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iGMDRD523

Canonical SMILES: C1=CC(=C(C=C1NC2=C(C=NC3=C(C=C(C=C32)NCC4=CN=CN4)Cl)C#N)Cl)F

InChI: InChI=1S/C20H13Cl2FN6/c21-16-4-12(1-2-18(16)23)29-19-11(6-24)7-27-20-15(19)3-13(5-17(20)22)26-9-14-8-25-10-28-14/h1-5,7-8,10,26H,9H2,(H,25,28)(H,27,29)

InChI Key: ONXROKMQGCSOMG-UHFFFAOYSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
Cyanoquinoline 11	17759600	Alone	Small Molecule

Drug Targets:

MAP3K8

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	2
27102	EIF2AK1	1
9833	MELK	3
5296	PIK3R2	1
5261	PHKG2	1
21	ABCA3	3
29101	SSU72	6
4627	MYH9	1
1588	CYP19A1	3
347365	ITIH6	5
23552	CDK20	1
8289	ARID1A	2
80070	ADAMTS20	6
3939	LDHA	3
7764	ZNF217	3
353345	GPR141	3
6657	SOX2	3
4771	NF2	3
10863	ADAM28	2
4170	MCL1	1
22853	LMTK2	3
55781	RIOK2	3
7253	TSHR	6
2249	FGF4	3
1387	CREBBP	4
2043	EPHA4	3
5788	PTPRC	2
2313	FLI1	3
11200	CHEK2	3
31	ACACA	4
10178	TENM1	2
9411	ARHGAP29	1
5074	PAWR	3
10438	C1D	2
9024	BRSK2	3
51512	GTSE1	6
139378	ADGRG4	3
89910	UBE3B	3
974	CD79B	3
4001	LMNB1	3
4610	MYCL	5
816	CAMK2B	3
342977	NANOS3	1
256646	NUTM1	3
3927	LASP1	3
4005	LMO2	2
3645	INSRR	3
9175	MAP3K13	1
2260	FGFR1	3
116986	AGAP2	2
10217	CTDSPL	2
2736	GLI2	3
2908	NR3C1	1
6928	HNF1B	5
7088	TLE1	2
7424	VEGFC	3
22858	ICK	2
57476	GRAMD1B	2
440730	TRIM67	3
158056	MAMDC4	3
2068	ERCC2	2
8091	HMGA2	2
9472	AKAP6	2
472	ATM	4
139285	AMER1	4
9096	TBX18	3
9564	BCAR1	1
1123	CHN1	3
5289	PIK3C3	2
898	CCNE1	3
5129	CDK18	3
27436	EML4	2
7157	TP53	1
2099	ESR1	3
6092	ROBO2	6
4855	NOTCH4	5
2322	FLT3	3
960	CD44	2
5910	RAP1GDS1	6
10114	HIPK3	2
114788	CSMD3	2
225689	MAPK15	5
1019	CDK4	1
65243	ZFP69B	5
5604	MAP2K1	3
1555	CYP2B6	2
23043	TNIK	3
57105	CYSLTR2	3
65125	WNK1	3
2081	ERN1	3
4026	LPP	1
10499	NCOA2	1
23469	PHF3	3
23373	CRTC1	3
546	ATRX	2
5297	PI4KA	1
10535	RNASEH2A	2
602	BCL3	3
5290	PIK3CA	4
1000	CDH2	10
26524	LATS2	2
2318	FLNC	5
10565	ARFGEF1	2
7075	TIE1	3
744	MPPED2	1
1956	EGFR	7
3065	HDAC1	3
283629	TSSK4	3
51265	CDKL3	4
79759	ZNF668	3
833	CARS	3
204851	HIPK1	3
3635	INPP5D	2
3949	LDLR	3
56924	PAK6	3
10186	LHFPL6	2
84879	MFSD2A	2
23532	PRAME	5
5598	MAPK7	3
120892	LRRK2	3
7027	TFDP1	3
7301	TYRO3	3
8626	TP63	11
9843	HEPH	1
23742	NPAP1	2
23049	SMG1	2
5595	MAPK3	4
7155	TOP2B	2
80124	VCPIP1	3
140803	TRPM6	3
85409	NKD2	3
3678	ITGA5	4
1676	DFFA	3
1445	CSK	3
8522	GAS7	2
7454	WAS	5
2277	VEGFD	4
1281	COL3A1	2
9659	PDE4DIP	1
9201	DCLK1	3
283455	KSR2	2
4628	MYH10	3
5587	PRKD1	4
79837	PIP4K2C	4
3984	LIMK1	2
51562	MBIP	2
5915	RARB	3
4261	CIITA	3
4330	MN1	1
23512	SUZ12	3
5324	PLAG1	3
255239	ANKK1	3
2011	MARK2	2
4915	NTRK2	2
3092	HIP1	2
4763	NF1	4
5260	PHKG1	10
5288	PIK3C2G	5
30811	HUNK	7
81788	NUAK2	3
1608	DGKG	3
27255	CNTN6	3
83732	RIOK1	2
29110	TBK1	4
2444	FRK	3
5602	MAPK10	1
2892	GRIA3	5

Gene in drug-gene network: Network Plot

Models in Cyanoquinoline 11

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.