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iGMDRD84

Canonical SMILES: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)C

InChI: InChI=1S/C24H38O6/c1-5-15(3)24(29)30-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-18(25)12-19(26)13-22(27)28/h6-7,10,14-16,18-21,23,25-26H,5,8-9,11-13H2,1-4H3,(H,27,28)/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

InChI Key: QLJODMDSTUBWDW-BXMDZJJMSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Lovastatin acid	CHEMBL1201373	64727	DB03785	Alone	Small Molecule

Drug Targets:

HMGCR mvaA (P13702)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
8019	BRD3	1
5027	P2RX7	2
1464	CSPG4	2
21	ABCA3	3
3383	ICAM1	5
6774	STAT3	3
5933	RBL1	1
8476	CDC42BPA	2
4926	NUMA1	3
11183	MAP4K5	1
2986	GUCY2F	4
2048	EPHB2	3
2956	MSH6	2
2200	FBN1	1
3708	ITPR1	2
1520	CTSS	3
57554	LRRC7	3
7272	TTK	2
4750	NEK1	2
55215	FANCI	3
8289	ARID1A	2
80070	ADAMTS20	3
8573	CASK	2
51129	ANGPTL4	3
4312	MMP1	3
9475	ROCK2	3
9869	SETDB1	2
7444	VRK2	2
5079	PAX5	2
64783	RBM15	3
10892	MALT1	2
1786	DNMT1	1
1607	DGKB	1
3066	HDAC2	2
10142	AKAP9	2
22853	LMTK2	3
7253	TSHR	2
27	ABL2	3
22821	RASA3	2
4149	MAX	3
7048	TGFBR2	2
80122	MAP3K19	2
1813	DRD2	1
1387	CREBBP	4
2043	EPHA4	2
4881	NPR1	3
85021	REPS1	2
8295	TRRAP	3
9024	BRSK2	3
7373	COL14A1	3
5166	PDK4	2
4851	NOTCH1	6
5314	PKHD1	5
139378	ADGRG4	3
55294	FBXW7	3
55728	N4BP2	2
284521	OR2L13	3
440279	UNC13C	3
4610	MYCL	4
84033	OBSCN	4
5607	MAP2K5	2
152137	CCDC50	2
1540	CYLD	2
8600	TNFSF11	3
7025	NR2F1	3
9693	RAPGEF2	2
8549	LGR5	1
32	ACACB	4
2242	FES	3
3091	HIF1A	2
22984	PDCD11	1
9175	MAP3K13	2
8313	AXIN2	1
6733	SRPK2	3
6091	ROBO1	5
2042	EPHA3	2
80129	CCDC170	1
51804	SIX4	2
284217	LAMA1	5
269	AMHR2	2
55681	SCYL2	3
2045	EPHA7	3
375449	MAST4	3
6850	SYK	2
57476	GRAMD1B	1
8643	PTCH2	3
8395	PIP5K1B	2
54899	PXK	2
23191	CYFIP1	1
783	CACNB2	2
6416	MAP2K4	2
9759	HDAC4	4
57510	XPO5	2
8215	DVL1P1	2
50488	MINK1	2
5591	PRKDC	1
80312	TET1	1
6464	SHC1	2
6098	ROS1	2
9472	AKAP6	3
2778	GNAS	3
3685	ITGAV	2
80243	PREX2	3
5229	PGGT1B	3
575	ADGRB1	2
53942	CNTN5	2
4087	SMAD2	2
1123	CHN1	1
1496	CTNNA2	6
5450	POU2AF1	2
2066	ERBB4	2
5863	RGL2	2
7184	HSP90B1	2
9794	MAML1	2
57523	NYNRIN	5
657	BMPR1A	3
5336	PLCG2	3
11143	KAT7	3
28514	DLL1	3
27347	STK39	2
58508	KMT2C	3
6092	ROBO2	3
7704	ZBTB16	2
4173	MCM4	1
4857	NOVA1	1
8218	CLTCL1	2
114788	CSMD3	4
3000	GUCY2D	3
11213	IRAK3	3
84075	FSCB	3
369	ARAF	1
3187	HNRNPH1	2
50945	TBX22	4
652	BMP4	5
6035	RNASE1	3
676	BRDT	3
5650	KLK7	3
7175	TPR	3
5871	MAP4K2	3
9401	RECQL4	3
80205	CHD9	3
4437	MSH3	3
2071	ERCC3	3
23269	MGA	6
3643	INSR	3
23469	PHF3	3
4089	SMAD4	1
51284	TLR7	1
170692	ADAMTS18	2
6654	SOS1	4
672	BRCA1	2
7204	TRIO	3
51366	UBR5	4
23678	SGK3	2
5297	PI4KA	3
10769	PLK2	1
57144	PAK5	3
340533	NEXMIF	3
92335	STRADA	3
1514	CTSL	2
5034	P4HB	2
1000	CDH2	3
1687	GSDME	2
4293	MAP3K9	1
2318	FLNC	3
26166	RGS22	3
744	MPPED2	2
3065	HDAC1	3
64333	ARHGAP9	2
1459	CSNK2A2	1
8795	TNFRSF10B	3
7297	TYK2	2
26278	SACS	4
894	CCND2	4
204851	HIPK1	3
5187	PER1	1
10000	AKT3	3
91754	NEK9	3
203102	ADAM32	3
57082	KNL1	1
84630	TTBK1	2
4790	NFKB1	3
1769	DNAH8	2
4863	NPAT	2
780	DDR1	2
57538	ALPK3	3
5598	MAPK7	3
339345	NANOS2	3
89795	NAV3	2
6095	RORA	2
93273	LEMD1	3
5205	ATP8B1	1
7468	NSD2	2
8029	CUBN	1
9113	LATS1	2
5294	PIK3CG	3
9451	EIF2AK3	2
51555	PEX5L	6
55290	BRF2	3
8621	CDK13	2
10010	TANK	3
8312	AXIN1	3
57521	RPTOR	1
115701	ALPK2	2
53836	GPR87	1
1950	EGF	2
7273	TTN	4
6787	NEK4	2
387	RHOA	2
79012	CAMKV	2
9372	ZFYVE9	3
54861	SNRK	3
2046	EPHA8	3
7150	TOP1	1
8805	TRIM24	1
23305	ACSL6	1
4297	KMT2A	2
3985	LIMK2	3
317	APAF1	1
2317	FLNB	3
10111	RAD50	1
53353	LRP1B	7
5609	MAP2K7	3
63976	PRDM16	4
54101	RIPK4	3
6093	ROCK1	3
3557	IL1RN	3
3624	INHBA	3
5927	KDM5A	2
5587	PRKD1	3
5170	PDPK1	1
3717	JAK2	2
7099	TLR4	3
2157	F8	4
7227	TRPS1	3
5506	PPP1R3A	3
8899	PRPF4B	2
8428	STK24	4
2719	GPC3	1
84072	HORMAD1	3
2122	MECOM	3
51167	CYB5R4	3
5087	PBX1	1
1209	CLPTM1	2
63923	TNN	3
3691	ITGB4	2
54790	TET2	3
4638	MYLK	3
197259	MLKL	2
2011	MARK2	3
11086	ADAM29	1
142	PARP1	3
2261	FGFR3	3
23072	HECW1	3
1013	CDH15	3
595	CCND1	3
4763	NF1	3
57697	FANCM	2
55791	LRIF1	3
9625	AATK	2
63893	UBE2O	1
10891	PPARGC1A	1
5288	PIK3C2G	3
2044	EPHA5	4
4593	MUSK	2
4629	MYH11	3
4193	MDM2	5
6868	ADAM17	1
23112	TNRC6B	2
27255	CNTN6	3
57699	CPNE5	3
5885	RAD21	3
3895	KTN1	3
1499	CTNNB1	1
2444	FRK	1
27151	CPAMD8	2
64328	XPO4	3
2892	GRIA3	2
5624	PROC	2
5685	PSMA4	3
1488	CTBP2	3

Gene in drug-gene network: Network Plot

Models in Lovastatin acid

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.