RANBP9
Summary: This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAN binding protein 9 | MIM:603854 | Ensembl:ENSG00000010017 | HGNC:HGNC:13727 | PA34215 | 6p23 |
GO terms in RANBP9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008536 | Ran GTPase binding |
| MF | IPI | GO:0019899 | enzyme binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005875 | microtubule associated complex |
| CC | IEA | GO:0005886 | plasma membrane |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | NAS | GO:0007020 | microtubule nucleation |
| BP | TAS | GO:0007411 | axon guidance |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | IMP | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
Gene expression in normal tissue: RANBP9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RANBP9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-8851805 | MET activates RAS signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_BDNF | BDNF |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RANBP9
CLASSFICATION
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