CDC42BPA
Summary: The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603412 Ensembl IDEnsembl:ENSG00000143776 HGNC IDHGNC:HGNC:1737 PHARMGKB IDPA26267 Map Location1q42.13 | |||||
GO terms in CDC42BPA
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0016477 | cell migration |
| BP | IMP | GO:0031032 | actomyosin structure organization |
| BP | IDA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| CC | IEA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: CDC42BPA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC42BPA
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cdc42_pathway | CDC42 signaling events |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC42BPA
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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