ITIH6
Summary: The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inter-alpha-trypsin inhibitor heavy chain family member 6 | Ensembl:ENSG00000102313 | HGNC:HGNC:28907 | PA134930661 | Xp11.22 |
GO terms in ITIH6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005576 | extracellular region |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IEA | GO:0030212 | hyaluronan metabolic process |
| MF | IEA | GO:0004867 | serine-type endopeptidase inhibitor activity |
Gene expression in normal tissue: ITIH6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITIH6
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD484 | Pluripotin | 5 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD71 | Sparfosic acid | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD399 | Selumetinib | 7 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 5 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD705 | Nakiterpiosin | 7 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD481 | Dactolisib | 4 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD886 | Compound 1541A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITIH6
CLASSFICATION
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