ITIH6


Summary: The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inter-alpha-trypsin inhibitor heavy chain family member 6Ensembl:ENSG00000102313HGNC:HGNC:28907PA134930661Xp11.22

GO terms in ITIH6


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005576extracellular region
BPIEAGO:0010951negative regulation of endopeptidase activity
BPIEAGO:0030212hyaluronan metabolic process
MFIEAGO:0004867serine-type endopeptidase inhibitor activity

Gene expression in normal tissue: ITIH6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITIH6


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib1
iGMDRD420Leucascandrolide A2
iGMDRD670ML 2102
iGMDRD779PRL-3 Inhibitor I3
iGMDRD427ABT7375
iGMDRD781Sirolimus1
iGMDRD484Pluripotin5
iGMDRD494Neopeltolide3
iGMDRD483SCH-5290743
iGMDRD71Sparfosic acid2
iGMDRD201SKI II2
iGMDRD107Valdecoxib3
iGMDRD280CYTOCHALASIN B5
iGMDRD297Austocystin D2
iGMDRD375GW-4058332
iGMDRD138PX 122
iGMDRD260FQI-22
iGMDRD171Pemetrexed2
iGMDRD441TW 371
iGMDRD226ML0062
iGMDRD318PAC-11
iGMDRD885Compound 1105
iGMDRD399Selumetinib7
iGMDRD562Navitoclax3
iGMDRD780PP-303
iGMDRD577BIX012942
iGMDRD506Fedratinib1
iGMDRD60Quinoclamine4
iGMDRD524ISX-95
iGMDRD584VER 1550082
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD523Cyanoquinoline, 115
iGMDRD341Triacsin c4
iGMDRD57Chloropentafluorobenzene2
iGMDRD211(1S,3R)-RSL32
iGMDRD271Brefeldin A3
iGMDRD705Nakiterpiosin7
iGMDRD105Triptolide2
iGMDRD213SMR0000686502
iGMDRD481Dactolisib4
iGMDRD872BRD71371
iGMDRD871BRD63681
iGMDRD414MST-3123
iGMDRD329Merck606
iGMDRD662JQ-12
iGMDRD300Tozasertib4
iGMDRD886Compound 1541A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITIH6

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