EIF2AK3
Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 2 alpha kinase 3 | MIM:604032 | Ensembl:ENSG00000172071 | HGNC:HGNC:3255 | PA27687 | 2p11.2 |
GO terms in EIF2AK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001501 | skeletal system development |
| BP | IMP | GO:0001503 | ossification |
| BP | IMP | GO:0001525 | angiogenesis |
| BP | ISS | GO:0002063 | chondrocyte development |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IDA | GO:0006983 | ER overload response |
| BP | ISS | GO:0007029 | endoplasmic reticulum organization |
| BP | IMP | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0010998 | regulation of translational initiation by eIF2 alpha phosphorylation |
| BP | TAS | GO:0017148 | negative regulation of translation |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0019722 | calcium-mediated signaling |
| BP | ISS | GO:0030282 | bone mineralization |
| BP | IDA | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | TAS | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | IMP | GO:0031018 | endocrine pancreas development |
| BP | ISS | GO:0031642 | negative regulation of myelination |
| BP | TAS | GO:0032057 | negative regulation of translational initiation in response to stress |
| BP | IMP | GO:0034198 | cellular response to amino acid starvation |
| BP | IMP | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IMP | GO:0036492 | eiF2alpha phosphorylation in response to endoplasmic reticulum stress |
| BP | TAS | GO:0036492 | eiF2alpha phosphorylation in response to endoplasmic reticulum stress |
| BP | TAS | GO:0036499 | PERK-mediated unfolded protein response |
| BP | IMP | GO:0042149 | cellular response to glucose starvation |
| BP | IMP | GO:0045943 | positive regulation of transcription by RNA polymerase I |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0048009 | insulin-like growth factor receptor signaling pathway |
| BP | IMP | GO:0051260 | protein homooligomerization |
| BP | ISS | GO:0060734 | regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation |
| BP | IMP | GO:0070417 | cellular response to cold |
| BP | ISS | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IMP | GO:1902235 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| BP | IEA | GO:1990737 | response to manganese-induced endoplasmic reticulum stress |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IC | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005789 | endoplasmic reticulum membrane |
| CC | NAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0022626 | cytosolic ribosome |
| CC | NAS | GO:0030176 | integral component of endoplasmic reticulum membrane |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IDA | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IMP | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | TAS | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0051879 | Hsp90 protein binding |
Gene expression in normal tissue: EIF2AK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF2AK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-381042 | PERK regulates gene expression |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| biocarta | eif2pathway | regulation of eif2 |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| wikipathways | WP107 | Translation Factors |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD380 | Pifithrin-alpha | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD224 | Necrostatin-1 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD251 | ML162 | 4 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF2AK3
CLASSFICATION
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