TEK	2
7533	YWHAH	2
5289	PIK3C3	4
2050	EPHB4	3
2272	FHIT	8
2066	ERBB4	2
7681	MKRN3	3
1647	GADD45A	4
5863	RGL2	3
7184	HSP90B1	2
10062	NR1H3	2
5460	POU5F1	3
9794	MAML1	2
5129	CDK18	3
959	CD40LG	3
284656	EPHA10	4
83694	RPS6KL1	6
5336	PLCG2	5
27347	STK39	3
27086	FOXP1	6
6794	STK11	2
25836	NIPBL	3
8218	CLTCL1	3
57410	SCYL1	2
3791	KDR	2
147746	HIPK4	3
6184	RPN1	3
54498	SMOX	1
84513	PLPP5	3
2263	FGFR2	2
130399	ACVR1C	3
225689	MAPK15	1
7409	VAV1	5
65243	ZFP69B	9
84075	FSCB	3
9967	THRAP3	1
105	ADARB2	2
5604	MAP2K1	3
8874	ARHGEF7	2
10516	FBLN5	2
2309	FOXO3	3
7038	TG	7
3572	IL6ST	1
6197	RPS6KA3	5
136332	LRGUK	5
4436	MSH2	2
50945	TBX22	4
1656	DDX6	3
984	CDK11B	1
7175	TPR	5
80205	CHD9	3
23365	ARHGEF12	2
2081	ERN1	3
8831	SYNGAP1	3
84181	CHD6	4
57578	UNC79	2
4026	LPP	5
2071	ERCC3	4
23269	MGA	4
4089	SMAD4	3
6654	SOS1	3
2060	EPS15	3
1616	DAXX	1
1848	DUSP6	2
2737	GLI3	3
7204	TRIO	3
285220	EPHA6	1
546	ATRX	2
57144	PAK5	3
440275	EIF2AK4	3
8731	RNMT	7
1198	CLK3	2
9972	NUP153	2
50615	IL21R	5
6046	BRD2	3
1514	CTSL	6
2931	GSK3A	4
1000	CDH2	3
4293	MAP3K9	8
90	ACVR1	1
2318	FLNC	3
5530	PPP3CA	3
4803	NGF	4
744	MPPED2	2
8445	DYRK2	1
640	BLK	4
2735	GLI1	1
4609	MYC	2
5789	PTPRD	5
90427	BMF	2
7297	TYK2	3
4684	NCAM1	4
894	CCND2	2
5462	POU5F1B	3
6776	STAT5A	2
51701	NLK	3
833	CARS	3
5592	PRKG1	8
5156	PDGFRA	9
8900	CCNA1	2
375056	MIA3	3
1544	CYP1A2	3
91754	NEK9	3
137872	ADHFE1	3
27330	RPS6KA6	3
3949	LDLR	1
56924	PAK6	3
23005	MAPKBP1	3
7153	TOP2A	5
4790	NFKB1	3
84879	MFSD2A	8
1769	DNAH8	1
8924	HERC2	2
6502	SKP2	3
65268	WNK2	2
79184	BRCC3	3
694	BTG1	2
867	CBL	4
6095	RORA	7
146057	TTBK2	2
57507	ZNF608	1
1677	DFFB	3
84441	MAML2	3
8626	TP63	1
9113	LATS1	1
460	ASTN1	3
8178	ELL	3
9064	MAP3K6	4
5979	RET	2
9321	TRIP11	1
10253	SPRY2	2
5378	PMS1	3
9451	EIF2AK3	1
11262	SP140	3
9509	ADAMTS2	5
23742	NPAP1	7
8312	AXIN1	5
5728	PTEN	4
1487	CTBP1	3
8888	MCM3AP	3
22883	CLSTN1	7
23281	MTUS2	6
3554	IL1R1	2
53836	GPR87	3
6146	RPL22	7
1950	EGF	5
2264	FGFR4	2
658	BMPR1B	2
6498	SKIL	2
1445	CSK	2
8522	GAS7	2
7465	WEE1	6
3577	CXCR1	3
2119	ETV5	6
7059	THBS3	3
7454	WAS	6
7036	TFR2	2
596	BCL2	3
85415	RHPN2	5
10562	OLFM4	12
8028	MLLT10	6
203447	NRK	6
29959	NRBP1	3
54904	NSD3	1
8648	NCOA1	3
9372	ZFYVE9	3
2046	EPHA8	1
8821	INPP4B	3
10595	ERN2	6
344905	ATP13A5	3
5588	PRKCQ	3
51151	SLC45A2	2
5291	PIK3CB	1
3611	ILK	1
1493	CTLA4	6
10076	PTPRU	2
558	AXL	2
126792	B3GALT6	1
57680	CHD8	5
3297	HSF1	3
5581	PRKCE	1
5923	RASGRF1	3
2690	GHR	9
10111	RAD50	3
100124696	TEC	3
6790	AURKA	3
53353	LRP1B	4
5609	MAP2K7	1
152110	NEK10	6
9659	PDE4DIP	2
63976	PRDM16	6
4000	LMNA	3
5927	KDM5A	3
5170	PDPK1	3
5681	PSKH1	3
7099	TLR4	2
1627	DBN1	1
79837	PIP4K2C	5
1906	EDN1	4
11040	PIM2	2
4221	MEN1	3
6194	RPS6	4
65267	WNK3	3
150094	SIK1	4
3984	LIMK1	1
4772	NFATC1	1
6777	STAT5B	3
4261	CIITA	2
84072	HORMAD1	3
23512	SUZ12	3
444	ASPH	2
7046	TGFBR1	2
51167	CYB5R4	2
5087	PBX1	3
6653	SORL1	3
5925	RB1	6
4893	NRAS	7
63923	TNN	3
3131	HLF	2
25	ABL1	2
5324	PLAG1	3
1576	CYP3A4	3
7403	KDM6A	6
1234	CCR5	4
8841	HDAC3	2
197259	MLKL	4
5586	PKN2	2
30849	PIK3R4	2
3480	IGF1R	2
23092	ARHGAP26	3
9935	MAFB	3
9262	STK17B	3
374	AREG	3
139604	MAGEB16	5
5567	PRKACB	1
79966	SCD5	6
4763	NF1	2
57697	FANCM	2
55791	LRIF1	3
1840	DTX1	1
65975	STK33	3
4591	TRIM37	3
5287	PIK3C2B	2
3110	MNX1	3
814	CAMK4	3
23683	PRKD3	3
3679	ITGA7	3
1608	DGKG	1
2178	FANCE	2
27255	CNTN6	1
2444	FRK	3
27151	CPAMD8	3
56155	TEX14	6
5602	MAPK10	5
2892	GRIA3	3
4916	NTRK3	1
11035	RIPK3	3
5624	PROC	1
578	BAK1	3
5590	PRKCZ	3

Gene in drug-gene network: Network Plot

Models in ABT737

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.