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XPO4

Summary: XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
exportin 4	MIM:611449	Ensembl:ENSG00000132953	HGNC:HGNC:17796	PA134866468	13q12.11

Gene Categories:

TRANSPORTER

GO terms in XPO4

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0005643	nuclear pore
CC	IDA	GO:0005654	nucleoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
BP	IBA	GO:0006611	protein export from nucleus
BP	IEA	GO:0015031	protein transport
BP	IMP	GO:0046827	positive regulation of protein export from nucleus
BP	IEA	GO:0051168	nuclear export
MF	IBA	GO:0005049	nuclear export signal receptor activity
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: XPO4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in XPO4

Database	Pathway ID	Pathway Des.
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
wikipathways	WP3302	eIF5A regulation in response to inhibition of the nuclear export system

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD399	Selumetinib	3
iGMDRD446	LY 2183240	3
iGMDRD314	Tanespimycin	3
iGMDRD280	CYTOCHALASIN B	3
iGMDRD679	Bistramide A	2
iGMDRD394	BX-795	3
iGMDRD886	Compound 1541A	4
iGMDRD511	CHEMBL399379	3
iGMDRD158	NSC141540	3
iGMDRD84	Lovastatin acid	3
iGMDRD77	Itraconazole	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in XPO4

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.