PI4KA
Summary: This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol 4-kinase alpha | MIM:600286 | Ensembl:ENSG00000241973 | HGNC:HGNC:8983 | PA162399305 | 22q11.21 |
GO terms in PI4KA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004430 | 1-phosphatidylinositol 4-kinase activity |
| MF | ISS | GO:0004430 | 1-phosphatidylinositol 4-kinase activity |
| MF | TAS | GO:0004430 | 1-phosphatidylinositol 4-kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IBA | GO:0052742 | phosphatidylinositol kinase activity |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IDA | GO:0016310 | phosphorylation |
| BP | IMP | GO:0039694 | viral RNA genome replication |
| BP | IMP | GO:0044803 | multi-organism membrane organization |
| BP | IMP | GO:0046786 | viral replication complex formation and maintenance |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | ISS | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IBA | GO:0048015 | phosphatidylinositol-mediated signaling |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | IMP | GO:0019034 | viral replication complex |
| CC | ISS | GO:0030660 | Golgi-associated vesicle membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: PI4KA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PI4KA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483248 | Synthesis of PIPs at the ER membrane |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane |
| reactome | R-HSA-556833 | Metabolism of lipids |
| netpath | Pathway_TCR | TCR |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| wikipathways | WP2858 | Ectoderm Differentiation |
| smpdb | SMP00011 | Inositol Metabolism |
| smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
| smpdb | SMP00582 | Joubert syndrome |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD246 | NPC26 | 3 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD154 | NSC23766 | 5 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD598 | QS-11 | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD100 | Zebularine | 7 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD888 | Compound 44 | 7 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD599 | Salermide | 7 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PI4KA
CLASSFICATION
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