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iGMDRD150

Canonical SMILES: C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO

InChI: InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2

InChI Key: KZENBFUSKMWCJF-UHFFFAOYSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
RITA	374536	Alone	Small Molecule

Drug Targets:

MDM2 TP53

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
1105	CHD1	2
6664	SOX11	1
81037	CLPTM1L	4
7837	PXDN	2
1464	CSPG4	6
23085	ERC1	3
9261	MAPKAPK2	4
132	ADK	1
6319	SCD	3
8476	CDC42BPA	2
79947	DHDDS	1
5546	PRCC	2
150465	TTL	6
57554	LRRC7	3
93	ACVR2B	10
4750	NEK1	2
5295	PIK3R1	2
8289	ARID1A	2
6756	SSX1	3
701	BUB1B	2
4928	NUP98	3
5593	PRKG2	3
53616	ADAM22	7
4312	MMP1	1
6938	TCF12	7
3326	HSP90AB1	2
9869	SETDB1	3
8780	RIOK3	3
10395	DLC1	1
5241	PGR	2
353345	GPR141	3
390502	SERPINA2	7
5754	PTK7	8
56776	FMN2	6
51684	SUFU	5
10863	ADAM28	3
1607	DGKB	3
9641	IKBKE	3
55781	RIOK2	1
23310	NCAPD3	2
10645	CAMKK2	3
8749	ADAM18	4
2241	FER	7
1404	HAPLN1	2
1545	CYP1B1	2
140469	MYO3B	5
577	ADGRB3	3
202374	STK32A	3
1893	ECM1	4
5756	TWF1	1
3727	JUND	3
51119	SBDS	1
56164	STK31	8
10013	HDAC6	7
31	ACACA	4
10178	TENM1	2
9070	ASH2L	3
5533	PPP3CC	2
3055	HCK	3
1111	CHEK1	3
10438	C1D	6
11122	PTPRT	4
23617	TSSK2	2
6722	SRF	1
9024	BRSK2	2
5396	PRRX1	2
5159	PDGFRB	1
5465	PPARA	1
4851	NOTCH1	3
5605	MAP2K2	6
139378	ADGRG4	3
7158	TP53BP1	7
55294	FBXW7	5
2033	EP300	3
6927	HNF1A	4
5664	PSEN2	3
4361	MRE11	4
83439	TCF7L1	2
1454	CSNK1E	1
10006	ABI1	2
54477	PLEKHA5	1
837	CASP4	2
4610	MYCL	3
4301	AFDN	6
55819	RNF130	6
5607	MAP2K5	2
342977	NANOS3	1
7025	NR2F1	2
1880	GPR183	7
122011	CSNK1A1L	3
23012	STK38L	1
169436	STKLD1	2
4478	MSN	3
6256	RXRA	3
22806	IKZF3	1
7416	VDAC1	3
4005	LMO2	2
3645	INSRR	1
22984	PDCD11	3
8313	AXIN2	8
2042	EPHA3	2
1050	CEBPA	3
2260	FGFR1	1
730249	ACOD1	3
80129	CCDC170	2
10217	CTDSPL	6
4216	MAP3K4	5
6198	RPS6KB1	4
29904	EEF2K	1
597	BCL2A1	1
695	BTK	2
83990	BRIP1	4
51804	SIX4	3
3688	ITGB1	2
1984	EIF5A	3
284217	LAMA1	2
269	AMHR2	3
7037	TFRC	1
4982	TNFRSF11B	4
23405	DICER1	3
1992	SERPINB1	3
7078	TIMP3	2
171019	ADAMTS19	3
375449	MAST4	6
4752	NEK3	3
7428	VHL	2
983	CDK1	1
57476	GRAMD1B	6
65217	PCDH15	3
286826	LIN9	3
5573	PRKAR1A	3
5127	CDK16	2
6416	MAP2K4	10
7525	YES1	2
1452	CSNK1A1	4
50488	MINK1	3
5591	PRKDC	2
79705	LRRK1	3
5568	PRKACG	2
3685	ITGAV	2
3667	IRS1	1
472	ATM	3
8945	BTRC	6
1009	CDH11	3
83903	HASPIN	3
728642	CDK11A	2
28996	HIPK2	2
575	ADGRB1	2
53942	CNTN5	4
5924	RASGRF2	6
84433	CARD11	3
4804	NGFR	4
6792	CDKL5	5
7010	TEK	10
5289	PIK3C3	3
23152	CIC	7
7681	MKRN3	2
8798	DYRK4	6
5863	RGL2	2
9319	TRIP13	3
7184	HSP90B1	2
5129	CDK18	1
27436	EML4	2
284656	EPHA10	1
57523	NYNRIN	2
8576	STK16	3
657	BMPR1A	2
861	RUNX1	1
28514	DLL1	2
7157	TP53	4
4088	SMAD3	3
27086	FOXP1	9
4173	MCM4	8
57194	ATP10A	10
5910	RAP1GDS1	3
10114	HIPK3	2
7170	TPM3	3
4292	MLH1	2
54498	SMOX	5
572	BAD	4
106480993	RN7SL263P	3
8408	ULK1	3
7409	VAV1	6
1649	DDIT3	3
84075	FSCB	2
105	ADARB2	3
7038	TG	2
3572	IL6ST	10
57188	ADAMTSL3	1
50945	TBX22	3
676	BRDT	3
1441	CSF3R	2
5650	KLK7	8
23365	ARHGEF12	7
84181	CHD6	5
57578	UNC79	3
10499	NCOA2	3
51284	TLR7	4
672	BRCA1	3
1616	DAXX	4
2668	GDNF	4
2737	GLI3	3
23373	CRTC1	1
9448	MAP4K4	2
5606	MAP2K3	2
501	ALDH7A1	6
10769	PLK2	3
56997	COQ8A	2
57144	PAK5	6
8216	LZTR1	2
286133	SCARA5	6
8731	RNMT	2
50615	IL21R	2
1514	CTSL	6
4145	MATK	6
6391	SDHC	6
7043	TGFB3	1
5530	PPP3CA	1
675	BRCA2	4
4803	NGF	2
7075	TIE1	3
4609	MYC	1
11064	CNTRL	3
5155	PDGFB	1
8795	TNFRSF10B	2
5462	POU5F1B	2
6776	STAT5A	5
51265	CDKL3	3
5592	PRKG1	5
1653	DDX1	15
137872	ADHFE1	2
6872	TAF1	3
673	BRAF	1
57082	KNL1	2
1981	EIF4G1	3
5781	PTPN11	4
23532	PRAME	3
4863	NPAT	5
8924	HERC2	2
120892	LRRK2	5
65268	WNK2	1
11126	CD160	3
6095	RORA	6
146057	TTBK2	2
57507	ZNF608	2
84441	MAML2	3
8029	CUBN	2
9113	LATS1	2
4298	MLLT1	2
9321	TRIP11	5
9451	EIF2AK3	3
2017	CTTN	5
8491	MAP4K3	3
266747	RGL4	1
3654	IRAK1	3
23742	NPAP1	3
23049	SMG1	3
8312	AXIN1	3
57521	RPTOR	3
140609	NEK7	3
100187828	HBD	1
22883	CLSTN1	10
667	DST	4
3554	IL1R1	2
352909	DNAAF3	1
2188	FANCF	3
6146	RPL22	7
85409	NKD2	3
6009	RHEB	9
1676	DFFA	1
28954	REM1	3
91807	MYLK3	6
79834	PEAK1	16
23332	CLASP1	1
7059	THBS3	3
8028	MLLT10	3
54904	NSD3	8
8648	NCOA1	3
9372	ZFYVE9	7
10249	GLYAT	3
1027	CDKN1B	2
128869	PIGU	2
10243	GPHN	3
5532	PPP3CB	3
8394	PIP5K1A	3
2353	FOS	3
51151	SLC45A2	1
1493	CTLA4	5
10076	PTPRU	3
7248	TSC1	2
2932	GSK3B	3
5923	RASGRF1	3
2317	FLNB	5
9021	SOCS3	5
100124696	TEC	12
6790	AURKA	6
9223	MAGI1	3
778	CACNA1F	2
140913	PPIAP10	3
9659	PDE4DIP	3
63976	PRDM16	2
7293	TNFRSF4	2
283455	KSR2	4
131890	GRK7	3
5927	KDM5A	3
598	BCL2L1	1
3579	CXCR2	3
5587	PRKD1	1
1719	DHFR	3
57007	ACKR3	6
8317	CDC7	5
3717	JAK2	2
23139	MAST2	2
2157	F8	3
53335	BCL11A	4
3709	ITPR2	2
57147	SCYL3	6
6778	STAT6	2
4221	MEN1	6
4067	LYN	3
6194	RPS6	3
8428	STK24	5
4772	NFATC1	5
51562	MBIP	2
3977	LIFR	3
7112	TMPO	3
84072	HORMAD1	4
170685	NUDT10	2
7046	TGFBR1	2
7913	DEK	2
2122	MECOM	2
5087	PBX1	3
3815	KIT	5
2903	GRIN2A	4
63923	TNN	3
1576	CYP3A4	7
7403	KDM6A	2
2308	FOXO1	3
7508	XPC	2
112268437	LOC112268437	2
3480	IGF1R	2
51135	IRAK4	1
55869	HDAC8	6
11086	ADAM29	4
55422	ZNF331	3
54518	APBB1IP	3
4763	NF1	3
57697	FANCM	8
1612	DAPK1	5
5260	PHKG1	3
55791	LRIF1	3
4613	MYCN	9
1840	DTX1	2
5288	PIK3C2G	2
2044	EPHA5	3
10048	RANBP9	2
1608	DGKG	3
1803	DPP4	1
654790	PCP4L1	1
1499	CTNNB1	3
2444	FRK	3
5602	MAPK10	2
4486	MST1R	3
578	BAK1	6

Gene in drug-gene network: Network Plot

Models in RITA

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.