CDC42BPA
Summary: The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CDC42 binding protein kinase alpha | MIM:603412 | Ensembl:ENSG00000143776 | HGNC:HGNC:1737 | PA26267 | 1q42.13 |
GO terms in CDC42BPA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0016477 | cell migration |
| BP | IMP | GO:0031032 | actomyosin structure organization |
| BP | IDA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005911 | cell-cell junction |
| CC | ISS | GO:0030027 | lamellipodium |
| CC | ISS | GO:0031252 | cell leading edge |
| CC | IDA | GO:0042641 | actomyosin |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: CDC42BPA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD481 | Dactolisib | 6 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD359 | OSW-1 | 5 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD150 | RITA | 2 |
| iGMDRD560 | MK-2206 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC42BPA
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