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iGMDRD387

Canonical SMILES: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N

InChI: InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)

InChI Key: AQGNHMOJWBZFQQ-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
CHIR-99021	CHEMBL412142	9956120	Alone	Small Molecule

Drug Targets:

GSK3A GSK3B

Drug Pathways:

WNT signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	2
7535	ZAP70	3
10221	TRIB1	3
10987	COPS5	1
132	ADK	3
3383	ICAM1	3
6319	SCD	1
8476	CDC42BPA	2
4291	MLF1	3
2986	GUCY2F	1
57679	ALS2	1
57554	LRRC7	1
3757	KCNH2	1
5295	PIK3R1	1
23552	CDK20	2
23097	CDK19	3
2335	FN1	3
5593	PRKG2	6
83942	TSSK1B	2
3551	IKBKB	3
3326	HSP90AB1	1
2176	FANCC	2
5241	PGR	2
10892	MALT1	3
4313	MMP2	1
1786	DNMT1	2
10863	ADAM28	1
4170	MCL1	3
341676	NEK5	1
340371	NRBP2	3
7048	TGFBR2	1
79934	COQ8B	2
51199	NIN	1
112858	TP53RK	3
1893	ECM1	1
8106	PABPN1	3
2043	EPHA4	2
5788	PTPRC	1
56164	STK31	2
79858	NEK11	2
5314	PKHD1	2
102	ADAM10	3
284521	OR2L13	1
11011	TLK2	3
25937	WWTR1	1
5900	RALGDS	3
9693	RAPGEF2	2
608	TNFRSF17	3
32	ACACB	1
64083	GOLPH3	2
730249	ACOD1	1
11169	WDHD1	1
51804	SIX4	3
9098	USP6	2
284217	LAMA1	2
269	AMHR2	1
7424	VEGFC	1
399979	SNX19	3
375449	MAST4	2
7428	VHL	1
2064	ERBB2	1
57476	GRAMD1B	1
834	CASP1	3
1456	CSNK1G3	4
92	ACVR2A	2
8714	ABCC3	1
6709	SPTAN1	2
219970	GLYATL2	3
1909	EDNRA	3
2068	ERCC2	2
6464	SHC1	2
8515	ITGA10	1
9590	AKAP12	1
51433	ANAPC5	1
83903	HASPIN	2
7533	YWHAH	1
56648	EIF5A2	3
1029	CDKN2A	4
5108	PCM1	2
57523	NYNRIN	1
7157	TP53	3
397	ARHGDIB	1
3791	KDR	1
114788	CSMD3	1
54498	SMOX	1
7422	VEGFA	2
136332	LRGUK	2
4436	MSH2	1
6795	AURKC	3
4904	YBX1	1
57551	TAOK1	3
29072	SETD2	1
51284	TLR7	1
54658	UGT1A1	1
672	BRCA1	2
2668	GDNF	3
11168	PSIP1	2
4139	MARK1	3
9252	RPS6KA5	2
2047	EPHB1	2
10926	DBF4	1
7270	TTF1	1
8731	RNMT	3
1514	CTSL	2
26524	LATS2	2
675	BRCA2	3
3458	IFNG	2
3065	HDAC1	1
4609	MYC	2
54510	PCDH18	1
8021	NUP214	1
1459	CSNK2A2	3
90427	BMF	3
7297	TYK2	2
26278	SACS	1
894	CCND2	1
3553	IL1B	1
1594	CYP27B1	3
5156	PDGFRA	2
7443	VRK1	2
1544	CYP1A2	3
3949	LDLR	3
673	BRAF	3
7153	TOP2A	2
1981	EIF4G1	2
988	CDC5L	1
23532	PRAME	3
4863	NPAT	2
780	DDR1	2
83452	RAB33B	2
6502	SKP2	1
7301	TYRO3	1
9113	LATS1	2
9451	EIF2AK3	1
654780	LOC654780	3
7286	TUFT1	3
3575	IL7R	1
1806	DPYD	3
5728	PTEN	1
2796	GNRH1	3
80124	VCPIP1	3
115701	ALPK2	3
83666	PARP9	2
2897	GRIK1	2
995	CDC25C	3
7465	WEE1	1
2119	ETV5	3
596	BCL2	3
85415	RHPN2	1
8028	MLLT10	1
23411	SIRT1	3
2046	EPHA8	4
128869	PIGU	3
8821	INPP4B	2
5532	PPP3CB	2
2072	ERCC4	2
5291	PIK3CB	2
1493	CTLA4	3
3985	LIMK2	1
860	RUNX2	3
778	CACNA1F	3
53353	LRP1B	1
9659	PDE4DIP	2
5335	PLCG1	3
2194	FASN	1
598	BCL2L1	1
55007	FAM118A	2
5589	PRKCSH	2
23139	MAST2	1
1030	CDKN2B	3
3552	IL1A	1
4330	MN1	2
2122	MECOM	1
51167	CYB5R4	2
5054	SERPINE1	2
196528	ARID2	1
4893	NRAS	3
5584	PRKCI	3
862	RUNX1T1	1
7403	KDM6A	1
1234	CCR5	1
2534	FYN	2
4205	MEF2A	2
7040	TGFB1	2
57120	GOPC	1
3480	IGF1R	1
2261	FGFR3	2
23072	HECW1	1
2073	ERCC5	1
55422	ZNF331	2
3092	HIP1	2
54518	APBB1IP	3
55746	NUP133	1
4763	NF1	2
57697	FANCM	3
94	ACVRL1	1
4593	MUSK	2
4629	MYH11	1
814	CAMK4	1
6868	ADAM17	1
1499	CTNNB1	1
2444	FRK	2
3440	IFNA2	3
5624	PROC	1

Gene in drug-gene network: Network Plot

Models in CHIR-99021

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DATATYPES

CLASSFICATION

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