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EIF2AK3

Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameeukaryotic translation initiation factor 2 alpha kinase 3 OMIM IDMIM:604032 Ensembl IDEnsembl:ENSG00000172071 HGNC IDHGNC:HGNC:3255 PHARMGKB IDPA27687 Map Location2p11.2

Gene Categories:

SERINE THREONINE KINASE PROTEASE KINASE DRUGGABLE GENOME

GO terms in EIF2AK3

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	ISS	GO:0001501	skeletal system development
BP	IMP	GO:0001503	ossification
BP	IMP	GO:0001525	angiogenesis
BP	ISS	GO:0002063	chondrocyte development
BP	ISS	GO:0006468	protein phosphorylation
BP	ISS	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process

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Gene expression in normal tissue: EIF2AK3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EIF2AK3

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-381042	PERK regulates gene expression
reactome	R-HSA-381119	Unfolded Protein Response (UPR)
reactome	R-HSA-392499	Metabolism of proteins
biocarta	eif2pathway	regulation of eif2
kegg	hsa04137	Mitophagy - animal - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD446	LY 2183240	4
iGMDRD152	179324-69-7	3
iGMDRD193	Fqi1	5
iGMDRD380	Pifithrin-alpha	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EIF2AK3

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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