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ITIH6

Summary: The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameinter-alpha-trypsin inhibitor heavy chain family member 6 OMIM ID Ensembl IDEnsembl:ENSG00000102313 HGNC IDHGNC:HGNC:28907 PHARMGKB IDPA134930661 Map LocationXp11.22

Gene Categories:

PROTEASE INHIBITOR PROTEASE DRUGGABLE GENOME

GO terms in ITIH6

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0005576	extracellular region
BP	IEA	GO:0010951	negative regulation of endopeptidase activity
BP	IEA	GO:0030212	hyaluronan metabolic process
MF	IEA	GO:0004867	serine-type endopeptidase inhibitor activity

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Gene expression in normal tissue: ITIH6

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITIH6

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD126	Tipifarnib	1
iGMDRD420	Leucascandrolide A	2
iGMDRD670	ML 210	2
iGMDRD779	PRL-3 Inhibitor I	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITIH6

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.