MARK3


Summary: The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
microtubule affinity regulating kinase 3MIM:602678Ensembl:ENSG00000075413HGNC:HGNC:6897PA3064014q32.32-q32.33

GO terms in MARK3


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFNASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0050321tau-protein kinase activity
MFIMPGO:0050321tau-protein kinase activity
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCNASGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIDAGO:0030425dendrite
CCHDAGO:0070062extracellular exosome
BPTASGO:0000165MAPK cascade
BPIBAGO:0000226microtubule cytoskeleton organization
BPIMPGO:0006468protein phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0032092positive regulation of protein binding
BPIDAGO:0035331negative regulation of hippo signaling
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0036289peptidyl-serine autophosphorylation

Gene expression in normal tissue: MARK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MARK3


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B4
iGMDRD394BX-7953
iGMDRD193Fqi12
iGMDRD446LY 21832404
iGMDRD560MK-22063
iGMDRD424Tamatinib2
iGMDRD420Leucascandrolide A2
iGMDRD64Parbendazole2
iGMDRD369TGX-1152
iGMDRD329Merck601
iGMDRD100Zebularine2
iGMDRD399Selumetinib3
iGMDRD77Itraconazole2
iGMDRD294Batimastat2
iGMDRD187BRD98761
iGMDRD434BMS-5369241
iGMDRD255SB2250023
iGMDRD513BML-2591
iGMDRD121GMX17782
iGMDRD158NSC1415403

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MARK3

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