PI4KA
Summary: This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2018].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600286 Ensembl IDEnsembl:ENSG00000241973 HGNC IDHGNC:HGNC:8983 PHARMGKB IDPA162399305 Map Location22q11.21 | |||||
GO terms in PI4KA
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004430 | 1-phosphatidylinositol 4-kinase activity |
| MF | ISS | GO:0004430 | 1-phosphatidylinositol 4-kinase activity |
| MF | TAS | GO:0004430 | 1-phosphatidylinositol 4-kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
Gene expression in normal tissue: PI4KA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PI4KA
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483248 | Synthesis of PIPs at the ER membrane |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PI4KA
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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