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iGMDRD420

Canonical SMILES: CC1CCC2CC(OC(=O)CC3CC(CC(O3)CC(CC1O2)OC)OC(=O)C=CCCC4=COC(=N4)C=CCNC(=O)OC)C=CCC(C)C

InChI: InChI=1S/C38H56N2O10/c1-25(2)10-8-12-28-18-29-16-15-26(3)34(48-29)22-30(44-4)19-31-20-32(21-33(47-31)23-37(42)49-28)50-36(41)14-7-6-11-27-24-46-35(40-27)13-9-17-39-38(43)45-5/h7-9,12-14,24-26,28-34H,6,10-11,15-23H2,1-5H3,(H,39,43)/b12-8+,13-9-,14-7-/t26-,28-,29-,30+,31+,32+,33+,34+/m0/s1

InChI Key: ZZQYLRUTULGFDB-MRSXXGGWSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
Leucascandrolide A	10818500	Alone	Small Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	2
1105	CHD1	1
27125	AFF4	3
4854	NOTCH3	5
8999	CDKL2	3
7074	TIAM1	3
10903	MTMR11	3
7837	PXDN	3
10641	NPRL2	1
6491	STIL	1
11183	MAP4K5	4
79947	DHDDS	2
4627	MYH9	4
2956	MSH6	3
347365	ITIH6	2
3757	KCNH2	3
51347	TAOK3	3
2100	ESR2	2
8289	ARID1A	5
80070	ADAMTS20	2
8573	CASK	2
84700	MYO18B	2
5593	PRKG2	3
53616	ADAM22	4
2475	MTOR	3
6597	SMARCA4	1
4036	LRP2	3
8780	RIOK3	3
843	CASP10	3
3069	HDLBP	2
390502	SERPINA2	2
23310	NCAPD3	4
5298	PI4KB	3
55534	MAML3	3
1404	HAPLN1	3
79934	COQ8B	1
51199	NIN	2
28231	SLCO4A1	3
1893	ECM1	2
8844	KSR1	6
5467	PPARD	3
11200	CHEK2	3
1602	DACH1	5
10178	TENM1	2
5966	REL	2
9411	ARHGAP29	2
3604	TNFRSF9	2
8295	TRRAP	3
2977	GUCY1A2	3
10438	C1D	5
5159	PDGFRB	6
7373	COL14A1	2
10215	OLIG2	1
139378	ADGRG4	3
10295	BCKDK	2
2033	EP300	7
6927	HNF1A	4
641	BLM	3
23522	KAT6B	5
55728	N4BP2	2
7852	CXCR4	3
54477	PLEKHA5	3
440279	UNC13C	5
4301	AFDN	6
84033	OBSCN	6
152137	CCDC50	1
8767	RIPK2	5
3621	ING1	1
9693	RAPGEF2	3
1586	CYP17A1	2
6256	RXRA	2
8852	AKAP4	3
3556	IL1RAP	3
2242	FES	3
2260	FGFR1	3
116986	AGAP2	5
9636	ISG15	5
2736	GLI2	2
2908	NR3C1	2
83990	BRIP1	2
7088	TLE1	2
284217	LAMA1	5
23405	DICER1	1
1992	SERPINB1	6
171019	ADAMTS19	3
375449	MAST4	1
65266	WNK4	2
6850	SYK	2
57476	GRAMD1B	1
65217	PCDH15	2
8395	PIP5K1B	3
23191	CYFIP1	3
23387	SIK3	6
1456	CSNK1G3	4
4140	MARK3	2
6416	MAP2K4	5
9759	HDAC4	2
57510	XPO5	3
5286	PIK3C2A	2
10087	COL4A3BP	3
6793	STK10	3
5591	PRKDC	6
8859	STK19	3
6098	ROS1	2
9472	AKAP6	2
472	ATM	7
8945	BTRC	2
2580	GAK	3
139285	AMER1	3
83903	HASPIN	2
8148	TAF15	2
575	ADGRB1	2
53942	CNTN5	5
5924	RASGRF2	3
4058	LTK	2
7010	TEK	3
898	CCNE1	6
23152	CIC	3
2272	FHIT	3
5327	PLAT	5
5863	RGL2	2
10290	SPEG	2
2201	FBN2	7
5108	PCM1	3
57523	NYNRIN	3
2868	GRK4	2
58508	KMT2C	4
7157	TP53	2
2099	ESR1	2
6092	ROBO2	2
4602	MYB	2
79058	ASPSCR1	2
4857	NOVA1	2
25836	NIPBL	2
397	ARHGDIB	3
5910	RAP1GDS1	6
10114	HIPK3	2
4292	MLH1	5
84513	PLPP5	6
2263	FGFR2	3
84075	FSCB	4
2309	FOXO3	3
7038	TG	3
3187	HNRNPH1	3
65125	WNK1	1
136332	LRGUK	5
652	BMP4	2
5871	MAP4K2	3
80205	CHD9	6
3718	JAK3	3
4026	LPP	2
8997	KALRN	3
7994	KAT6A	3
3643	INSR	3
23469	PHF3	3
6654	SOS1	3
4139	MARK1	5
7204	TRIO	3
10733	PLK4	2
835	CASP2	2
9448	MAP4K4	1
285220	EPHA6	2
3426	CFI	2
3417	IDH1	2
2047	EPHB1	2
10926	DBF4	2
30827	CXXC1	3
440275	EIF2AK4	5
50615	IL21R	2
3720	JARID2	2
5034	P4HB	3
253260	RICTOR	3
10565	ARFGEF1	3
675	BRCA2	6
8445	DYRK2	6
2735	GLI1	2
3065	HDAC1	3
2624	GATA2	3
3308	HSPA4	6
5789	PTPRD	12
8021	NUP214	2
26278	SACS	6
29951	PDZRN4	3
51265	CDKL3	2
8900	CCNA1	4
5187	PER1	2
7917	BAG6	2
27330	RPS6KA6	5
673	BRAF	4
7153	TOP2A	6
1981	EIF4G1	4
1213	CLTC	3
4790	NFKB1	3
1769	DNAH8	9
22976	PAXIP1	3
4863	NPAT	2
83452	RAB33B	2
8924	HERC2	5
6469	SHH	3
120892	LRRK2	3
89795	NAV3	2
6095	RORA	3
1024	CDK8	3
4298	MLLT1	3
9509	ADAMTS2	5
4791	NFKB2	3
23396	PIP5K1C	5
23742	NPAP1	2
51592	TRIM33	2
8888	MCM3AP	2
4914	NTRK1	3
667	DST	4
23281	MTUS2	7
4004	LMO1	3
352909	DNAAF3	3
1950	EGF	3
2870	GRK6	3
7273	TTN	4
79834	PEAK1	3
2119	ETV5	6
85415	RHPN2	2
54861	SNRK	2
84930	MASTL	2
282974	STK32C	3
22843	PPM1E	1
23305	ACSL6	3
4297	KMT2A	2
558	AXL	1
5923	RASGRF1	6
2690	GHR	3
10111	RAD50	3
1281	COL3A1	3
9659	PDE4DIP	5
9201	DCLK1	2
283455	KSR2	2
3624	INHBA	3
4628	MYH10	3
5927	KDM5A	2
2213	FCGR2B	3
5587	PRKD1	4
5589	PRKCSH	3
5170	PDPK1	2
7227	TRPS1	3
1627	DBN1	5
6778	STAT6	5
8428	STK24	3
3977	LIFR	3
7046	TGFBR1	3
8536	CAMK1	3
2122	MECOM	6
5925	RB1	2
4217	MAP3K5	3
1515	CTSV	3
4893	NRAS	2
2074	ERCC6	2
10420	TESK2	1
7403	KDM6A	4
4638	MYLK	3
55959	SULF2	4
11086	ADAM29	2
142	PARP1	3
2261	FGFR3	2
23072	HECW1	1
8321	FZD1	3
4763	NF1	6
55791	LRIF1	3
9625	AATK	2
1994	ELAVL1	3
4286	MITF	3
4629	MYH11	3
10048	RANBP9	3
1608	DGKG	1
2178	FANCE	2
27255	CNTN6	2
83732	RIOK1	3
1499	CTNNB1	3
3440	IFNA2	11
4916	NTRK3	5
167359	NIM1K	2
5624	PROC	3
5970	RELA	2
26206	SPAG8	3

Gene in drug-gene network: Network Plot

Models in Leucascandrolide A

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.