WEE1


Summary: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
WEE1 G2 checkpoint kinaseMIM:193525Ensembl:ENSG00000166483HGNC:HGNC:12761PA36611p15.4

GO terms in WEE1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFIBAGO:0004672protein kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIEAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0016301kinase activity
CCIBAGO:0005634nucleus
CCTASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIEAGO:0005737cytoplasm
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPIEAGO:0000226microtubule cytoskeleton organization
BPIBAGO:0007093mitotic cell cycle checkpoint
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0030010establishment of cell polarity
BPIEAGO:0048812neuron projection morphogenesis
BPIEAGO:0051301cell division

Gene expression in normal tissue: WEE1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WEE1


DatabasePathway IDPathway Des.
kegghsa04110Cell cycle - Homo sapiens (human)
pidplk1_pathwayPLK1 signaling events
wikipathwaysWP179Cell Cycle
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP45G1 to S cell cycle control
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-156711Polo-like kinase mediated events
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69242S Phase
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69478G2/M DNA replication checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
reactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
biocartacdc25pathwaycdc25 and chk1 regulatory pathway in response to dna damage
biocartag2pathwaycell cycle: g2/m checkpoint
biocartarbpathwayrb tumor suppressor/checkpoint signaling in response to dna damage

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD6AM-5803
iGMDRD62Platinum1
iGMDRD415LE-1353
iGMDRD77Itraconazole3
iGMDRD121GMX17783
iGMDRD271Brefeldin A3
iGMDRD158NSC1415406
iGMDRD137Indisulam3
iGMDRD5Tyrphostin AG 14781
iGMDRD246NPC261
iGMDRD353PD03259012
iGMDRD871BRD63683
iGMDRD329Merck603
iGMDRD662JQ-13
iGMDRD269Purmorphamine3
iGMDRD405PIK-753
iGMDRD79Gemcitabine1
iGMDRD307Manumycin A3
iGMDRD123Isoevodiamine3
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD85Ursolic acid4
iGMDRD171Pemetrexed6
iGMDRD294Batimastat3
iGMDRD187BRD98763
iGMDRD513BML-2593
iGMDRD8024-methylfasudil3
iGMDRD64Parbendazole3
iGMDRD23Gossypol3
iGMDRD100Zebularine3
iGMDRD188Piperlongumine3
iGMDRD74Idarubicin6
iGMDRD562Navitoclax6
iGMDRD427ABT7376
iGMDRD781Sirolimus3
iGMDRD126Tipifarnib1
iGMDRD387CHIR-990211
iGMDRD425ERASTIN3
iGMDRD1008SR-II-138A3
iGMDRD280CYTOCHALASIN B3
iGMDRD446LY 21832403
iGMDRD193Fqi13

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WEE1

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