WEE1
Summary: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| WEE1 G2 checkpoint kinase | MIM:193525 | Ensembl:ENSG00000166483 | HGNC:HGNC:12761 | PA366 | 11p15.4 |
GO terms in WEE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IEA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IBA | GO:0007093 | mitotic cell cycle checkpoint |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0030010 | establishment of cell polarity |
| BP | IEA | GO:0048812 | neuron projection morphogenesis |
| BP | IEA | GO:0051301 | cell division |
Gene expression in normal tissue: WEE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WEE1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| pid | plk1_pathway | PLK1 signaling events |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP45 | G1 to S cell cycle control |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69478 | G2/M DNA replication checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| reactome | R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| biocarta | cdc25pathway | cdc25 and chk1 regulatory pathway in response to dna damage |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | rbpathway | rb tumor suppressor/checkpoint signaling in response to dna damage |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD6 | AM-580 | 3 |
| iGMDRD62 | Platinum | 1 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD171 | Pemetrexed | 6 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WEE1
CLASSFICATION
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