CDC42BPA


Summary: The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CDC42 binding protein kinase alphaMIM:603412Ensembl:ENSG00000143776HGNC:HGNC:1737PA262671q42.13

GO terms in CDC42BPA


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0016477cell migration
BPIMPGO:0031032actomyosin structure organization
BPIDAGO:0031532actin cytoskeleton reorganization
BPIEAGO:0035556intracellular signal transduction
CCIEAGO:0005737cytoplasm
CCISSGO:0005911cell-cell junction
CCISSGO:0030027lamellipodium
CCISSGO:0031252cell leading edge
CCIDAGO:0042641actomyosin
CCHDAGO:0070062extracellular exosome
MFIDAGO:0000287magnesium ion binding
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: CDC42BPA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDC42BPA


DatabasePathway IDPathway Des.
pidcdc42_pathwayCDC42 signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib3
iGMDRD188Piperlongumine2
iGMDRD562Navitoclax2
iGMDRD398Sepantronium3
iGMDRD506Fedratinib2
iGMDRD662JQ-13
iGMDRD888Compound 441
iGMDRD64Parbendazole2
iGMDRD246NPC262
iGMDRD505Pevonedistat6
iGMDRD524ISX-93
iGMDRD138PX 122
iGMDRD158NSC1415402
iGMDRD513BML-2593
iGMDRD705Nakiterpiosin3
iGMDRD481Dactolisib6
iGMDRD885Compound 1102
iGMDRD226ML0063
iGMDRD152179324-69-72
iGMDRD351GW843682X3
iGMDRD123Isoevodiamine4
iGMDRD297Austocystin D2
iGMDRD359OSW-15
iGMDRD433Lexibulin1
iGMDRD126Tipifarnib3
iGMDRD84Lovastatin acid2
iGMDRD1008SR-II-138A2
iGMDRD387CHIR-990212
iGMDRD427ABT7376
iGMDRD150RITA2
iGMDRD560MK-22062

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDC42BPA

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