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WEE1

Summary: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameWEE1 G2 checkpoint kinase OMIM IDMIM:193525 Ensembl IDEnsembl:ENSG00000166483 HGNC IDHGNC:HGNC:12761 PHARMGKB IDPA366 Map Location11p15.4

Gene Categories:

TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE DRUGGABLE GENOME TYROSINE KINASE

GO terms in WEE1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0000287	magnesium ion binding
MF	IBA	GO:0004672	protein kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	TAS	GO:0004713	protein tyrosine kinase activity
MF	IEA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IPI	GO:0005515	protein binding

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Gene expression in normal tissue: WEE1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WEE1

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Database	Pathway ID	Pathway Des.
kegg	hsa04110	Cell cycle - Homo sapiens (human)
pid	plk1_pathway	PLK1 signaling events
wikipathways	WP179	Cell Cycle
wikipathways	WP2446	Retinoblastoma (RB) in Cancer
wikipathways	WP45	G1 to S cell cycle control
reactome	R-HSA-109582	Hemostasis

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD6	AM-580	3
iGMDRD62	Platinum	1
iGMDRD415	LE-135	3
iGMDRD77	Itraconazole	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WEE1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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